study year pubmed_link first_author last_author animal_species animal_strain animal_model_name animal_model_citation prnp_genotype prp_expression_level prion_strain avg_age_at_inoculation_days inoculum_titer inoculum_volume_ul infection_route treatment_route vehicle control_compound compound dose_description dose_number_deprecated peak_dose_mgkgday equiv_peak_dose_mg_70kg_human treatment_started_dpi treatment_stopped_dpi endpoint treatment_days_to_endpoint treatment_sd treatment_sem treatment_n control_days_to_endpoint control_sd control_n delay reported_p eyeballed comments Cortes 2012 2012 Cortes Mastrianni mice - Tg(PrP-A116V) Yang 2009 http://www.ncbi.nlm.nih.gov/pubmed/19675240/ A117V/129V 5 GSS oral rapamycin 10mg/kg 3x/week 4.3 24.3 42 death onset 149.0 3.7 24 134.0 2.6 20 0.11 0.05 treatment started figures refer to age of mice Cortes 2012 2012 Cortes Mastrianni mice - Tg(PrP-A116V) Yang 2009 http://www.ncbi.nlm.nih.gov/pubmed/19675240/ A117V/129V 5 GSS oral rapamycin 20mg/kg 3x/week 8.6 48.6 42 death onset 159.0 4.2 23 134.0 2.6 20 0.19 0.0001 treatment started figures refer to age of mice Cortes 2012 2012 Cortes Mastrianni mice - Tg(PrP-A116V) Yang 2009 http://www.ncbi.nlm.nih.gov/pubmed/19675240/ A117V/129V 5 GSS oral rapamycin 10mg/kg 3x/week 4.3 24.3 42 death survival 175 3.8 19 173.0 3.7 20 0.01 1 treatment started figures refer to age of mice Cortes 2012 2012 Cortes Mastrianni mice - Tg(PrP-A116V) Yang 2009 http://www.ncbi.nlm.nih.gov/pubmed/19675240/ A117V/129V 5 GSS oral rapamycin 20mg/kg 3x/week 8.6 48.6 42 death survival 189 3.8 17 173.0 3.7 20 0.09 0.018 treatment started figures refer to age of mice Pocchiari 1987 1987 Pocchiari Masullo hamsters - 1 263K weaning 0.1 i.c. i.p. .9% NaCl .9% NaCl amphotericin b 1mg/kg 6x/week (increased from starting dose of 0.1mg/kg) 0.9 8.1 0 50 clinical signs 82.7 5.1 7 54.6 4.7 62 0.51 0.0001 Pocchiari 1987 1987 Pocchiari Masullo hamsters - 1 263K weaning 0.1 i.c. i.p. .9% NaCl .9% NaCl amphotericin b 1mg/kg 6x/week (increased from starting dose of 0.1mg/kg) 0.9 8.1 0 75 clinical signs 95.9 3.5 8 54.6 4.7 62 0.76 0.0001 Pocchiari 1987 1987 Pocchiari Masullo hamsters - 1 263K weaning 0.1 i.c. i.p. .9% NaCl .9% NaCl amphotericin b 1mg/kg 6x/week (increased from starting dose of 0.1mg/kg) 0.9 8.1 0 100 clinical signs 101.6 2.2 7 54.6 4.7 62 0.86 0.0001 Pocchiari 1987 1987 Pocchiari Masullo hamsters - 1 263K weaning 0.1 i.c. i.p. .9% NaCl .9% NaCl amphotericin b 1mg/kg 6x/week (increased from starting dose of 0.1mg/kg) 0.9 8.1 55 advanced clinical signs advanced clinical signs 14.1 2.5 10 14.3 3.7 7 -0.01 1 "treated from onset of clinical signs, which occurred at 54.6 +/- 4.7 dpi. tested delay from clinical onset (score 3) to 'advanced' clinical signs." Pocchiari 1987 1987 Pocchiari Masullo hamsters - 1 263K weaning 0.1 i.p. i.p. .9% NaCl .9% NaCl amphotericin b 1mg/kg 6x/week (increased from starting dose of 0.1mg/kg) 0.9 8.1 0 50 clinical signs 162.8 31.3 5 107.2 6.9 5 0.52 Pocchiari 1989 1989 Pocchiari Ladogana hamsters - 263K 0.1 50 i.c. i.p. sodium deoxycholate in phosphate buffer sodium deoxycholate in phosphate buffer amphotericin b 1 mg/kg 6x/wk 0.9 8.1 -14 0 clinical signs 71.1 2.3 9 51.2 1.3 9 0.39 0.001 Pocchiari 1989 1989 Pocchiari Ladogana hamsters - 263K 0.1 50 i.c. i.p. sodium deoxycholate in phosphate buffer sodium deoxycholate in phosphate buffer amphotericin b 1 mg/kg 6x/wk 0.9 8.1 0 7 clinical signs 64.9 1.7 8 51.2 1.3 9 0.27 0.001 Pocchiari 1989 1989 Pocchiari Ladogana hamsters - 263K 0.1 50 i.c. i.p. sodium deoxycholate in phosphate buffer sodium deoxycholate in phosphate buffer amphotericin b 1 mg/kg 6x/wk 0.9 8.1 7 14 clinical signs 56.5 1.0 8 51.2 1.3 9 0.10 0.01 Pocchiari 1989 1989 Pocchiari Ladogana hamsters - 263K 0.1 50 i.c. i.p. sodium deoxycholate in phosphate buffer sodium deoxycholate in phosphate buffer amphotericin b 1 mg/kg 6x/wk 0.9 8.1 21 28 clinical signs 57.1 1.5 8 51.2 1.3 9 0.12 0.01 Pocchiari 1989 1989 Pocchiari Ladogana hamsters - 263K 0.1 50 i.c. i.p. sodium deoxycholate in phosphate buffer sodium deoxycholate in phosphate buffer amphotericin b 1 mg/kg 6x/wk 0.9 8.1 28 35 clinical signs 52.8 0.4 8 51.2 1.3 9 0.03 1 Pocchiari 1989 1989 Pocchiari Ladogana hamsters - 263K 0.1 50 i.c. i.p. sodium deoxycholate in phosphate buffer sodium deoxycholate in phosphate buffer amphotericin b 0.1 mg/kg 6x/wk 0.1 0.8 0 50 clinical signs 70.4 2.0 8 56.7 0.5 14 0.24 0.001 Pocchiari 1989 1989 Pocchiari Ladogana hamsters - 263K 0.1 50 i.c. i.p. sodium deoxycholate in phosphate buffer sodium deoxycholate in phosphate buffer amphotericin b 1 mg/kg 6x/wk 0.9 8.1 0 50 clinical signs 78.3 2.2 7 56.7 0.5 14 0.38 0.001 Pocchiari 1989 1989 Pocchiari Ladogana hamsters - 263K 0.1 50 i.c. i.p. sodium deoxycholate in phosphate buffer sodium deoxycholate in phosphate buffer amphotericin b 5 mg/kg 6x/wk 4.3 40.5 0 50 clinical signs 89.1 1.1 8 56.7 0.5 14 0.57 0.001 Pocchiari 1989 1989 Pocchiari Ladogana hamsters - 263K 0.1 50 i.c. i.p. sodium deoxycholate in phosphate buffer sodium deoxycholate in phosphate buffer amphotericin b 10 mg/kg 6x/wk 8.6 81.1 0 10 clinical signs 77.8 1.4 4 56.7 0.5 14 0.37 0.001 half (4/8) the mice died of the AmB dose Pocchiari 1989 1989 Pocchiari Ladogana hamsters - 263K 0.1 50 i.p. i.p. sodium deoxycholate in phosphate buffer sodium deoxycholate in phosphate buffer amphotericin b 1 mg/kg 6x/wk 0.9 8.1 40 clinical signs clinical signs 122.3 8.1 7 104.6 2.3 0.17 0.05 Pocchiari 1989 1989 Pocchiari Ladogana hamsters - 263K 0.1 50 i.p. i.p. sodium deoxycholate in phosphate buffer sodium deoxycholate in phosphate buffer amphotericin b 1 mg/kg 6x/wk 0.9 8.1 50 clinical signs clinical signs 111.2 7.3 7 104.6 2.3 0.06 1 Pocchiari 1989 1989 Pocchiari Ladogana hamsters - 263K 0.1 50 i.p. i.p. sodium deoxycholate in phosphate buffer sodium deoxycholate in phosphate buffer amphotericin b 1 mg/kg 6x/wk 0.9 8.1 60 clinical signs clinical signs 100.9 4.7 7 104.6 2.3 -0.04 1 Pocchiari 1989 1989 Pocchiari Ladogana hamsters - 263K 0.1 50 i.c. i.p. diluted saline diluted saline mepartricin .025 mg/kg 6x/wk 0.021 0.2 0 50 clinical signs 65.4 1.9 9 60.7 0.8 18 0.08 1 Pocchiari 1989 1989 Pocchiari Ladogana hamsters - 263K 0.1 50 i.c. i.p. diluted saline diluted saline mepartricin .25 mg/kg 6x/wk 0.2 2.0 0 50 clinical signs 61.7 2.2 9 60.7 0.8 18 0.02 1 Pocchiari 1989 1989 Pocchiari Ladogana hamsters - 263K 0.1 50 i.c. i.p. diluted saline diluted saline mepartricin 1 mg/kg 6x/wk 0.9 8.1 0 50 clinical signs 59.0 0.1 8 60.7 0.8 18 -0.03 1 Pocchiari 1989 1989 Pocchiari Ladogana hamsters - 263K 0.1 50 i.p. i.p. diluted saline diluted saline mepartricin .25 mg/kg 6x/wk 0.2 2.0 0 50 clinical signs 100.8 10.7 6 91.2 2.4 18 0.11 1 Pocchiari 1989 1989 Pocchiari Ladogana hamsters - 263K 0.1 50 i.p. i.p. diluted saline diluted saline mepartricin 1 mg/kg 6x/wk 0.9 8.1 0 50 clinical signs 112.8 8.3 5 91.2 2.4 18 0.24 0.005 Xi 1992 1992 Xi Pocchiari hamsters - 263K weaning 0.1 50 i.c. i.p. sodium deoxycholate in phosphate buffer amphotericin b 1 mg/kg 6x/wk 0.9 8.1 1 clinical signs clinical signs 98.6 2.7 9 56.6 3.7 17 0.74 0.001 Xi 1992 1992 Xi Pocchiari hamsters - 139H weaning 0.1 50 i.c. i.p. sodium deoxycholate in phosphate buffer amphotericin b 1 mg/kg 6x/wk 0.9 8.1 0 130 clinical signs 138.2 1.0 13 138.1 3.3 20 0.00 1 Xi 1992 1992 Xi Pocchiari mice Swiss 139A 0.1 30 i.c. i.p. sodium deoxycholate in phosphate buffer amphotericin b 3 mg/kg 6x/wk 2.6 14.6 0 90 clinical signs 131.9 7.3 12 131.4 3.9 17 0.00 1 McKenzie 1994 1994 McKenzie Aiken hamsters Syrian 263K 0.01 50 i.c. i.p. amphotericin b 1 mg/kg 6x/wk 0.9 8.1 1 ? clinical signs 87.5 4.8 25 61.7 2.6 19 0.42 0.0005 McKenzie 1994 1994 McKenzie Aiken hamsters Syrian 263K 0.01 50 i.c. i.p. amphotericin b 1 mg/kg 6x/wk 0.9 8.1 1 ? survival 107.0 3.1 16 83.7 2.8 12 0.28 0.0005 Demaimay 1994 1994 Demaimay Dormont hamsters Syrian 263K 0.01 50 i.c. i.p. 5% w/v glucose solution see comments amphotericin b 2.5 mg/kg/day 2.1 20.3 0 7 survival 98.7 0.7 3 84.0 5 0.18 0.03 averaged NMG (88 dpi) and untreated controls (81.3 dpi) which were not significantly different from each other Demaimay 1994 1994 Demaimay Dormont hamsters Syrian 263K 0.01 50 i.c. i.p. NMG in 5% wt/vol glucose solution see comments MS-8209 2.5 mg/kg/day 2.1 20.3 0 7 survival 100.7 0.3 3 84.0 5 0.20 0.03 averaged NMG and untreated controls which were not significantly different from each other Demaimay 1994 1994 Demaimay Dormont mice - C506M3 0.01 20 i.c. i.p. 5% w/v glucose solution untreated amphotericin b 2.5 mg/kg/day 2.1 12.2 0 death survival 222.7 7.1 6 170.7 2.3 3 0.30 0.03 "control average (n=3) was duplicated in 24 other mice, ""data not shown""" Demaimay 1994 1994 Demaimay Dormont mice - C506M3 0.01 20 i.c. i.p. NMG in 5% wt/vol glucose solution untreated MS-8209 2.5 mg/kg/day 2.1 12.2 0 death survival 214.8 16.6 6 170.7 2.3 3 0.26 0.03 "control average (n=3) was duplicated in 24 other mice, ""data not shown""" Demaimay 1994 1994 Demaimay Dormont mice - C506M3 0.01 80 i.c. i.p. NMG in 5% wt/vol glucose solution see comments MS-8209 .25 mg/kg/day 0.2 1.2 -7 40 survival 330.0 3.9 6 329.6 6.7 6 0.00 1 averaged NMG (88 dpi) and untreated controls (81.3 dpi) which were not significantly different from each other Demaimay 1994 1994 Demaimay Dormont mice - C506M3 0.01 80 i.c. i.p. NMG in 5% wt/vol glucose solution see comments MS-8209 2.5 mg/kg/day 2.1 12.2 -7 40 survival 349.3 9.5 5 329.6 6.7 6 0.06 0.04 averaged NMG and untreated controls which were not significantly different from each other Demaimay 1994 1994 Demaimay Dormont mice - C506M3 0.01 80 i.c. i.p. MS-8209 25 mg/kg/day 21.4 121.6 -7 40 survival 357.1 7.5 12 332.7 6.7 6 0.07 0.001 Adjou 1995 1995 Adjou Dormont hamsters Syrian 263K 0.01 50 i.c. i.p. amphotericin b 2.5 mg/kg 6x/wk 2.5 2.1 20.3 0 death survival 144.0 1.7 86.6 1.3 0.66 0.005 Adjou 1995 1995 Adjou Dormont hamsters Syrian 263K 0.01 50 i.c. i.p. MS-8209 2.5 mg/kg 6x/wk 2.5 2.1 20.3 0 death survival 151.5 0.7 86.6 1.3 0.75 0.005 Adjou 1995 1995 Adjou Dormont hamsters Syrian 263K 0.01 50 i.c. i.p. MS-8209 10 mg/kg 6x/wk 10 8.6 81.1 0 death survival 171.0 1.0 86.6 1.3 0.97 0.005 Adjou 1995 1995 Adjou Dormont hamsters Syrian 263K 0.01 50 i.c. i.p. MS-8209 25 mg/kg 6x/wk 25 21.4 202.7 0 death survival 171.1 1.2 86.6 1.3 0.98 0.005 Adjou 1995 1995 Adjou Dormont hamsters Syrian 263K 0.01 50 i.c. i.p. amphotericin b 1 mg/kg 6x/wk 1 0.9 8.1 -14 0 survival 106.0 6 87.0 12 0.22 1 numbers estimated from visual in Fig1A Adjou 1995 1995 Adjou Dormont hamsters Syrian 263K 0.01 50 i.c. i.p. amphotericin b 2.5 mg/kg 6x/wk 2.5 2.1 20.3 0 6 survival 100.0 6 87.0 12 0.15 1 numbers estimated from visual in Fig1A Adjou 1995 1995 Adjou Dormont hamsters Syrian 263K 0.01 50 i.c. i.p. MS-8209 2.5 mg/kg 6x/wk 2.5 2.1 20.3 0 6 survival 102.0 6 87.0 12 0.17 1 numbers estimated from visual in Fig1A Adjou 1995 1995 Adjou Dormont hamsters Syrian 263K 0.01 50 i.c. i.p. MS-8209 2.5 mg/kg 6x/wk 2.5 2.1 20.3 -14 0 survival 104.0 6 87.0 12 0.20 1 numbers estimated from visual in Fig1A Adjou 1995 1995 Adjou Dormont hamsters Syrian 263K 0.01 50 i.c. i.p. MS-8209 25 mg/kg 6x/wk 25 21.4 202.7 0 6 survival 120.0 6 87.0 12 0.38 1 numbers estimated from visual in Fig1A Adjou 1995 1995 Adjou Dormont hamsters Syrian 263K 0.01 50 i.c. i.p. MS-8209 25 mg/kg 6x/wk 25 21.4 202.7 -14 0 survival 118.0 6 87.0 12 0.36 1 numbers estimated from visual in Fig1A Adjou 1995 1995 Adjou Dormont hamsters Syrian 263K 0.01 50 i.c. i.p. MS-8209 25 mg/kg 6x/wk 25 21.4 202.7 -7 7 survival 122.0 6 87.0 12 0.40 1 numbers estimated from visual in Fig1A Adjou 1995 1995 Adjou Dormont hamsters Syrian 263K 0.01 50 i.c. i.p. amphotericin b 50 mg/kg one-time dose 50 42.9 405.4 0 0 survival 110.0 4 87.0 12 0.26 1 numbers estimated from visual in Fig1A; some mice died of toxicity Adjou 1995 1995 Adjou Dormont hamsters Syrian 263K 0.01 50 i.c. i.p. MS-8209 50 mg/kg one-time dose 50 42.9 405.4 0 0 survival 108.0 4 87.0 12 0.24 1 numbers estimated from visual in Fig1A; some mice died of toxicity Adjou 1995 1995 Adjou Dormont hamsters Syrian 263K 0.01 50 i.c. i.p. MS-8209 100 mg/kg one-time dose 100 85.7 810.8 0 0 survival 111.0 4 87.0 12 0.28 1 numbers estimated from visual in Fig1A; some mice died of toxicity Demaimay 1997 1997 Demaimay Dormont hamsters Syrian C506M3 0.01 20 i.c. i.p. amphotericin b 2.5 mg/kg 6x/wk 2.5 2.1 20.3 90 120 survival 169.7 3.1 5 159.8 2.5 4 0.06 1 0 Demaimay 1997 1997 Demaimay Dormont hamsters Syrian C506M3 0.01 20 i.c. i.p. MS-8209 2.5 mg/kg 6x/wk 2.5 2.1 20.3 90 120 survival 176.0 4.4 5 159.8 2.5 4 0.10 0.01 0 Demaimay 1997 1997 Demaimay Dormont hamsters Syrian C506M3 0.01 20 i.c. i.p. amphotericin b 2.5 mg/kg 6x/wk 2.5 2.1 20.3 90 120 survival 179.9 6.3 8 169.4 4.7 11 0.06 0.01 0 Demaimay 1997 1997 Demaimay Dormont hamsters Syrian C506M3 0.01 20 i.c. i.p. MS-8209 2.5 mg/kg 6x/wk 2.5 2.1 20.3 90 120 survival 178.7 4.3 7 169.4 4.7 11 0.05 0.01 0 Demaimay 1997 1997 Demaimay Dormont hamsters Syrian C506M3 0.01 20 i.c. i.p. MS-8209 25 mg/kg 6x/wk 25 21.4 202.7 90 120 survival 190.6 9.1 7 169.4 4.7 11 0.13 0.01 0 Demaimay 1997 1997 Demaimay Dormont hamsters Syrian C506M3 0.01 20 i.c. i.p. amphotericin b 1 mg/kg 6x/wk 1 0.9 8.1 80 death survival 187.0 1.4 8 158.0 3.1 6 0.18 0.01 0 Demaimay 1997 1997 Demaimay Dormont hamsters Syrian C506M3 0.01 20 i.c. i.p. amphotericin b 2.5 mg/kg 6x/wk 2.5 2.1 20.3 80 death survival 196.0 2.3 8 158.0 3.1 6 0.24 0.01 0 Demaimay 1997 1997 Demaimay Dormont hamsters Syrian C506M3 0.01 20 i.c. i.p. MS-8209 1 mg/kg 6x/wk 1 0.9 8.1 80 death survival 187.0 2.4 8 158.0 3.1 6 0.18 0.01 0 Demaimay 1997 1997 Demaimay Dormont hamsters Syrian C506M3 0.01 20 i.c. i.p. MS-8209 2.5 mg/kg 6x/wk 2.5 2.1 20.3 80 death survival 198.0 1.3 8 158.0 3.1 6 0.25 0.01 0 Demaimay 1997 1997 Demaimay Dormont hamsters Syrian C506M3 0.01 20 i.c. i.p. MS-8209 25 mg/kg 6x/wk 25 21.4 202.7 80 death survival 221.0 4.1 8 158.0 3.1 6 0.40 0.01 0 Demaimay 1997 1997 Demaimay Dormont hamsters Syrian C506M3 0.01 20 i.c. i.p. amphotericin b 1 mg/kg 6x/wk 1 0.9 8.1 110 death survival 182.0 1.4 8 160.0 2.5 6 0.14 0.01 0 Demaimay 1997 1997 Demaimay Dormont hamsters Syrian C506M3 0.01 20 i.c. i.p. amphotericin b 2.5 mg/kg 6x/wk 2.5 2.1 20.3 110 death survival 182.0 1.6 8 160.0 2.5 6 0.14 0.01 0 Demaimay 1997 1997 Demaimay Dormont hamsters Syrian C506M3 0.01 20 i.c. i.p. MS-8209 1 mg/kg 6x/wk 1 0.9 8.1 110 death survival 173.0 3.1 8 160.0 2.5 6 0.08 0.01 0 Demaimay 1997 1997 Demaimay Dormont hamsters Syrian C506M3 0.01 20 i.c. i.p. MS-8209 2.5 mg/kg 6x/wk 2.5 2.1 20.3 110 death survival 180.0 1.3 8 160.0 2.5 6 0.13 0.01 0 Demaimay 1997 1997 Demaimay Dormont hamsters Syrian C506M3 0.01 20 i.c. i.p. MS-8209 25 mg/kg 6x/wk 25 21.4 202.7 110 death survival 190.0 2.2 8 160.0 2.5 6 0.19 0.01 0 Demaimay 1997 1997 Demaimay Dormont hamsters Syrian C506M3 0.01 20 i.c. i.p. amphotericin b 1 mg/kg 6x/wk 1 0.9 8.1 140 death survival 164.0 2.2 12 157.0 1.2 6 0.04 0.05 0 some mice died of toxicity Demaimay 1997 1997 Demaimay Dormont hamsters Syrian C506M3 0.01 20 i.c. i.p. amphotericin b 2.5 mg/kg 6x/wk 2.5 2.1 20.3 140 death survival 167.0 2.5 11 157.0 1.2 6 0.06 0.05 0 some mice died of toxicity Demaimay 1997 1997 Demaimay Dormont hamsters Syrian C506M3 0.01 20 i.c. i.p. MS-8209 1 mg/kg 6x/wk 1 0.9 8.1 140 death survival 164.0 2.1 10 157.0 1.2 6 0.04 1 0 Demaimay 1997 1997 Demaimay Dormont hamsters Syrian C506M3 0.01 20 i.c. i.p. MS-8209 2.5 mg/kg 6x/wk 2.5 2.1 20.3 140 death survival 165.0 2.2 11 157.0 1.2 6 0.05 0.05 0 some mice died of toxicity Demaimay 1997 1997 Demaimay Dormont hamsters Syrian C506M3 0.01 20 i.c. i.p. MS-8209 25 mg/kg 6x/wk 25 21.4 202.7 140 death survival 172.0 3.4 12 157.0 1.2 6 0.10 0.05 0 some mice died of toxicity Adjou 1999 1999 Adjou Dormont hamsters Syrian 263K 0.01 50 i.c. i.p. amphotericin b 1 mg/kg 6x/wk 1 0.9 8.1 0 death survival 0.46 0 Adjou 1999 1999 Adjou Dormont hamsters Syrian 263K 0.01 50 i.c. i.p. amphotericin b 2.5 mg/kg 6x/wk 2.5 2.1 20.3 0 death survival 0.66 0 Adjou 1999 1999 Adjou Dormont hamsters Syrian 263K 0.01 50 i.c. i.p. MS-8209 2.5 mg/kg 6x/wk 2.5 2.1 20.3 0 death survival 0.75 0 Adjou 1999 1999 Adjou Dormont hamsters Syrian 263K 0.01 50 i.c. i.p. MS-8209 10 mg/kg 6x/wk 10 8.6 81.1 0 death survival 1.00 0 Adjou 1999 1999 Adjou Dormont hamsters Syrian 263K 0.01 50 i.c. i.p. MS-8209 25 mg/kg 6x/wk 25 21.4 202.7 0 death survival 1.00 0 Adjou 2000 2000 Adjou Dormont hamsters Syrian 263K 0.01 50 i.c. i.p. amphotericin b 2.5 mg/kg 6x/wk 2.5 2.1 20.3 30 death survival 99.0 1.4 7 80.0 1.2 5 0.24 0.01 0 Adjou 2000 2000 Adjou Dormont hamsters Syrian 263K 0.01 50 i.c. i.p. MS-8209 10 mg/kg 6x/wk 10 8.6 81.1 30 death survival 116.0 0.9 6 80.0 1.2 5 0.45 0.01 0 Adjou 2000 2000 Adjou Dormont hamsters Syrian 263K 0.01 50 i.c. i.p. MS-8209 25 mg/kg 6x/wk 25 21.4 202.7 30 death survival 123.0 1.7 6 80.0 1.2 5 0.54 0.01 0 Adjou 1996 1996 Adjou Dormont mice C57BL/6 BSE (mouse-passaged) 0.01 20 i.c. i.p. amphotericin b 2.5 mg/kg 6x/wk 2.5 2.1 12.2 0 56 survival 171.0 0.5 10 165.0 1.4 10 0.04 0.05 0 Adjou 1996 1996 Adjou Dormont mice C57BL/6 BSE (mouse-passaged) 0.01 20 i.c. i.p. MS-8209 2.5 mg/kg 6x/wk 2.5 2.1 12.2 0 56 survival 167.0 1.3 10 165.0 1.4 10 0.01 1 0 Adjou 1996 1996 Adjou Dormont mice C57BL/6 BSE (mouse-passaged) 0.01 20 i.c. i.p. MS-8209 10 mg/kg 6x/wk 10 8.6 48.6 0 56 survival 174.0 1.5 10 165.0 1.4 10 0.05 0.05 0 Adjou 1996 1996 Adjou Dormont mice C57BL/6 BSE (mouse-passaged) 0.01 20 i.c. i.p. MS-8209 25 mg/kg 6x/wk 25 21.4 121.6 0 56 survival 170.0 1.5 10 165.0 1.4 10 0.03 0.05 0 Adjou 1996 1996 Adjou Dormont mice C57BL/6 C506M3 0.01 20 i.c. i.p. amphotericin b 2.5 mg/kg 6x/wk 2.5 2.1 12.2 0 56 survival 186.0 1.8 10 169.0 1.2 10 0.10 0.001 0 Adjou 1996 1996 Adjou Dormont mice C57BL/6 C506M3 0.01 20 i.c. i.p. MS-8209 2.5 mg/kg 6x/wk 2.5 2.1 12.2 0 56 survival 194.0 4.3 10 169.0 1.2 10 0.15 0.001 0 Wagner 2013 2013 Wagner Giese mice C57BL/6 wt 1 RML 49 0.01 30 i.c. oral dmso and peanut butter dmso and peanut butter anle138b 10 mg/day 5 400.0 2270.3 0 death survival 355.0 8 180.0 8 0.97 0.0001 0 Wagner 2013 2013 Wagner Giese mice C57BL/6 wt 1 RML 49 0.01 30 i.c. oral dmso and peanut butter dmso and peanut butter anle138b 5 mg/day 5 200.0 1135.1 80 death survival 242.0 8 168.0 8 0.44 0.0001 0 Wagner 2013 2013 Wagner Giese mice C57BL/6 wt 1 RML 49 0.01 30 i.c. oral dmso and peanut butter dmso and peanut butter anle138b 5 mg/day 5 200.0 1135.1 120 death survival 224.0 8 172.0 8 0.30 0.0001 0 Karapteyan & Sferrazza 2013 2013 "Karapetyan, Sferrazza" Lasmezas mice C57BL/6 wt 1 RML 56 0.01 20 i.c. i.p. 50% dmso 50% dmso tacrolimus 1.5 mg/kg/day 1.5 1.5 8.5 20 50 survival 149.0 7 149.0 2.0 5 0.00 1 1 "data not given, they merely state it's not significant" Karapteyan & Sferrazza 2013 2013 "Karapetyan, Sferrazza" Lasmezas mice C57BL/6 wt 1 RML 56 0.01 20 i.c. i.p. 50% dmso 50% dmso astemizole 3 mg/kg/day 3 3.0 17.0 20 50 survival 155.0 3.0 149.0 2.0 5 0.04 0.06 0 Mok 2006 2006 http://www.ncbi.nlm.nih.gov/pubmed/16890918 Mok Baier mice C57BL/6 wt 1 139A 0.001 20 i.c. oral food food simvastatin 100 mg/kg/day 100 100.0 567.6 100 death survival 194.0 6.0 10 178.0 7.0 10 0.09 0.0003 0 Mok 2006 2006 http://www.ncbi.nlm.nih.gov/pubmed/16890918 Mok Baier mice C57BL/6 wt 1 139A 0.0001 20 i.c. oral food food simvastatin 100 mg/kg/day 100 100.0 567.6 100 death survival 213.0 9.0 10 193.0 11.0 9 0.10 0.00003 0 Kempster 2007 2007 http://www.ncbi.nlm.nih.gov/pubmed/17496807 Kempster mice C57BL/6 wt 1 ME7 77 0.01 20 i.c. oral water water simvastatin 1 mg/kg/day 1 1.0 5.7 0 death survival 193.0 1.1 8 183.0 2.2 8 0.05 0.05 0 Kempster 2007 2007 http://www.ncbi.nlm.nih.gov/pubmed/17496807 Kempster mice C57BL/6 wt 1 ME7 77 0.01 20 i.c. oral water water simvastatin 1 mg/kg/day 1 1.0 5.7 0 death clinical signs 175.0 8 155.0 8 0.13 0 Kempster 2007 2007 http://www.ncbi.nlm.nih.gov/pubmed/17496807 Kempster mice C57BL/6 wt 1 ME7 77 0.01 20 i.c. oral water water simvastatin 1 mg/kg/day 1 1.0 5.7 123 death survival 187.0 5.0 8 183.0 2.2 8 0.02 0.3 0 Haviv 2008 2008 http://www.ncbi.nlm.nih.gov/pubmed/18541796 Haviv mice FVB/N wt 1 RML 0.01 30 i.c. oral water water simvastatin 2 escalating to 20 mg/kg/day 20 20.0 113.5 72 death survival 166.7 2.2 16 148.4 3.9 24 0.12 0.001 0 "expts a,c,d - average is from a,b,c,d" Haviv 2008 2008 http://www.ncbi.nlm.nih.gov/pubmed/18541796 Haviv mice FVB/N wt 1 RML 0.01 30 i.c. oral water water simvastatin 2 escalating to 20 mg/kg/day 20 20.0 113.5 41 death survival 166.7 2.2 4 148.4 3.9 24 0.12 0.001 0 "expt b - average is from a,b,c,d" Haviv 2008 2008 http://www.ncbi.nlm.nih.gov/pubmed/18541796 Haviv mice FVB/N wt 1 RML 0.01 30 i.c. oral water water simvastatin 2 mg/kg/day 2 2.0 11.4 72 death survival 161.7 3.5 4 148.4 3.9 24 0.09 0 Haviv 2008 2008 http://www.ncbi.nlm.nih.gov/pubmed/18541796 Haviv mice FVB/N wt 1 RML 0.01 30 i.p. oral water water simvastatin 2 mg/kg/day 2 2.0 11.4 0 death survival 243.0 11.2 10 226.4 34.3 10 0.07 0 Haviv 2008 2008 http://www.ncbi.nlm.nih.gov/pubmed/18541796 Haviv mice FVB/N wt 1 RML 0.01 30 i.p. oral water water simvastatin 20 mg/kg/day 20 20.0 113.5 0 death survival 239.1 2.5 9 226.4 34.3 10 0.06 0 Vetrugno 2009 2009 http://www.ncbi.nlm.nih.gov/pubmed/19282428 Vetrugno mice C57BL/6 wt 1 139A 0.01 i.c. oral water water pravastatin 200 mg/kg/day 200 200.0 1135.1 0 death survival 194.3 7.5 13 177.4 4.4 10 0.10 0.0001 0 Luigi 2008 2008 Luigi Salmona hamsters Syrian wt 1 263K 49 0.0001 100 i.m. i.m. saline none doxycycline 10 mg/kg one-time 0 0 survival 355.0 11 217.0 11 0.64 0.031 0 Luigi 2008 2008 Luigi Salmona hamsters Syrian wt 1 263K 49 0.0001 100 i.m. i.p. saline none doxycycline 10 mg/kg per two days 5.0 47.3 0 40 survival 312.0 11 250.0 11 0.25 0.032 0 Luigi 2008 2008 Luigi Salmona hamsters Syrian wt 1 263K 49 0.0001 100 i.m. i.p. saline none tetracycline 10 mg/kg per two days 5.0 47.3 0 40 survival 330.0 11 250.0 11 0.32 0.028 0 Luigi 2008 2008 Luigi Salmona hamsters Syrian wt 1 263K 49 0.0001 100 i.m. i.p. saline none minocycline 10 mg/kg per two days 5.0 47.3 0 40 survival 453.0 11 250.0 11 0.81 0.004 0 Luigi 2008 2008 Luigi Salmona hamsters Syrian wt 1 263K 49 0.0001 100 s.c. i.p. saline none doxycycline 10 mg/kg per two days 5.0 47.3 4 44 survival 823.0 11 611.0 11 0.35 0.004 0 Luigi 2008 2008 Luigi Salmona hamsters Syrian wt 1 263K 49 0.0001 20 i.c. i.c. liposomes none doxycycline 25 ug/20 uL one-time 30 30 survival 134.0 11 122.0 11 0.10 0.023 0 Luigi 2008 2008 Luigi Salmona hamsters Syrian wt 1 263K 49 0.0001 20 i.c. i.c. liposomes none doxycycline 25 ug/20 uL one-time 60 60 survival 140.5 11 130.0 11 0.08 0.037 0 Luigi 2008 2008 Luigi Salmona hamsters Syrian wt 1 263K 49 0.0001 20 i.c. i.c. liposomes none doxycycline 25 ug/20 uL one-time 60 60 survival 144.0 11 130.0 11 0.11 0.063 0 Riemer 2008 2008 Riemer Baier mice C57BL/6 wt 1 139A 35 0.001 30 i.c. oral food food ibuprofen 100 mg/kg/day 100.0 567.6 100 death survival 172.0 8.9 11 188.0 9.9 12 -0.09 0 Riemer 2008 2008 Riemer Baier mice C57BL/6 wt 1 139A 35 0.001 30 i.c. oral food food dapsone 16.75 mg/kg/day 16.8 95.1 100 death survival 189.0 11.4 9 188.0 9.9 12 0.01 1 0 Riemer 2008 2008 Riemer Baier mice C57BL/6 wt 1 139A 35 0.001 30 i.c. oral food food minocycline 200 mg/kg/day 200.0 1135.1 100 death survival 178.0 5.7 17 175.0 8.4 17 0.02 1 0 Riemer 2008 2008 Riemer Baier mice C57BL/6 wt 1 139A 35 0.001 30 i.c. oral food food curcumin 500 mg/kg/day 500.0 2837.8 100 death survival 174.0 9.0 17 174.0 8.6 16 0.00 1 0 Riemer 2008 2008 Riemer Baier mice C57BL/6 wt 1 139A 35 0.001 30 i.c. oral food food memantine 30 mg/kg/day 30.0 170.3 100 death survival 196.0 11.7 8 181.0 7.2 8 0.08 0.01 0 Riemer 2008 2008 Riemer Baier mice C57BL/6 wt 1 139A 35 0.0001 30 i.c. oral food food ibuprofen 100 mg/kg/day 100.0 567.6 100 death survival 191.0 17.3 12 196.0 10.1 13 -0.03 1 0 Riemer 2008 2008 Riemer Baier mice C57BL/6 wt 1 139A 35 0.0001 30 i.c. oral food food curcumin 50 mg/kg/day 50.0 283.8 100 death survival 208.0 8.4 12 196.0 10.1 13 0.06 0.01 0 Riemer 2008 2008 Riemer Baier mice C57BL/6 wt 1 139A 35 0.0001 30 i.c. oral food food curcumin 500 mg/kg/day 500.0 2837.8 100 death survival 192.0 9.7 14 192.0 9.2 16 0.00 1 0 Caughey 2003 2003 Caughey Baron hamsters wt 1 263K 0.01 50 i.c. oral food food curcumin .2% wt/wt -14 death survival 85.3 4.0 82.6 3.9 0.03 1 0 Caughey 2003 2003 Caughey Baron hamsters wt 1 263K 0.01 50 i.c. oral food food curcumin .2% wt/wt 0 death survival 84.1 4.3 82.6 3.9 0.02 1 0 Caughey 2003 2003 Caughey Baron hamsters wt 1 263K 0.01 50 i.c. oral food food curcumin .2% wt/wt 45 death survival 83.5 4.1 82.6 3.9 0.01 1 0 Caughey 2003 2003 Caughey Baron hamsters wt 1 263K 0.01 50 i.c. oral food food curcumin 2% wt/wt 45 death survival 85.4 4.7 82.6 3.9 0.03 1 0 Doh-Ura 2004 2004 Doh-Ura Iwaki mice Tg7 Race 1995 http://www.ncbi.nlm.nih.gov/pubmed/7576660 http://www.ncbi.nlm.nih.gov/pubmed/10623745 hamster wt 4.5 263K 0.01 20 i.c. i.c. pbs water pentosan polysulfate 1ug/kg/day 0.0 0.0 10 38 survival 51.6 51.6 1.8 0.00 1 1 Doh-Ura 2004 2004 Doh-Ura Iwaki mice Tg7 Race 1995 http://www.ncbi.nlm.nih.gov/pubmed/7576660 http://www.ncbi.nlm.nih.gov/pubmed/10623745 hamster wt 4.5 263K 0.01 20 i.c. i.c. pbs water pentosan polysulfate 11ug/kg/day 0.0 0.1 10 38 survival 60.0 51.6 1.8 0.16 1 1 Doh-Ura 2004 2004 Doh-Ura Iwaki mice Tg7 Race 1995 http://www.ncbi.nlm.nih.gov/pubmed/7576660 http://www.ncbi.nlm.nih.gov/pubmed/10623745 hamster wt 4.5 263K 0.01 20 i.c. i.c. pbs water pentosan polysulfate 110ug/kg/day 0.1 0.6 10 38 survival 80.0 51.6 1.8 0.55 0.05 1 Doh-Ura 2004 2004 Doh-Ura Iwaki mice Tg7 Race 1995 http://www.ncbi.nlm.nih.gov/pubmed/7576660 http://www.ncbi.nlm.nih.gov/pubmed/10623745 hamster wt 4.5 263K 0.01 20 i.c. i.c. pbs water pentosan polysulfate 460ug/kg/day 0.5 2.6 10 38 survival 123.0 51.6 1.8 1.38 0.05 0 Doh-Ura 2004 2004 Doh-Ura Iwaki mice Tg7 Race 1995 http://www.ncbi.nlm.nih.gov/pubmed/7576660 http://www.ncbi.nlm.nih.gov/pubmed/10623745 hamster wt 4.5 263K 0.01 20 i.c. i.c. pbs water pentosan polysulfate 1ug/kg/day 0.0 0.0 35 63 survival 51.0 51.0 1.8 0.00 1 1 Doh-Ura 2004 2004 Doh-Ura Iwaki mice Tg7 Race 1995 http://www.ncbi.nlm.nih.gov/pubmed/7576660 http://www.ncbi.nlm.nih.gov/pubmed/10623745 hamster wt 4.5 263K 0.01 20 i.c. i.c. pbs water pentosan polysulfate 11ug/kg/day 0.0 0.1 35 63 survival 51.0 51.0 1.8 0.00 1 1 Doh-Ura 2004 2004 Doh-Ura Iwaki mice Tg7 Race 1995 http://www.ncbi.nlm.nih.gov/pubmed/7576660 http://www.ncbi.nlm.nih.gov/pubmed/10623745 hamster wt 4.5 263K 0.01 20 i.c. i.c. pbs water pentosan polysulfate 110ug/kg/day 0.1 0.6 35 63 survival 51.0 51.0 1.8 0.00 1 1 Doh-Ura 2004 2004 Doh-Ura Iwaki mice Tg7 Race 1995 http://www.ncbi.nlm.nih.gov/pubmed/7576660 http://www.ncbi.nlm.nih.gov/pubmed/10623745 hamster wt 4.5 263K 0.01 20 i.c. i.c. pbs water pentosan polysulfate 460ug/kg/day 0.5 2.6 35 63 survival 87.0 51.0 1.8 0.71 0.05 0 Doh-Ura 2004 2004 Doh-Ura Iwaki mice Tg7 Race 1995 http://www.ncbi.nlm.nih.gov/pubmed/7576660 http://www.ncbi.nlm.nih.gov/pubmed/10623745 hamster wt 4.5 263K 0.01 20 i.c. i.c. pbs water pentosan polysulfate 110ug/kg/day 0.1 0.6 42 70 survival 49.0 49.0 0.00 1 1 Doh-Ura 2004 2004 Doh-Ura Iwaki mice Tg7 Race 1995 http://www.ncbi.nlm.nih.gov/pubmed/7576660 http://www.ncbi.nlm.nih.gov/pubmed/10623745 hamster wt 4.5 263K 0.01 20 i.c. i.c. pbs water pentosan polysulfate 230ug/kg/day 0.2 1.3 42 70 survival 63.0 49.0 0.29 0.05 0 Doh-Ura 2004 2004 Doh-Ura Iwaki mice Tg7 Race 1995 http://www.ncbi.nlm.nih.gov/pubmed/7576660 http://www.ncbi.nlm.nih.gov/pubmed/10623745 hamster wt 4.5 263K 0.01 20 i.c. i.c. pbs water pentosan polysulfate 345ug/kg/day 0.3 2.0 42 70 survival 49.0 49.0 0.00 1 1 Doh-Ura 2004 2004 Doh-Ura Iwaki mice Tg7 Race 1995 http://www.ncbi.nlm.nih.gov/pubmed/7576660 http://www.ncbi.nlm.nih.gov/pubmed/10623745 hamster wt 4.5 263K 0.01 20 i.c. i.c. pbs water pentosan polysulfate 460ug/kg/day 0.5 2.6 42 70 survival 49.0 49.0 0.00 1 1 Doh-Ura 2004 2004 Doh-Ura Iwaki mice Tg7 Race 1995 http://www.ncbi.nlm.nih.gov/pubmed/7576660 http://www.ncbi.nlm.nih.gov/pubmed/10623745 hamster wt 4.5 263K 0.01 20 i.c. i.c. pbs water pentosan polysulfate 110ug/kg/day 0.1 0.6 7 35 survival 75.0 47.0 0.60 0.01 1 Doh-Ura 2004 2004 Doh-Ura Iwaki mice Tg7 Race 1995 http://www.ncbi.nlm.nih.gov/pubmed/7576660 http://www.ncbi.nlm.nih.gov/pubmed/10623745 hamster wt 4.5 263K 0.01 20 i.c. i.c. pbs water pentosan polysulfate 110ug/kg/day 0.1 0.6 21 49 survival 65.0 47.0 0.38 0.01 1 Doh-Ura 2004 2004 Doh-Ura Iwaki mice Tg7 Race 1995 http://www.ncbi.nlm.nih.gov/pubmed/7576660 http://www.ncbi.nlm.nih.gov/pubmed/10623745 hamster wt 4.5 263K 0.01 20 i.c. i.c. pbs water pentosan polysulfate 110ug/kg/day 0.1 0.6 35 63 survival 55.0 47.0 0.17 1 1 Doh-Ura 2004 2004 Doh-Ura Iwaki mice Tg7 Race 1995 http://www.ncbi.nlm.nih.gov/pubmed/7576660 http://www.ncbi.nlm.nih.gov/pubmed/10623745 hamster wt 4.5 263K 0.01 20 i.c. i.c. pbs water pentosan polysulfate 110ug/kg/day 0.1 0.6 42 70 survival 47.0 47.0 0.00 1 1 Doh-Ura 2004 2004 Doh-Ura Iwaki mice Tg7 Race 1995 http://www.ncbi.nlm.nih.gov/pubmed/7576660 http://www.ncbi.nlm.nih.gov/pubmed/10623745 hamster wt 4.5 263K 0.01 20 i.c. i.c. pbs water pentosan polysulfate 460ug/kg/day 0.5 2.6 7 35 survival 122.0 47.0 1.60 0.01 0 Doh-Ura 2004 2004 Doh-Ura Iwaki mice Tg7 Race 1995 http://www.ncbi.nlm.nih.gov/pubmed/7576660 http://www.ncbi.nlm.nih.gov/pubmed/10623745 hamster wt 4.5 263K 0.01 20 i.c. i.c. pbs water pentosan polysulfate 460ug/kg/day 0.5 2.6 21 49 survival 97.0 47.0 1.06 0.01 0 Doh-Ura 2004 2004 Doh-Ura Iwaki mice Tg7 Race 1995 http://www.ncbi.nlm.nih.gov/pubmed/7576660 http://www.ncbi.nlm.nih.gov/pubmed/10623745 hamster wt 4.5 263K 0.01 20 i.c. i.c. pbs water pentosan polysulfate 460ug/kg/day 0.5 2.6 35 63 survival 80.0 47.0 0.70 0.05 1 Doh-Ura 2004 2004 Doh-Ura Iwaki mice Tg7 Race 1995 http://www.ncbi.nlm.nih.gov/pubmed/7576660 http://www.ncbi.nlm.nih.gov/pubmed/10623745 hamster wt 4.5 263K 0.01 20 i.c. i.c. pbs water pentosan polysulfate 460ug/kg/day 0.5 2.6 42 70 survival 47.0 47.0 0.00 1 1 Doh-Ura 2004 2004 Doh-Ura Iwaki mice Tg7 Race 1995 http://www.ncbi.nlm.nih.gov/pubmed/7576660 http://www.ncbi.nlm.nih.gov/pubmed/10623745 hamster wt 4.5 263K 0.01 20 i.c. s.c. pbs water pentosan polysulfate 0.2 mg/kg/day 0.2 1.1 10 38 survival 52.1 2.1 4 51.0 1.8 4 0.02 0 Doh-Ura 2004 2004 Doh-Ura Iwaki mice Tg7 Race 1995 http://www.ncbi.nlm.nih.gov/pubmed/7576660 http://www.ncbi.nlm.nih.gov/pubmed/10623745 hamster wt 4.5 263K 0.01 20 i.c. s.c. pbs water pentosan polysulfate 2 mg/kg/day 2.0 11.4 10 38 survival 53.1 1.6 5 51.0 1.8 4 0.04 0 Doh-Ura 2004 2004 Doh-Ura Iwaki mice Tg7 Race 1995 http://www.ncbi.nlm.nih.gov/pubmed/7576660 http://www.ncbi.nlm.nih.gov/pubmed/10623745 hamster wt 4.5 263K 0.01 20 i.c. s.c. pbs water pentosan polysulfate 20 mg/kg/day 20.0 113.5 10 38 survival 23.8 16.5 5 51.0 1.8 4 -0.53 0 Doh-Ura 2004 2004 Doh-Ura Iwaki mice Tg7 Race 1995 http://www.ncbi.nlm.nih.gov/pubmed/7576660 http://www.ncbi.nlm.nih.gov/pubmed/10623745 hamster wt 4.5 263K 0.01 20 i.c. s.c. pbs water pentosan polysulfate 0.2 mg/kg/day 0.2 1.1 35 63 survival 51.8 1.8 4 51.8 2.0 4 0.00 0 Doh-Ura 2004 2004 Doh-Ura Iwaki mice Tg7 Race 1995 http://www.ncbi.nlm.nih.gov/pubmed/7576660 http://www.ncbi.nlm.nih.gov/pubmed/10623745 hamster wt 4.5 263K 0.01 20 i.c. s.c. pbs water pentosan polysulfate 2 mg/kg/day 2.0 11.4 35 63 survival 50.0 1.8 5 51.8 2.0 4 -0.03 0 Doh-Ura 2004 2004 Doh-Ura Iwaki mice Tg7 Race 1995 http://www.ncbi.nlm.nih.gov/pubmed/7576660 http://www.ncbi.nlm.nih.gov/pubmed/10623745 hamster wt 4.5 263K 0.01 20 i.c. s.c. pbs water pentosan polysulfate 20 mg/kg/day 20.0 113.5 35 63 survival 40.4 3.1 5 51.8 2.0 4 -0.22 0 Doh-Ura 2004 2004 Doh-Ura Iwaki mice Tg7 Race 1995 http://www.ncbi.nlm.nih.gov/pubmed/7576660 http://www.ncbi.nlm.nih.gov/pubmed/10623745 hamster wt 4.5 263K 0.01 20 i.c. i.c. water water amphotericin b 0.9ug/kg/day 0.0 0.0 10 38 survival 51.6 51.6 1.8 0.00 1 1 Doh-Ura 2004 2004 Doh-Ura Iwaki mice Tg7 Race 1995 http://www.ncbi.nlm.nih.gov/pubmed/7576660 http://www.ncbi.nlm.nih.gov/pubmed/10623745 hamster wt 4.5 263K 0.01 20 i.c. i.c. water water amphotericin b 9ug/kg/day 0.0 0.1 10 38 survival 64.0 51.6 1.8 0.24 0.01 0 Doh-Ura 2004 2004 Doh-Ura Iwaki mice Tg7 Race 1995 http://www.ncbi.nlm.nih.gov/pubmed/7576660 http://www.ncbi.nlm.nih.gov/pubmed/10623745 hamster wt 4.5 263K 0.01 20 i.c. i.c. water water amphotericin b 90ug/kg/day 0.1 0.5 10 38 survival 64.0 51.6 1.8 0.24 0.01 0 Doh-Ura 2004 2004 Doh-Ura Iwaki mice Tg7 Race 1995 http://www.ncbi.nlm.nih.gov/pubmed/7576660 http://www.ncbi.nlm.nih.gov/pubmed/10623745 hamster wt 4.5 263K 0.01 20 i.c. i.c. water water amphotericin b 860ug/kg/day 0.9 4.9 10 38 survival 51.6 51.6 1.8 0.00 1 1 Doh-Ura 2004 2004 Doh-Ura Iwaki mice Tg7 Race 1995 http://www.ncbi.nlm.nih.gov/pubmed/7576660 http://www.ncbi.nlm.nih.gov/pubmed/10623745 hamster wt 4.5 263K 0.01 20 i.c. i.c. water water amphotericin b 0.9ug/kg/day 0.0 0.0 35 63 survival 51.6 51.0 1.8 0.01 1 1 Doh-Ura 2004 2004 Doh-Ura Iwaki mice Tg7 Race 1995 http://www.ncbi.nlm.nih.gov/pubmed/7576660 http://www.ncbi.nlm.nih.gov/pubmed/10623745 hamster wt 4.5 263K 0.01 20 i.c. i.c. water water amphotericin b 9ug/kg/day 0.0 0.1 35 63 survival 51.6 51.0 1.8 0.01 1 1 Doh-Ura 2004 2004 Doh-Ura Iwaki mice Tg7 Race 1995 http://www.ncbi.nlm.nih.gov/pubmed/7576660 http://www.ncbi.nlm.nih.gov/pubmed/10623745 hamster wt 4.5 263K 0.01 20 i.c. i.c. water water amphotericin b 90ug/kg/day 0.1 0.5 35 63 survival 51.6 51.0 1.8 0.01 1 1 Doh-Ura 2004 2004 Doh-Ura Iwaki mice Tg7 Race 1995 http://www.ncbi.nlm.nih.gov/pubmed/7576660 http://www.ncbi.nlm.nih.gov/pubmed/10623745 hamster wt 4.5 263K 0.01 20 i.c. i.c. water water amphotericin b 860ug/kg/day 0.9 4.9 35 63 survival 51.6 51.0 1.8 0.01 1 1 Doh-Ura 2004 2004 Doh-Ura Iwaki mice Tg7 Race 1995 http://www.ncbi.nlm.nih.gov/pubmed/7576660 http://www.ncbi.nlm.nih.gov/pubmed/10623745 hamster wt 4.5 263K 0.01 20 i.c. i.c. pbs water quinacrine .7 nmol/kg/day 0.7 0.0 0.0 10 38 survival 51.6 51.6 1.8 0.00 1 1 Doh-Ura 2004 2004 Doh-Ura Iwaki mice Tg7 Race 1995 http://www.ncbi.nlm.nih.gov/pubmed/7576660 http://www.ncbi.nlm.nih.gov/pubmed/10623745 hamster wt 4.5 263K 0.01 20 i.c. i.c. pbs water quinacrine 7 nmol/kg/day 7 0.0 0.0 10 38 survival 51.6 51.6 1.8 0.00 0.01 0 Doh-Ura 2004 2004 Doh-Ura Iwaki mice Tg7 Race 1995 http://www.ncbi.nlm.nih.gov/pubmed/7576660 http://www.ncbi.nlm.nih.gov/pubmed/10623745 hamster wt 4.5 263K 0.01 20 i.c. i.c. pbs water quinacrine 60 nmol/kg/day 60 0.0 0.1 10 38 survival 51.6 51.6 1.8 0.00 0.01 0 Doh-Ura 2004 2004 Doh-Ura Iwaki mice Tg7 Race 1995 http://www.ncbi.nlm.nih.gov/pubmed/7576660 http://www.ncbi.nlm.nih.gov/pubmed/10623745 hamster wt 4.5 263K 0.01 20 i.c. i.c. pbs water quinacrine 510 nmol/kg/day 510 0.2 1.2 10 38 survival 51.6 51.6 1.8 0.00 1 1 Doh-Ura 2004 2004 Doh-Ura Iwaki mice Tg7 Race 1995 http://www.ncbi.nlm.nih.gov/pubmed/7576660 http://www.ncbi.nlm.nih.gov/pubmed/10623745 hamster wt 4.5 263K 0.01 20 i.c. i.c. pbs water quinacrine 5000 nmol/kg/day 5000 2.0 11.4 10 38 survival 51.6 51.6 1.8 0.00 1 1 Doh-Ura 2004 2004 Doh-Ura Iwaki mice Tg7 Race 1995 http://www.ncbi.nlm.nih.gov/pubmed/7576660 http://www.ncbi.nlm.nih.gov/pubmed/10623745 hamster wt 4.5 263K 0.01 20 i.c. i.c. pbs water quinacrine 50000 nmol/kg/day 50000 20.0 113.5 10 38 survival 30.0 51.6 1.8 -0.42 1 Doh-Ura 2004 2004 Doh-Ura Iwaki mice Tg7 Race 1995 http://www.ncbi.nlm.nih.gov/pubmed/7576660 http://www.ncbi.nlm.nih.gov/pubmed/10623745 hamster wt 4.5 263K 0.01 20 i.c. i.c. pbs water quinacrine .7 nmol/kg/day 0.7 0.0 0.0 35 63 survival 51.0 51.0 1.8 0.00 1 1 Doh-Ura 2004 2004 Doh-Ura Iwaki mice Tg7 Race 1995 http://www.ncbi.nlm.nih.gov/pubmed/7576660 http://www.ncbi.nlm.nih.gov/pubmed/10623745 hamster wt 4.5 263K 0.01 20 i.c. i.c. pbs water quinacrine 7 nmol/kg/day 7 0.0 0.0 35 63 survival 51.0 51.0 1.8 0.00 1 1 Doh-Ura 2004 2004 Doh-Ura Iwaki mice Tg7 Race 1995 http://www.ncbi.nlm.nih.gov/pubmed/7576660 http://www.ncbi.nlm.nih.gov/pubmed/10623745 hamster wt 4.5 263K 0.01 20 i.c. i.c. pbs water quinacrine 60 nmol/kg/day 60 0.0 0.1 35 63 survival 51.0 51.0 1.8 0.00 1 1 Doh-Ura 2004 2004 Doh-Ura Iwaki mice Tg7 Race 1995 http://www.ncbi.nlm.nih.gov/pubmed/7576660 http://www.ncbi.nlm.nih.gov/pubmed/10623745 hamster wt 4.5 263K 0.01 20 i.c. i.c. pbs water quinacrine 510 nmol/kg/day 510 0.2 1.2 35 63 survival 51.0 51.0 1.8 0.00 1 1 Doh-Ura 2004 2004 Doh-Ura Iwaki mice Tg7 Race 1995 http://www.ncbi.nlm.nih.gov/pubmed/7576660 http://www.ncbi.nlm.nih.gov/pubmed/10623745 hamster wt 4.5 263K 0.01 20 i.c. i.c. pbs water quinacrine 5000 nmol/kg/day 5000 2.0 11.4 35 63 survival 51.0 51.0 1.8 0.00 1 1 Doh-Ura 2004 2004 Doh-Ura Iwaki mice Tg7 Race 1995 http://www.ncbi.nlm.nih.gov/pubmed/7576660 http://www.ncbi.nlm.nih.gov/pubmed/10623745 hamster wt 4.5 263K 0.01 20 i.c. i.c. pbs water quinacrine 50000 nmol/kg/day 50000 20.0 113.5 35 63 survival 51.0 51.0 1.8 0.00 1 1 Doh-Ura 2004 2004 Doh-Ura Iwaki mice Tg20 Fischer 1996 wt 10 RML 0.01 20 i.c. i.c. pbs water pentosan polysulfate 230 ug/kg/day 0.2 1.3 14 42 survival 141.0 65.0 1.17 0 Doh-Ura 2004 2004 Doh-Ura Iwaki mice Tg20 Fischer 1996 wt 10 RML 0.01 20 i.c. i.c. pbs water pentosan polysulfate 230 ug/kg/day 0.2 1.3 49 77 survival 95.0 65.0 0.46 0 Doh-Ura 2004 2004 Doh-Ura Iwaki mice Tg20 Fischer 1996 wt 10 Fukuoka-1 0.01 20 i.c. i.c. pbs water pentosan polysulfate 230 ug/kg/day 0.2 1.3 14 42 survival 153.0 106.0 0.44 0 Doh-Ura 2004 2004 Doh-Ura Iwaki mice Tg20 Fischer 1996 wt 10 Fukuoka-1 0.01 20 i.c. i.c. pbs water pentosan polysulfate 230 ug/kg/day 0.2 1.3 49 77 survival 133.0 106.0 0.25 0 Manueldis 1998 1998 Manueldis Zaitsev rats wt 1 SY 0.01 50 i.c. oral peanut butter peanut butter indomethacin 3 mg/kg/day 3.0 1 death clinical signs 325.0 4 310.0 8 0.05 0.011 0 Manueldis 1998 1998 Manueldis Zaitsev rats wt 1 SY 0.01 50 i.c. oral peanut butter peanut butter indomethacin 3 mg/kg/day 3.0 1 death survival 344.0 4 344.0 8 0.00 1 1 Manueldis 1998 1998 Manueldis Zaitsev rats wt 1 SY 0.01 50 i.c. oral peanut butter peanut butter dapsone 2 mg/kg/day 2.0 1 death clinical signs 390.0 4 310.0 8 0.26 0.0001 0 Manueldis 1998 1998 Manueldis Zaitsev rats wt 1 SY 0.01 50 i.c. oral peanut butter peanut butter dapsone 2 mg/kg/day 2.0 1 death survival 437.0 4 344.0 8 0.27 0.0001 0 Priola 2000 2000 Priola Caughey mice Tg7 Race 1995 hamster wt 4.5 263K i.p. i.p. dmso dmso DPG2-Fe3+ "3x/week for 4 weeks, dose not stated" 0 28 survival 119.0 35.4 12.5 8 81.6 5.1 18 0.46 0.0001 0 Priola 2000 2000 Priola Caughey mice Tg7 Race 1995 hamster wt 4.5 263K i.p. i.p. dmso dmso DPG2-Fe3+ "3x/week for 4 weeks, dose not stated" 28 56 survival 88.3 8.0 2.4 11 81.6 5.1 18 0.08 0.01 0 Priola 2000 2000 Priola Caughey mice Tg7 Race 1995 hamster wt 4.5 263K i.p. i.p. dmso dmso DPG2-Fe3+ "3x/week for 4 weeks, dose not stated" 56 84 survival 87.4 16.1 4.3 14 81.6 5.1 18 0.07 0.05 0 Priola 2000 2000 Priola Caughey mice Tg7 Race 1995 hamster wt 4.5 263K i.p. i.p. dmso dmso TMPP-Fe3+ "3x/week for 4 weeks, dose not stated" 0 28 survival 171.5 43.4 13.1 11 81.6 5.1 18 1.10 0.0001 0 Priola 2000 2000 Priola Caughey mice Tg7 Race 1995 hamster wt 4.5 263K i.p. i.p. dmso dmso TMPP-Fe3+ "3x/week for 4 weeks, dose not stated" 56 84 survival 84.0 24.0 7.6 10 81.6 5.1 18 0.03 0.68 0 Priola 2000 2000 Priola Caughey mice Tg7 Race 1995 hamster wt 4.5 263K i.p. i.p. dmso dmso PcTS "3x/week for 4 weeks, dose not stated" 0 0 survival 114.0 25.5 8.5 9 81.6 5.1 18 0.40 0.0001 0 Priola 2000 2000 Priola Caughey mice Tg7 Race 1995 hamster wt 4.5 263K i.p. i.p. dmso dmso PcTS "3x/week for 4 weeks, dose not stated" 0 28 survival 216.6 74.2 18.0 17 81.6 5.1 18 1.65 0.0001 0 Priola 2000 2000 Priola Caughey mice Tg7 Race 1995 hamster wt 4.5 263K i.p. i.p. dmso dmso PcTS "3x/week for 4 weeks, dose not stated" 28 56 survival 86.3 7.4 1.8 17 81.6 5.1 18 0.06 0.03 0 Priola 2000 2000 Priola Caughey mice Tg7 Race 1995 hamster wt 4.5 263K i.p. i.p. dmso dmso PcTS "3x/week for 4 weeks, dose not stated" 56 84 survival 75.1 2.8 0.8 12 81.6 5.1 18 -0.08 0.0003 0 Leidel 2011 2011 Leidel Groschup mice C57BL/6 RML i.c. i.p. 100% dmso 100% dmso DPP-1 100 ug/day 5.0 28.4 90 110 survival 174.0 3.8 160.0 4.1 0.09 0.01 0 Leidel 2011 2011 Leidel Groschup mice Tga20 Fischer 1996 wt 10 RML i.p. i.p. 70% dmso 70% dmso DPP-1 100 ug/day 5.0 28.4 90 146 survival 149.0 3.0 112.0 6.6 0.33 0.05 0 treatment start date is never stated; presumably same as 'primary efficiency test' which was 90dpi Leidel 2011 2011 Leidel Groschup mice Tga20 Fischer 1996 wt 10 RML i.p. oral 0.9% NaCl 0.9% NaCl DPP-1 500 ug/day 25.0 141.9 14 death survival 155.0 10.0 113.0 6.4 0.37 0.05 0 Leidel 2011 2011 Leidel Groschup mice C57BL/6 RML i.p. oral 0.9% NaCl 0.9% NaCl DPP-1 500 ug/day 25.0 141.9 -14 death survival 212.0 1.8 192.0 0.5 0.10 0.01 0 Kocisko 2004 2004 cited by Leidel - look this up Geissen 2011 2011 Geissen Groschup mice C57/6 wt 1 RML 0.1 50 i.c. i.p. 100% dmso 100% dmso S9 5 mg/kg/day 5.0 28.4 90 110 survival 173.8 8.6 4.0 157.6 4.9 10 0.10 0.05 0 Geissen 2011 2011 Geissen Groschup mice C57/6 wt 1 RML 0.1 50 i.c. i.p. 100% dmso 100% dmso S14 5 mg/kg/day 5.0 28.4 90 110 survival 170.3 3.8 4.0 157.6 4.9 10 0.08 0.005 0 Eiden 2012 2012 Eiden Groschup mice C57BL/6 wt 1 RML 0.01 30 i.c. oral water water Scutellaria lateriflora 30 g herbs / 1 L water -14 death survival 184.0 26.7 6 147.0 3.1 6 0.25 0.01 0 Eiden 2012 2012 Eiden Groschup mice C57BL/6 wt 1 RML 0.01 50 i.p. oral water water Scutellaria lateriflora 30 g herbs / 1 L water -14 death survival 206.0 8.6 6 191.0 8.6 6 0.08 0.05 0 Chung 2011 2011 Chung Wisniewski mice CD-1 wt 1 139A 60 0.01 100 i.p. i.p. pbs pbs styryl #23I 10 mg/kg/day 10.0 56.8 0 30 survival 202.0 25.0 170 25 0.19 0.0001 0 Chung 2011 2011 Chung Wisniewski mice CD-1 wt 1 139A 60 0.01 100 i.p. i.p. pbs pbs styryl #59 10 mg/kg/day 10.0 56.8 0 30 survival 215.0 25.0 170 25 0.26 0.0001 0 Chung 2011 2011 Chung Wisniewski mice CD-1 wt 1 139A 60 0.01 100 i.p. i.p. pbs pbs trimipramine 10 mg/kg/day 10.0 56.8 0 death survival 210.0 25.0 170 25 0.24 0.0001 0 Chung 2011 2011 Chung Wisniewski mice CD-1 wt 1 139A 60 0.01 100 i.p. i.p. pbs pbs fluphenazine 1 mg/kg/day 1.0 5.7 0 death survival 205.0 25.0 170 25 0.21 0.0005 0 Kawsaski 2007 2007 "also cites ""our previous experiments (14,15) - look these up." Kawasaki Doh-Ura mice Tga20 Fischer 1996 wt 10 RML 35 0.01 20 i.c. oral food food cpd-B .1% wt/wt in feed 150.0 851.4 0 death survival 108.0 2.8 7.0 68.5 5.9 6 0.58 0.01 0 Kawsaski 2007 2007 Kawasaki Doh-Ura mice Tga20 Fischer 1996 wt 10 RML 35 0.01 20 i.c. oral food food cpd-B .13% wt/wt in feed 225.0 1277.0 0 death survival 120.5 10.7 6.0 68.5 5.9 6 0.76 0.01 0 Kawsaski 2007 2007 Kawasaki Doh-Ura mice Tga20 Fischer 1996 wt 10 RML 35 0.01 20 i.c. oral food food cpd-B .2% wt/wt in feed 300.0 1702.7 0 death survival 154.3 19.9 6.0 68.5 5.9 6 1.25 0.01 0 Kawsaski 2007 2007 Kawasaki Doh-Ura mice Tga20 Fischer 1996 wt 10 RML 35 0.01 20 i.c. oral food food cpd-B .2% wt/wt in feed 300.0 1702.7 0 death survival 174.5 7.6 6.0 63.0 1.8 10 1.77 0.01 0 Kawsaski 2007 2007 Kawasaki Doh-Ura mice Tga20 Fischer 1996 wt 10 RML 35 0.01 20 i.c. oral food food cpd-B .2% wt/wt in feed 300.0 1702.7 35 death survival 117.2 7.0 9.0 63.0 1.8 10 0.86 0.01 0 Kawsaski 2007 2007 Kawasaki Doh-Ura mice Tga20 Fischer 1996 wt 10 RML 35 0.01 20 i.c. oral food food cpd-B .2% wt/wt in feed 300.0 1702.7 49 death survival 88.7 17.3 11.0 63.0 1.8 10 0.41 0.01 0 Kawsaski 2007 2007 Kawasaki Doh-Ura mice Tga20 Fischer 1996 wt 10 RML 35 0.01 20 i.c. oral food food cpd-B .2% wt/wt in feed 300.0 1702.7 0 14 survival 102.1 2.9 9.0 63.0 1.8 10 0.62 0.01 0 Kawsaski 2007 2007 Kawasaki Doh-Ura mice Tga20 Fischer 1996 wt 10 RML 35 0.01 20 i.c. oral food food cpd-B .2% wt/wt in feed 300.0 1702.7 0 35 survival 120.2 5.2 9.0 63.0 1.8 10 0.91 0.01 0 Kawsaski 2007 2007 Kawasaki Doh-Ura mice Tga20 Fischer 1996 wt 10 RML 35 0.01 20 i.c. oral food food cpd-B .2% wt/wt in feed 300.0 1702.7 0 70 survival 142.5 7.8 8.0 63.0 1.8 10 1.26 0.01 0 Kawsaski 2007 2007 Kawasaki Doh-Ura mice Tga20 Fischer 1996 wt 10 22L 35 0.01 20 i.c. oral food food cpd-B .2% wt/wt in feed 300.0 1702.7 0 death survival 126.3 10.3 6.0 96.3 5.9 6 0.31 0.01 0 Kawsaski 2007 2007 Kawasaki Doh-Ura mice Tga20 Fischer 1996 wt 10 Fukuoka-1 35 0.01 20 i.c. oral food food cpd-B .2% wt/wt in feed 300.0 1702.7 0 death survival 142.2 21.0 5.0 101.6 12.1 8 0.40 0.01 0 Kawsaski 2007 2007 Kawasaki Doh-Ura mice Tg7 Race 1995 http://www.ncbi.nlm.nih.gov/pubmed/7576660 http://www.ncbi.nlm.nih.gov/pubmed/10623745 hamster wt 4.5 263K 35 0.01 20 i.c. oral food food cpd-B .2% wt/wt in feed 300.0 1702.7 0 death survival 52.7 2.8 11.0 48.0 3.0 6 0.10 0.05 0 Kawsaski 2007 2007 Kawasaki Doh-Ura mice ICR wt 1 RML 35 0.01 20 i.c. oral food food cpd-B .2% wt/wt in feed 300.0 1702.7 0 187 survival 270.0 13.0 154.2 18.4 14 0.75 0.01 1 "It appears mice were not tracked past ~270 dpi. 7 of 13 treated mice were still alive at 270 dpi, making it approximately the median." Kawsaski 2007 2007 Kawasaki Doh-Ura hamsters Syrian wt 1 263K 35 0.01 40 i.c. oral food food cpd-B .2% wt/wt in feed 0 death survival 107.0 2.5 6.0 97.4 6.9 7 0.10 0.05 0