study year pubmed_link full_text_link first_author last_author animal_species animal_strain animal_sex animal_model_name animal_model_citation prnp_genotype prp_expression_level prion_strain avg_age_at_inoculation_days inoculum_titer inoculum_volume_ul ld50_prions infection_route treatment_route vehicle control_compound treatment_class treatment dose_description dose_number_deprecated peak_dose_mgkgday equiv_peak_dose_mg_70kg_human treatment_started_dpi treatment_stopped_dpi endpoint treatment_endpoint_dpi treatment_sd treatment_sem treatment_n treatment_attack_rate censored_dpi control_endpoint_dpi control_sd control_n control_attack_rate delay reported_p eyeballed comments Cortes 2012 2012 http://www.ncbi.nlm.nih.gov/pubmed/22956830 http://www.jneurosci.org/content/32/36/12396.full.pdf Cortes Mastrianni mice - Tg(PrP-A116V) Yang 2009 http://www.ncbi.nlm.nih.gov/pubmed/19675240/ A117V/129V 5 GSS p.o. small molecule rapamycin 10mg/kg 3x/week 4.3 24.3 42 symptomatic 149.0 18.1 3.7 24 1 134.0 11.6 20 1 0.11 0.05 treatment started figures refer to age of mice Cortes 2012 2012 http://www.ncbi.nlm.nih.gov/pubmed/22956830 http://www.jneurosci.org/content/32/36/12396.full.pdf Cortes Mastrianni mice - Tg(PrP-A116V) Yang 2009 http://www.ncbi.nlm.nih.gov/pubmed/19675240/ A117V/129V 5 GSS p.o. small molecule rapamycin 20mg/kg 3x/week 8.6 48.6 42 symptomatic 159.0 20.1 4.2 23 1 134.0 11.6 20 1 0.19 0.0001 treatment started figures refer to age of mice Cortes 2012 2012 http://www.ncbi.nlm.nih.gov/pubmed/22956830 http://www.jneurosci.org/content/32/36/12396.full.pdf Cortes Mastrianni mice - Tg(PrP-A116V) Yang 2009 http://www.ncbi.nlm.nih.gov/pubmed/19675240/ A117V/129V 5 GSS p.o. small molecule rapamycin 10mg/kg 3x/week 4.3 24.3 42 survival 175 16.6 3.8 19 1 173.0 16.5 20 1 0.01 1 treatment started figures refer to age of mice Cortes 2012 2012 http://www.ncbi.nlm.nih.gov/pubmed/22956830 http://www.jneurosci.org/content/32/36/12396.full.pdf Cortes Mastrianni mice - Tg(PrP-A116V) Yang 2009 http://www.ncbi.nlm.nih.gov/pubmed/19675240/ A117V/129V 5 GSS p.o. small molecule rapamycin 20mg/kg 3x/week 8.6 48.6 42 survival 189 15.7 3.8 17 1 173.0 16.5 20 1 0.09 0.018 treatment started figures refer to age of mice Pocchiari 1987 1987 http://www.ncbi.nlm.nih.gov/pubmed/2433387 http://vir.sgmjournals.org/content/68/1/219.full.pdf Pocchiari Masullo hamsters - wt 1 263K 21 0.1 i.c. i.p. .9% NaCl .9% NaCl small molecule amphotericin b 1mg/kg 6x/week (increased from starting dose of 0.1mg/kg) 0.9 8.1 0 50 symptomatic 82.7 5.1 7 1 54.6 4.7 62 1 0.51 0.0001 Pocchiari 1987 1987 http://www.ncbi.nlm.nih.gov/pubmed/2433387 http://vir.sgmjournals.org/content/68/1/219.full.pdf Pocchiari Masullo hamsters - wt 1 263K 21 0.1 i.c. i.p. .9% NaCl .9% NaCl small molecule amphotericin b 1mg/kg 6x/week (increased from starting dose of 0.1mg/kg) 0.9 8.1 0 75 symptomatic 95.9 3.5 8 1 54.6 4.7 62 1 0.76 0.0001 Pocchiari 1987 1987 http://www.ncbi.nlm.nih.gov/pubmed/2433387 http://vir.sgmjournals.org/content/68/1/219.full.pdf Pocchiari Masullo hamsters - wt 1 263K 21 0.1 i.c. i.p. .9% NaCl .9% NaCl small molecule amphotericin b 1mg/kg 6x/week (increased from starting dose of 0.1mg/kg) 0.9 8.1 0 100 symptomatic 101.6 2.2 7 1 54.6 4.7 62 1 0.86 0.0001 Pocchiari 1987 1987 http://www.ncbi.nlm.nih.gov/pubmed/2433387 http://vir.sgmjournals.org/content/68/1/219.full.pdf Pocchiari Masullo hamsters - wt 1 263K 21 0.1 i.c. i.p. .9% NaCl .9% NaCl small molecule amphotericin b 1mg/kg 6x/week (increased from starting dose of 0.1mg/kg) 0.9 8.1 55 symptomatic 68.7 10 1 68.9 7 1 0.00 1 "treated from onset of ""clinical signs"" (score 3), which occurred at 54.6 +/- 4.7 dpi. tested delay from clinical onset (score 3) to ""advanced clinical signs"" (score 4). animals were not sacrified until ""advanced stage of disease"" (score 4)" Pocchiari 1987 1987 http://www.ncbi.nlm.nih.gov/pubmed/2433387 http://vir.sgmjournals.org/content/68/1/219.full.pdf Pocchiari Masullo hamsters - wt 1 263K 21 0.1 i.p. i.p. .9% NaCl .9% NaCl small molecule amphotericin b 1mg/kg 6x/week (increased from starting dose of 0.1mg/kg) 0.9 8.1 0 50 symptomatic 162.8 31.3 5 1 107.2 6.9 5 1 0.52 Pocchiari 1989 1989 http://www.ncbi.nlm.nih.gov/pubmed/2509571 Pocchiari Ladogana hamsters - wt 1 263K 0.1 50 i.c. i.p. sodium deoxycholate in phosphate buffer sodium deoxycholate in phosphate buffer small molecule amphotericin b 1 mg/kg 6x/wk 0.9 8.1 -14 0 symptomatic 71.1 2.3 9 1 51.2 1.3 9 1 0.39 0.001 Pocchiari 1989 1989 http://www.ncbi.nlm.nih.gov/pubmed/2509571 Pocchiari Ladogana hamsters - wt 1 263K 0.1 50 i.c. i.p. sodium deoxycholate in phosphate buffer sodium deoxycholate in phosphate buffer small molecule amphotericin b 1 mg/kg 6x/wk 0.9 8.1 0 7 symptomatic 64.9 1.7 8 1 51.2 1.3 9 1 0.27 0.001 Pocchiari 1989 1989 http://www.ncbi.nlm.nih.gov/pubmed/2509571 Pocchiari Ladogana hamsters - wt 1 263K 0.1 50 i.c. i.p. sodium deoxycholate in phosphate buffer sodium deoxycholate in phosphate buffer small molecule amphotericin b 1 mg/kg 6x/wk 0.9 8.1 7 14 symptomatic 56.5 1.0 8 1 51.2 1.3 9 1 0.10 0.01 Pocchiari 1989 1989 http://www.ncbi.nlm.nih.gov/pubmed/2509571 Pocchiari Ladogana hamsters - wt 1 263K 0.1 50 i.c. i.p. sodium deoxycholate in phosphate buffer sodium deoxycholate in phosphate buffer small molecule amphotericin b 1 mg/kg 6x/wk 0.9 8.1 21 28 symptomatic 57.1 1.5 8 1 51.2 1.3 9 1 0.12 0.01 Pocchiari 1989 1989 http://www.ncbi.nlm.nih.gov/pubmed/2509571 Pocchiari Ladogana hamsters - wt 1 263K 0.1 50 i.c. i.p. sodium deoxycholate in phosphate buffer sodium deoxycholate in phosphate buffer small molecule amphotericin b 1 mg/kg 6x/wk 0.9 8.1 28 35 symptomatic 52.8 0.4 8 1 51.2 1.3 9 1 0.03 1 Pocchiari 1989 1989 http://www.ncbi.nlm.nih.gov/pubmed/2509571 Pocchiari Ladogana hamsters - wt 1 263K 0.1 50 i.c. i.p. sodium deoxycholate in phosphate buffer sodium deoxycholate in phosphate buffer small molecule amphotericin b 0.1 mg/kg 6x/wk 0.1 0.8 0 50 symptomatic 70.4 2.0 8 1 56.7 0.5 14 1 0.24 0.001 Pocchiari 1989 1989 http://www.ncbi.nlm.nih.gov/pubmed/2509571 Pocchiari Ladogana hamsters - wt 1 263K 0.1 50 i.c. i.p. sodium deoxycholate in phosphate buffer sodium deoxycholate in phosphate buffer small molecule amphotericin b 1 mg/kg 6x/wk 0.9 8.1 0 50 symptomatic 78.3 2.2 7 1 56.7 0.5 14 1 0.38 0.001 Pocchiari 1989 1989 http://www.ncbi.nlm.nih.gov/pubmed/2509571 Pocchiari Ladogana hamsters - wt 1 263K 0.1 50 i.c. i.p. sodium deoxycholate in phosphate buffer sodium deoxycholate in phosphate buffer small molecule amphotericin b 5 mg/kg 6x/wk 4.3 40.5 0 50 symptomatic 89.1 1.1 8 1 56.7 0.5 14 1 0.57 0.001 Pocchiari 1989 1989 http://www.ncbi.nlm.nih.gov/pubmed/2509571 Pocchiari Ladogana hamsters - wt 1 263K 0.1 50 i.c. i.p. sodium deoxycholate in phosphate buffer sodium deoxycholate in phosphate buffer small molecule amphotericin b 10 mg/kg 6x/wk 8.6 81.1 0 10 symptomatic 77.8 1.4 4 1 56.7 0.5 14 1 0.37 0.001 half (4/8) the mice died of the AmB dose Pocchiari 1989 1989 http://www.ncbi.nlm.nih.gov/pubmed/2509571 Pocchiari Ladogana hamsters - wt 1 263K 0.1 50 i.p. i.p. sodium deoxycholate in phosphate buffer sodium deoxycholate in phosphate buffer small molecule amphotericin b 1 mg/kg 6x/wk 0.9 8.1 40 122.3 symptomatic 122.3 8.1 7 1 104.6 2.3 1 0.17 0.05 Pocchiari 1989 1989 http://www.ncbi.nlm.nih.gov/pubmed/2509571 Pocchiari Ladogana hamsters - wt 1 263K 0.1 50 i.p. i.p. sodium deoxycholate in phosphate buffer sodium deoxycholate in phosphate buffer small molecule amphotericin b 1 mg/kg 6x/wk 0.9 8.1 50 111.2 symptomatic 111.2 7.3 7 1 104.6 2.3 1 0.06 1 Pocchiari 1989 1989 http://www.ncbi.nlm.nih.gov/pubmed/2509571 Pocchiari Ladogana hamsters - wt 1 263K 0.1 50 i.p. i.p. sodium deoxycholate in phosphate buffer sodium deoxycholate in phosphate buffer small molecule amphotericin b 1 mg/kg 6x/wk 0.9 8.1 60 100.9 symptomatic 100.9 4.7 7 1 104.6 2.3 1 -0.04 1 Pocchiari 1989 1989 http://www.ncbi.nlm.nih.gov/pubmed/2509571 Pocchiari Ladogana hamsters - wt 1 263K 0.1 50 i.c. i.p. diluted saline diluted saline small molecule mepartricin .025 mg/kg 6x/wk 0.021 0.2 0 50 symptomatic 65.4 1.9 9 1 60.7 0.8 18 1 0.08 1 Pocchiari 1989 1989 http://www.ncbi.nlm.nih.gov/pubmed/2509571 Pocchiari Ladogana hamsters - wt 1 263K 0.1 50 i.c. i.p. diluted saline diluted saline small molecule mepartricin .25 mg/kg 6x/wk 0.2 2.0 0 50 symptomatic 61.7 2.2 9 1 60.7 0.8 18 1 0.02 1 Pocchiari 1989 1989 http://www.ncbi.nlm.nih.gov/pubmed/2509571 Pocchiari Ladogana hamsters - wt 1 263K 0.1 50 i.c. i.p. diluted saline diluted saline small molecule mepartricin 1 mg/kg 6x/wk 0.9 8.1 0 50 symptomatic 59.0 0.1 8 1 60.7 0.8 18 1 -0.03 1 Pocchiari 1989 1989 http://www.ncbi.nlm.nih.gov/pubmed/2509571 Pocchiari Ladogana hamsters - wt 1 263K 0.1 50 i.p. i.p. diluted saline diluted saline small molecule mepartricin .25 mg/kg 6x/wk 0.2 2.0 0 50 symptomatic 100.8 10.7 6 1 91.2 2.4 18 1 0.11 1 Pocchiari 1989 1989 http://www.ncbi.nlm.nih.gov/pubmed/2509571 Pocchiari Ladogana hamsters - wt 1 263K 0.1 50 i.p. i.p. diluted saline diluted saline small molecule mepartricin 1 mg/kg 6x/wk 0.9 8.1 0 50 symptomatic 112.8 8.3 5 1 91.2 2.4 18 1 0.24 0.005 Xi 1992 1992 http://www.ncbi.nlm.nih.gov/pubmed/1348570 Xi Pocchiari hamsters - wt 1 263K 21 0.1 50 i.c. i.p. sodium deoxycholate in phosphate buffer small molecule amphotericin b 1 mg/kg 6x/wk 0.9 8.1 1 98.6 symptomatic 98.6 2.7 9 1 56.6 3.7 17 1 0.74 0.001 Xi 1992 1992 http://www.ncbi.nlm.nih.gov/pubmed/1348570 Xi Pocchiari hamsters - wt 1 139H 21 0.1 50 i.c. i.p. sodium deoxycholate in phosphate buffer small molecule amphotericin b 1 mg/kg 6x/wk 0.9 8.1 0 130 symptomatic 138.2 1.0 13 1 138.1 3.3 20 1 0.00 1 Xi 1992 1992 http://www.ncbi.nlm.nih.gov/pubmed/1348570 Xi Pocchiari mice Swiss wt 1 139A 0.1 30 i.c. i.p. sodium deoxycholate in phosphate buffer small molecule amphotericin b 3 mg/kg 6x/wk 2.6 14.6 0 90 symptomatic 131.9 7.3 12 1 131.4 3.9 17 1 0.00 1 McKenzie 1994 1994 http://www.ncbi.nlm.nih.gov/pubmed/7933137/ http://www.ncbi.nlm.nih.gov/pmc/articles/PMC237196/pdf/jvirol00020-0722.pdf McKenzie Aiken hamsters Syrian wt 1 263K 0.01 50 i.c. i.p. small molecule amphotericin b 1 mg/kg 6x/wk 0.9 8.1 1 symptomatic 87.5 4.8 25 1 61.7 2.6 19 1 0.42 0.0005 Time when treatment was stopped is not stated. McKenzie 1994 1994 http://www.ncbi.nlm.nih.gov/pubmed/7933137/ http://www.ncbi.nlm.nih.gov/pmc/articles/PMC237196/pdf/jvirol00020-0722.pdf McKenzie Aiken hamsters Syrian wt 1 263K 0.01 50 i.c. i.p. small molecule amphotericin b 1 mg/kg 6x/wk 0.9 8.1 1 survival 107.0 3.1 16 1 83.7 2.8 12 1 0.28 0.0005 Time when treatment was stopped is not stated. Demaimay 1994 1994 http://www.ncbi.nlm.nih.gov/pubmed/7915757 http://vir.sgmjournals.org/content/75/9/2499.full.pdf Demaimay Dormont hamsters Syrian wt 1 263K 0.01 50 i.c. i.p. 5% w/v glucose solution see comments small molecule amphotericin b 2.5 mg/kg/day 2.1 20.3 0 7 survival 98.7 0.7 3 1 84.0 5 1 0.18 0.03 averaged NMG (88 dpi) and untreated controls (81.3 dpi) which were not significantly different from each other Demaimay 1994 1994 http://www.ncbi.nlm.nih.gov/pubmed/7915757 http://vir.sgmjournals.org/content/75/9/2499.full.pdf Demaimay Dormont hamsters Syrian wt 1 263K 0.01 50 i.c. i.p. NMG in 5% wt/vol glucose solution see comments small molecule MS-8209 2.5 mg/kg/day 2.1 20.3 0 7 survival 100.7 0.3 3 1 84.0 5 1 0.20 0.03 averaged NMG and untreated controls which were not significantly different from each other Demaimay 1994 1994 http://www.ncbi.nlm.nih.gov/pubmed/7915757 http://vir.sgmjournals.org/content/75/9/2499.full.pdf Demaimay Dormont mice - wt 1 C506M3 0.01 20 i.c. i.p. 5% w/v glucose solution untreated small molecule amphotericin b 2.5 mg/kg/day 2.1 12.2 0 survival 222.7 7.1 6 1 170.7 2.3 3 1 0.30 0.03 "control average (n=3) was duplicated in 24 other mice, ""data not shown""" Demaimay 1994 1994 http://www.ncbi.nlm.nih.gov/pubmed/7915757 http://vir.sgmjournals.org/content/75/9/2499.full.pdf Demaimay Dormont mice - wt 1 C506M3 0.01 20 i.c. i.p. NMG in 5% wt/vol glucose solution untreated small molecule MS-8209 2.5 mg/kg/day 2.1 12.2 0 survival 214.8 16.6 6 1 170.7 2.3 3 1 0.26 0.03 "control average (n=3) was duplicated in 24 other mice, ""data not shown""" Demaimay 1994 1994 http://www.ncbi.nlm.nih.gov/pubmed/7915757 http://vir.sgmjournals.org/content/75/9/2499.full.pdf Demaimay Dormont mice - wt 1 C506M3 0.01 80 i.c. i.p. NMG in 5% wt/vol glucose solution see comments small molecule MS-8209 .25 mg/kg/day 0.2 1.2 -7 40 survival 330.0 3.9 6 1 329.6 6.7 6 1 0.00 1 averaged NMG (88 dpi) and untreated controls (81.3 dpi) which were not significantly different from each other Demaimay 1994 1994 http://www.ncbi.nlm.nih.gov/pubmed/7915757 http://vir.sgmjournals.org/content/75/9/2499.full.pdf Demaimay Dormont mice - wt 1 C506M3 0.01 80 i.c. i.p. NMG in 5% wt/vol glucose solution see comments small molecule MS-8209 2.5 mg/kg/day 2.1 12.2 -7 40 survival 349.3 9.5 5 1 329.6 6.7 6 1 0.06 0.04 averaged NMG and untreated controls which were not significantly different from each other Demaimay 1994 1994 http://www.ncbi.nlm.nih.gov/pubmed/7915757 http://vir.sgmjournals.org/content/75/9/2499.full.pdf Demaimay Dormont mice - wt 1 C506M3 0.01 80 i.c. i.p. small molecule MS-8209 25 mg/kg/day 21.4 121.6 -7 40 survival 357.1 7.5 12 1 332.7 6.7 6 1 0.07 0.001 Adjou 1995 1995 http://www.ncbi.nlm.nih.gov/pubmed/8593027/ http://www.ncbi.nlm.nih.gov/pmc/articles/PMC163037/pdf/392810.pdf Adjou Dormont hamsters Syrian wt 1 263K 0.01 50 i.c. i.p. small molecule amphotericin b 2.5 mg/kg 6x/wk 2.5 2.1 20.3 0 survival 144.0 1.7 1 86.6 1.3 1 0.66 0.005 Adjou 1995 1995 http://www.ncbi.nlm.nih.gov/pubmed/8593027/ http://www.ncbi.nlm.nih.gov/pmc/articles/PMC163037/pdf/392810.pdf Adjou Dormont hamsters Syrian wt 1 263K 0.01 50 i.c. i.p. small molecule MS-8209 2.5 mg/kg 6x/wk 2.5 2.1 20.3 0 survival 151.5 0.7 1 86.6 1.3 1 0.75 0.005 Adjou 1995 1995 http://www.ncbi.nlm.nih.gov/pubmed/8593027/ http://www.ncbi.nlm.nih.gov/pmc/articles/PMC163037/pdf/392810.pdf Adjou Dormont hamsters Syrian wt 1 263K 0.01 50 i.c. i.p. small molecule MS-8209 10 mg/kg 6x/wk 10 8.6 81.1 0 survival 171.0 1.0 1 86.6 1.3 1 0.97 0.005 Adjou 1995 1995 http://www.ncbi.nlm.nih.gov/pubmed/8593027/ http://www.ncbi.nlm.nih.gov/pmc/articles/PMC163037/pdf/392810.pdf Adjou Dormont hamsters Syrian wt 1 263K 0.01 50 i.c. i.p. small molecule MS-8209 25 mg/kg 6x/wk 25 21.4 202.7 0 survival 171.1 1.2 1 86.6 1.3 1 0.98 0.005 Adjou 1995 1995 http://www.ncbi.nlm.nih.gov/pubmed/8593027/ http://www.ncbi.nlm.nih.gov/pmc/articles/PMC163037/pdf/392810.pdf Adjou Dormont hamsters Syrian wt 1 263K 0.01 50 i.c. i.p. small molecule amphotericin b 1 mg/kg 6x/wk 1 0.9 8.1 -14 0 survival 106.0 6 1 87.0 12 1 0.22 1 numbers estimated from visual in Fig1A Adjou 1995 1995 http://www.ncbi.nlm.nih.gov/pubmed/8593027/ http://www.ncbi.nlm.nih.gov/pmc/articles/PMC163037/pdf/392810.pdf Adjou Dormont hamsters Syrian wt 1 263K 0.01 50 i.c. i.p. small molecule amphotericin b 2.5 mg/kg 6x/wk 2.5 2.1 20.3 0 6 survival 100.0 6 1 87.0 12 1 0.15 1 numbers estimated from visual in Fig1A Adjou 1995 1995 http://www.ncbi.nlm.nih.gov/pubmed/8593027/ http://www.ncbi.nlm.nih.gov/pmc/articles/PMC163037/pdf/392810.pdf Adjou Dormont hamsters Syrian wt 1 263K 0.01 50 i.c. i.p. small molecule MS-8209 2.5 mg/kg 6x/wk 2.5 2.1 20.3 0 6 survival 102.0 6 1 87.0 12 1 0.17 1 numbers estimated from visual in Fig1A Adjou 1995 1995 http://www.ncbi.nlm.nih.gov/pubmed/8593027/ http://www.ncbi.nlm.nih.gov/pmc/articles/PMC163037/pdf/392810.pdf Adjou Dormont hamsters Syrian wt 1 263K 0.01 50 i.c. i.p. small molecule MS-8209 2.5 mg/kg 6x/wk 2.5 2.1 20.3 -14 0 survival 104.0 6 1 87.0 12 1 0.20 1 numbers estimated from visual in Fig1A Adjou 1995 1995 http://www.ncbi.nlm.nih.gov/pubmed/8593027/ http://www.ncbi.nlm.nih.gov/pmc/articles/PMC163037/pdf/392810.pdf Adjou Dormont hamsters Syrian wt 1 263K 0.01 50 i.c. i.p. small molecule MS-8209 25 mg/kg 6x/wk 25 21.4 202.7 0 6 survival 120.0 6 1 87.0 12 1 0.38 1 numbers estimated from visual in Fig1A Adjou 1995 1995 http://www.ncbi.nlm.nih.gov/pubmed/8593027/ http://www.ncbi.nlm.nih.gov/pmc/articles/PMC163037/pdf/392810.pdf Adjou Dormont hamsters Syrian wt 1 263K 0.01 50 i.c. i.p. small molecule MS-8209 25 mg/kg 6x/wk 25 21.4 202.7 -14 0 survival 118.0 6 1 87.0 12 1 0.36 1 numbers estimated from visual in Fig1A Adjou 1995 1995 http://www.ncbi.nlm.nih.gov/pubmed/8593027/ http://www.ncbi.nlm.nih.gov/pmc/articles/PMC163037/pdf/392810.pdf Adjou Dormont hamsters Syrian wt 1 263K 0.01 50 i.c. i.p. small molecule MS-8209 25 mg/kg 6x/wk 25 21.4 202.7 -7 7 survival 122.0 6 1 87.0 12 1 0.40 1 numbers estimated from visual in Fig1A Adjou 1995 1995 http://www.ncbi.nlm.nih.gov/pubmed/8593027/ http://www.ncbi.nlm.nih.gov/pmc/articles/PMC163037/pdf/392810.pdf Adjou Dormont hamsters Syrian wt 1 263K 0.01 50 i.c. i.p. small molecule amphotericin b 50 mg/kg one-time dose 50 42.9 405.4 0 0 survival 110.0 4 1 87.0 12 1 0.26 1 numbers estimated from visual in Fig1A; some mice died of toxicity Adjou 1995 1995 http://www.ncbi.nlm.nih.gov/pubmed/8593027/ http://www.ncbi.nlm.nih.gov/pmc/articles/PMC163037/pdf/392810.pdf Adjou Dormont hamsters Syrian wt 1 263K 0.01 50 i.c. i.p. small molecule MS-8209 50 mg/kg one-time dose 50 42.9 405.4 0 0 survival 108.0 4 1 87.0 12 1 0.24 1 numbers estimated from visual in Fig1A; some mice died of toxicity Adjou 1995 1995 http://www.ncbi.nlm.nih.gov/pubmed/8593027/ http://www.ncbi.nlm.nih.gov/pmc/articles/PMC163037/pdf/392810.pdf Adjou Dormont hamsters Syrian wt 1 263K 0.01 50 i.c. i.p. small molecule MS-8209 100 mg/kg one-time dose 100 85.7 810.8 0 0 survival 111.0 4 1 87.0 12 1 0.28 1 numbers estimated from visual in Fig1A; some mice died of toxicity Demaimay 1997 1997 http://www.ncbi.nlm.nih.gov/pubmed/9371634/ http://www.ncbi.nlm.nih.gov/pmc/articles/PMC230278/pdf/719685.pdf Demaimay Dormont hamsters Syrian wt 1 C506M3 0.01 20 i.c. i.p. small molecule amphotericin b 2.5 mg/kg 6x/wk 2.5 2.1 20.3 90 120 survival 169.7 3.1 5 1 159.8 2.5 4 1 0.06 1 0 Demaimay 1997 1997 http://www.ncbi.nlm.nih.gov/pubmed/9371634/ http://www.ncbi.nlm.nih.gov/pmc/articles/PMC230278/pdf/719685.pdf Demaimay Dormont hamsters Syrian wt 1 C506M3 0.01 20 i.c. i.p. small molecule MS-8209 2.5 mg/kg 6x/wk 2.5 2.1 20.3 90 120 survival 176.0 4.4 5 1 159.8 2.5 4 1 0.10 0.01 0 Demaimay 1997 1997 http://www.ncbi.nlm.nih.gov/pubmed/9371634/ http://www.ncbi.nlm.nih.gov/pmc/articles/PMC230278/pdf/719685.pdf Demaimay Dormont hamsters Syrian wt 1 C506M3 0.01 20 i.c. i.p. small molecule amphotericin b 2.5 mg/kg 6x/wk 2.5 2.1 20.3 90 120 survival 179.9 6.3 8 1 169.4 4.7 11 1 0.06 0.01 0 Demaimay 1997 1997 http://www.ncbi.nlm.nih.gov/pubmed/9371634/ http://www.ncbi.nlm.nih.gov/pmc/articles/PMC230278/pdf/719685.pdf Demaimay Dormont hamsters Syrian wt 1 C506M3 0.01 20 i.c. i.p. small molecule MS-8209 2.5 mg/kg 6x/wk 2.5 2.1 20.3 90 120 survival 178.7 4.3 7 1 169.4 4.7 11 1 0.05 0.01 0 Demaimay 1997 1997 http://www.ncbi.nlm.nih.gov/pubmed/9371634/ http://www.ncbi.nlm.nih.gov/pmc/articles/PMC230278/pdf/719685.pdf Demaimay Dormont hamsters Syrian wt 1 C506M3 0.01 20 i.c. i.p. small molecule MS-8209 25 mg/kg 6x/wk 25 21.4 202.7 90 120 survival 190.6 9.1 7 1 169.4 4.7 11 1 0.13 0.01 0 Demaimay 1997 1997 http://www.ncbi.nlm.nih.gov/pubmed/9371634/ http://www.ncbi.nlm.nih.gov/pmc/articles/PMC230278/pdf/719685.pdf Demaimay Dormont hamsters Syrian wt 1 C506M3 0.01 20 i.c. i.p. small molecule amphotericin b 1 mg/kg 6x/wk 1 0.9 8.1 80 survival 187.0 1.4 8 1 158.0 3.1 6 1 0.18 0.01 0 Demaimay 1997 1997 http://www.ncbi.nlm.nih.gov/pubmed/9371634/ http://www.ncbi.nlm.nih.gov/pmc/articles/PMC230278/pdf/719685.pdf Demaimay Dormont hamsters Syrian wt 1 C506M3 0.01 20 i.c. i.p. small molecule amphotericin b 2.5 mg/kg 6x/wk 2.5 2.1 20.3 80 survival 196.0 2.3 8 1 158.0 3.1 6 1 0.24 0.01 0 Demaimay 1997 1997 http://www.ncbi.nlm.nih.gov/pubmed/9371634/ http://www.ncbi.nlm.nih.gov/pmc/articles/PMC230278/pdf/719685.pdf Demaimay Dormont hamsters Syrian wt 1 C506M3 0.01 20 i.c. i.p. small molecule MS-8209 1 mg/kg 6x/wk 1 0.9 8.1 80 survival 187.0 2.4 8 1 158.0 3.1 6 1 0.18 0.01 0 Demaimay 1997 1997 http://www.ncbi.nlm.nih.gov/pubmed/9371634/ http://www.ncbi.nlm.nih.gov/pmc/articles/PMC230278/pdf/719685.pdf Demaimay Dormont hamsters Syrian wt 1 C506M3 0.01 20 i.c. i.p. small molecule MS-8209 2.5 mg/kg 6x/wk 2.5 2.1 20.3 80 survival 198.0 1.3 8 1 158.0 3.1 6 1 0.25 0.01 0 Demaimay 1997 1997 http://www.ncbi.nlm.nih.gov/pubmed/9371634/ http://www.ncbi.nlm.nih.gov/pmc/articles/PMC230278/pdf/719685.pdf Demaimay Dormont hamsters Syrian wt 1 C506M3 0.01 20 i.c. i.p. small molecule MS-8209 25 mg/kg 6x/wk 25 21.4 202.7 80 survival 221.0 4.1 8 1 158.0 3.1 6 1 0.40 0.01 0 Demaimay 1997 1997 http://www.ncbi.nlm.nih.gov/pubmed/9371634/ http://www.ncbi.nlm.nih.gov/pmc/articles/PMC230278/pdf/719685.pdf Demaimay Dormont hamsters Syrian wt 1 C506M3 0.01 20 i.c. i.p. small molecule amphotericin b 1 mg/kg 6x/wk 1 0.9 8.1 110 survival 182.0 1.4 8 1 160.0 2.5 6 1 0.14 0.01 0 Demaimay 1997 1997 http://www.ncbi.nlm.nih.gov/pubmed/9371634/ http://www.ncbi.nlm.nih.gov/pmc/articles/PMC230278/pdf/719685.pdf Demaimay Dormont hamsters Syrian wt 1 C506M3 0.01 20 i.c. i.p. small molecule amphotericin b 2.5 mg/kg 6x/wk 2.5 2.1 20.3 110 survival 182.0 1.6 8 1 160.0 2.5 6 1 0.14 0.01 0 Demaimay 1997 1997 http://www.ncbi.nlm.nih.gov/pubmed/9371634/ http://www.ncbi.nlm.nih.gov/pmc/articles/PMC230278/pdf/719685.pdf Demaimay Dormont hamsters Syrian wt 1 C506M3 0.01 20 i.c. i.p. small molecule MS-8209 1 mg/kg 6x/wk 1 0.9 8.1 110 survival 173.0 3.1 8 1 160.0 2.5 6 1 0.08 0.01 0 Demaimay 1997 1997 http://www.ncbi.nlm.nih.gov/pubmed/9371634/ http://www.ncbi.nlm.nih.gov/pmc/articles/PMC230278/pdf/719685.pdf Demaimay Dormont hamsters Syrian wt 1 C506M3 0.01 20 i.c. i.p. small molecule MS-8209 2.5 mg/kg 6x/wk 2.5 2.1 20.3 110 survival 180.0 1.3 8 1 160.0 2.5 6 1 0.13 0.01 0 Demaimay 1997 1997 http://www.ncbi.nlm.nih.gov/pubmed/9371634/ http://www.ncbi.nlm.nih.gov/pmc/articles/PMC230278/pdf/719685.pdf Demaimay Dormont hamsters Syrian wt 1 C506M3 0.01 20 i.c. i.p. small molecule MS-8209 25 mg/kg 6x/wk 25 21.4 202.7 110 survival 190.0 2.2 8 1 160.0 2.5 6 1 0.19 0.01 0 Demaimay 1997 1997 http://www.ncbi.nlm.nih.gov/pubmed/9371634/ http://www.ncbi.nlm.nih.gov/pmc/articles/PMC230278/pdf/719685.pdf Demaimay Dormont hamsters Syrian wt 1 C506M3 0.01 20 i.c. i.p. small molecule amphotericin b 1 mg/kg 6x/wk 1 0.9 8.1 140 survival 164.0 2.2 12 1 157.0 1.2 6 1 0.04 0.05 0 some mice died of toxicity Demaimay 1997 1997 http://www.ncbi.nlm.nih.gov/pubmed/9371634/ http://www.ncbi.nlm.nih.gov/pmc/articles/PMC230278/pdf/719685.pdf Demaimay Dormont hamsters Syrian wt 1 C506M3 0.01 20 i.c. i.p. small molecule amphotericin b 2.5 mg/kg 6x/wk 2.5 2.1 20.3 140 survival 167.0 2.5 11 1 157.0 1.2 6 1 0.06 0.05 0 some mice died of toxicity Demaimay 1997 1997 http://www.ncbi.nlm.nih.gov/pubmed/9371634/ http://www.ncbi.nlm.nih.gov/pmc/articles/PMC230278/pdf/719685.pdf Demaimay Dormont hamsters Syrian wt 1 C506M3 0.01 20 i.c. i.p. small molecule MS-8209 1 mg/kg 6x/wk 1 0.9 8.1 140 survival 164.0 2.1 10 1 157.0 1.2 6 1 0.04 1 0 Demaimay 1997 1997 http://www.ncbi.nlm.nih.gov/pubmed/9371634/ http://www.ncbi.nlm.nih.gov/pmc/articles/PMC230278/pdf/719685.pdf Demaimay Dormont hamsters Syrian wt 1 C506M3 0.01 20 i.c. i.p. small molecule MS-8209 2.5 mg/kg 6x/wk 2.5 2.1 20.3 140 survival 165.0 2.2 11 1 157.0 1.2 6 1 0.05 0.05 0 some mice died of toxicity Demaimay 1997 1997 http://www.ncbi.nlm.nih.gov/pubmed/9371634/ http://www.ncbi.nlm.nih.gov/pmc/articles/PMC230278/pdf/719685.pdf Demaimay Dormont hamsters Syrian wt 1 C506M3 0.01 20 i.c. i.p. small molecule MS-8209 25 mg/kg 6x/wk 25 21.4 202.7 140 survival 172.0 3.4 12 1 157.0 1.2 6 1 0.10 0.05 0 some mice died of toxicity Adjou 1999 1999 http://www.ncbi.nlm.nih.gov/pubmed/10211979 http://vir.sgmjournals.org/content/80/4/1079.full.pdf Adjou Dormont hamsters Syrian wt 1 263K 0.01 50 i.c. i.p. small molecule amphotericin b 1 mg/kg 6x/wk 1 0.9 8.1 0 survival 1 1 0.46 0 Adjou 1999 1999 http://www.ncbi.nlm.nih.gov/pubmed/10211979 http://vir.sgmjournals.org/content/80/4/1079.full.pdf Adjou Dormont hamsters Syrian wt 1 263K 0.01 50 i.c. i.p. small molecule amphotericin b 2.5 mg/kg 6x/wk 2.5 2.1 20.3 0 survival 1 1 0.66 0 Adjou 1999 1999 http://www.ncbi.nlm.nih.gov/pubmed/10211979 http://vir.sgmjournals.org/content/80/4/1079.full.pdf Adjou Dormont hamsters Syrian wt 1 263K 0.01 50 i.c. i.p. small molecule MS-8209 2.5 mg/kg 6x/wk 2.5 2.1 20.3 0 survival 1 1 0.75 0 Adjou 1999 1999 http://www.ncbi.nlm.nih.gov/pubmed/10211979 http://vir.sgmjournals.org/content/80/4/1079.full.pdf Adjou Dormont hamsters Syrian wt 1 263K 0.01 50 i.c. i.p. small molecule MS-8209 10 mg/kg 6x/wk 10 8.6 81.1 0 survival 1 1 1.00 0 Adjou 1999 1999 http://www.ncbi.nlm.nih.gov/pubmed/10211979 http://vir.sgmjournals.org/content/80/4/1079.full.pdf Adjou Dormont hamsters Syrian wt 1 263K 0.01 50 i.c. i.p. small molecule MS-8209 25 mg/kg 6x/wk 25 21.4 202.7 0 survival 1 1 1.00 0 Adjou 2000 2000 http://www.ncbi.nlm.nih.gov/pubmed/10627386 Adjou Dormont hamsters Syrian wt 1 263K 0.01 50 i.c. i.p. small molecule amphotericin b 2.5 mg/kg 6x/wk 2.5 2.1 20.3 30 survival 99.0 1.4 7 1 80.0 1.2 5 1 0.24 0.01 0 Adjou 2000 2000 http://www.ncbi.nlm.nih.gov/pubmed/10627386 Adjou Dormont hamsters Syrian wt 1 263K 0.01 50 i.c. i.p. small molecule MS-8209 10 mg/kg 6x/wk 10 8.6 81.1 30 survival 116.0 0.9 6 1 80.0 1.2 5 1 0.45 0.01 0 Adjou 2000 2000 http://www.ncbi.nlm.nih.gov/pubmed/10627386 Adjou Dormont hamsters Syrian wt 1 263K 0.01 50 i.c. i.p. small molecule MS-8209 25 mg/kg 6x/wk 25 21.4 202.7 30 survival 123.0 1.7 6 1 80.0 1.2 5 1 0.54 0.01 0 Adjou 1996 1996 http://www.ncbi.nlm.nih.gov/pubmed/8837228 Adjou Dormont mice C57BL/6 wt 1 BSE (mouse-passaged) 0.01 20 i.c. i.p. small molecule amphotericin b 2.5 mg/kg 6x/wk 2.5 2.1 12.2 0 56 survival 171.0 0.5 10 1 165.0 1.4 10 1 0.04 0.05 0 Adjou 1996 1996 http://www.ncbi.nlm.nih.gov/pubmed/8837228 Adjou Dormont mice C57BL/6 wt 1 BSE (mouse-passaged) 0.01 20 i.c. i.p. small molecule MS-8209 2.5 mg/kg 6x/wk 2.5 2.1 12.2 0 56 survival 167.0 1.3 10 1 165.0 1.4 10 1 0.01 1 0 Adjou 1996 1996 http://www.ncbi.nlm.nih.gov/pubmed/8837228 Adjou Dormont mice C57BL/6 wt 1 BSE (mouse-passaged) 0.01 20 i.c. i.p. small molecule MS-8209 10 mg/kg 6x/wk 10 8.6 48.6 0 56 survival 174.0 1.5 10 1 165.0 1.4 10 1 0.05 0.05 0 Adjou 1996 1996 http://www.ncbi.nlm.nih.gov/pubmed/8837228 Adjou Dormont mice C57BL/6 wt 1 BSE (mouse-passaged) 0.01 20 i.c. i.p. small molecule MS-8209 25 mg/kg 6x/wk 25 21.4 121.6 0 56 survival 170.0 1.5 10 1 165.0 1.4 10 1 0.03 0.05 0 Adjou 1996 1996 http://www.ncbi.nlm.nih.gov/pubmed/8837228 Adjou Dormont mice C57BL/6 wt 1 C506M3 0.01 20 i.c. i.p. small molecule amphotericin b 2.5 mg/kg 6x/wk 2.5 2.1 12.2 0 56 survival 186.0 1.8 10 1 169.0 1.2 10 1 0.10 0.001 0 Adjou 1996 1996 http://www.ncbi.nlm.nih.gov/pubmed/8837228 Adjou Dormont mice C57BL/6 wt 1 C506M3 0.01 20 i.c. i.p. small molecule MS-8209 2.5 mg/kg 6x/wk 2.5 2.1 12.2 0 56 survival 194.0 4.3 10 1 169.0 1.2 10 1 0.15 0.001 0 Wagner 2013 2013 http://www.ncbi.nlm.nih.gov/pubmed/23604588 http://link.springer.com/content/pdf/10.1007%2Fs00401-013-1114-9.pdf Wagner Giese mice C57BL/6 wt 1 RML 49 0.01 30 i.c. p.o. dmso and peanut butter dmso and peanut butter small molecule anle138b 10 mg/day 5 400.0 2270.3 0 survival 355.0 8 1 180.0 8 1 0.97 0.0001 0 Wagner 2013 2013 http://www.ncbi.nlm.nih.gov/pubmed/23604588 http://link.springer.com/content/pdf/10.1007%2Fs00401-013-1114-9.pdf Wagner Giese mice C57BL/6 wt 1 RML 49 0.01 30 i.c. p.o. dmso and peanut butter dmso and peanut butter small molecule anle138b 5 mg/day 5 200.0 1135.1 80 survival 242.0 8 1 168.0 8 1 0.44 0.0001 0 Wagner 2013 2013 http://www.ncbi.nlm.nih.gov/pubmed/23604588 http://link.springer.com/content/pdf/10.1007%2Fs00401-013-1114-9.pdf Wagner Giese mice C57BL/6 wt 1 RML 49 0.01 30 i.c. p.o. dmso and peanut butter dmso and peanut butter small molecule anle138b 5 mg/day 5 200.0 1135.1 120 survival 224.0 8 1 172.0 8 1 0.30 0.0001 0 Karapteyan & Sferrazza 2013 2013 http://www.ncbi.nlm.nih.gov/pubmed/23576755 Karapetyan & Sferrazza Lasmezas mice C57BL/6 wt 1 RML 56 0.01 20 i.c. i.p. 50% dmso 50% dmso small molecule tacrolimus 1.5 mg/kg/day 1.5 1.5 8.5 20 50 survival 149.0 7 1 149.0 2.0 5 1 0.00 1 1 "data not given, they merely state it's not significant" Karapteyan & Sferrazza 2013 2013 http://www.ncbi.nlm.nih.gov/pubmed/23576755 Karapetyan & Sferrazza Lasmezas mice C57BL/6 wt 1 RML 56 0.01 20 i.c. i.p. 50% dmso 50% dmso small molecule astemizole 3 mg/kg/day 3 3.0 17.0 20 50 survival 155.0 3.0 1 149.0 2.0 5 1 0.04 0.06 0 Mok 2006 2006 http://www.ncbi.nlm.nih.gov/pubmed/16890918 Mok Baier mice C57BL/6 wt 1 139A 0.001 20 i.c. p.o. food food small molecule simvastatin 100 mg/kg/day 100 100.0 567.6 100 survival 194.0 6.0 10 1 178.0 7.0 10 1 0.09 0.0003 0 Mok 2006 2006 http://www.ncbi.nlm.nih.gov/pubmed/16890918 Mok Baier mice C57BL/6 wt 1 139A 0.0001 20 i.c. p.o. food food small molecule simvastatin 100 mg/kg/day 100 100.0 567.6 100 survival 213.0 9.0 10 1 193.0 11.0 9 1 0.10 0.00003 0 Kempster 2007 2007 http://www.ncbi.nlm.nih.gov/pubmed/17496807 Kempster mice C57BL/6 wt 1 ME7 77 0.01 20 i.c. p.o. water water small molecule simvastatin 1 mg/kg/day 1 1.0 5.7 0 survival 193.0 1.1 8 1 183.0 2.2 8 1 0.05 0.05 0 Kempster 2007 2007 http://www.ncbi.nlm.nih.gov/pubmed/17496807 Kempster mice C57BL/6 wt 1 ME7 77 0.01 20 i.c. p.o. water water small molecule simvastatin 1 mg/kg/day 1 1.0 5.7 0 symptomatic 175.0 8 1 155.0 8 1 0.13 0 Kempster 2007 2007 http://www.ncbi.nlm.nih.gov/pubmed/17496807 Kempster mice C57BL/6 wt 1 ME7 77 0.01 20 i.c. p.o. water water small molecule simvastatin 1 mg/kg/day 1 1.0 5.7 123 survival 187.0 5.0 8 1 183.0 2.2 8 1 0.02 0.3 0 Haviv 2008 2008 http://www.ncbi.nlm.nih.gov/pubmed/18541796 Haviv mice FVB/N wt 1 RML 0.01 30 i.c. p.o. water water small molecule simvastatin 2 escalating to 20 mg/kg/day 20 20.0 113.5 72 survival 166.7 2.2 16 1 148.4 3.9 24 1 0.12 0.001 0 "expts a,c,d - average is from a,b,c,d" Haviv 2008 2008 http://www.ncbi.nlm.nih.gov/pubmed/18541796 Haviv mice FVB/N wt 1 RML 0.01 30 i.c. p.o. water water small molecule simvastatin 2 escalating to 20 mg/kg/day 20 20.0 113.5 41 survival 166.7 2.2 4 1 148.4 3.9 24 1 0.12 0.001 0 "expt b - average is from a,b,c,d" Haviv 2008 2008 http://www.ncbi.nlm.nih.gov/pubmed/18541796 Haviv mice FVB/N wt 1 RML 0.01 30 i.c. p.o. water water small molecule simvastatin 2 mg/kg/day 2 2.0 11.4 72 survival 161.7 3.5 4 1 148.4 3.9 24 1 0.09 0 Haviv 2008 2008 http://www.ncbi.nlm.nih.gov/pubmed/18541796 Haviv mice FVB/N wt 1 RML 0.01 30 i.p. p.o. water water small molecule simvastatin 2 mg/kg/day 2 2.0 11.4 0 survival 243.0 11.2 10 1 226.4 34.3 10 1 0.07 0 Haviv 2008 2008 http://www.ncbi.nlm.nih.gov/pubmed/18541796 Haviv mice FVB/N wt 1 RML 0.01 30 i.p. p.o. water water small molecule simvastatin 20 mg/kg/day 20 20.0 113.5 0 survival 239.1 2.5 9 1 226.4 34.3 10 1 0.06 0 Vetrugno 2009 2009 http://www.ncbi.nlm.nih.gov/pubmed/19282428 Vetrugno mice C57BL/6 wt 1 139A 0.01 i.c. p.o. water water small molecule pravastatin 200 mg/kg/day 200 200.0 1135.1 0 survival 194.3 7.5 13 1 177.4 4.4 10 1 0.10 0.0001 0 Luigi 2008 2008 http://www.ncbi.nlm.nih.gov/pubmed/18365024/ http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2268013/ Luigi Salmona hamsters Syrian wt 1 263K 49 0.0001 100 i.m. i.m. saline none small molecule doxycycline 10 mg/kg one-time 0 0 survival 355.0 11 1 217.0 11 1 0.64 0.031 0 Luigi 2008 2008 http://www.ncbi.nlm.nih.gov/pubmed/18365024/ http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2268013/ Luigi Salmona hamsters Syrian wt 1 263K 49 0.0001 100 i.m. i.p. saline none small molecule doxycycline 10 mg/kg per two days 5.0 47.3 0 40 survival 312.0 11 1 250.0 11 1 0.25 0.032 0 Luigi 2008 2008 http://www.ncbi.nlm.nih.gov/pubmed/18365024/ http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2268013/ Luigi Salmona hamsters Syrian wt 1 263K 49 0.0001 100 i.m. i.p. saline none small molecule tetracycline 10 mg/kg per two days 5.0 47.3 0 40 survival 330.0 11 1 250.0 11 1 0.32 0.028 0 Luigi 2008 2008 http://www.ncbi.nlm.nih.gov/pubmed/18365024/ http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2268013/ Luigi Salmona hamsters Syrian wt 1 263K 49 0.0001 100 i.m. i.p. saline none small molecule minocycline 10 mg/kg per two days 5.0 47.3 0 40 survival 453.0 11 1 250.0 11 1 0.81 0.004 0 Luigi 2008 2008 http://www.ncbi.nlm.nih.gov/pubmed/18365024/ http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2268013/ Luigi Salmona hamsters Syrian wt 1 263K 49 0.0001 100 s.c. i.p. saline none small molecule doxycycline 10 mg/kg per two days 5.0 47.3 4 44 survival 823.0 11 1 611.0 11 1 0.35 0.004 0 Luigi 2008 2008 http://www.ncbi.nlm.nih.gov/pubmed/18365024/ http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2268013/ Luigi Salmona hamsters Syrian wt 1 263K 49 0.0001 20 i.c. i.c. liposomes none small molecule doxycycline 25 ug/20 uL one-time 30 30 survival 134.0 11 1 122.0 11 1 0.10 0.023 0 Luigi 2008 2008 http://www.ncbi.nlm.nih.gov/pubmed/18365024/ http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2268013/ Luigi Salmona hamsters Syrian wt 1 263K 49 0.0001 20 i.c. i.c. liposomes none small molecule doxycycline 25 ug/20 uL one-time 60 60 survival 140.5 11 1 130.0 11 1 0.08 0.037 0 Luigi 2008 2008 http://www.ncbi.nlm.nih.gov/pubmed/18365024/ http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2268013/ Luigi Salmona hamsters Syrian wt 1 263K 49 0.0001 20 i.c. i.c. liposomes none small molecule doxycycline 25 ug/20 uL one-time 60 60 survival 144.0 11 1 130.0 11 1 0.11 0.063 0 Riemer 2008 2008 http://www.ncbi.nlm.nih.gov/pubmed/18198391 http://vir.sgmjournals.org/content/89/2/594.long Riemer Baier mice C57BL/6 wt 1 139A 35 0.001 30 i.c. p.o. food food small molecule ibuprofen 100 mg/kg/day 100.0 567.6 100 survival 172.0 8.9 11 1 188.0 9.9 12 1 -0.09 0 Riemer 2008 2008 http://www.ncbi.nlm.nih.gov/pubmed/18198391 http://vir.sgmjournals.org/content/89/2/594.long Riemer Baier mice C57BL/6 wt 1 139A 35 0.001 30 i.c. p.o. food food small molecule dapsone 16.75 mg/kg/day 16.8 95.1 100 survival 189.0 11.4 9 1 188.0 9.9 12 1 0.01 1 0 Riemer 2008 2008 http://www.ncbi.nlm.nih.gov/pubmed/18198391 http://vir.sgmjournals.org/content/89/2/594.long Riemer Baier mice C57BL/6 wt 1 139A 35 0.001 30 i.c. p.o. food food small molecule minocycline 200 mg/kg/day 200.0 1135.1 100 survival 178.0 5.7 17 1 175.0 8.4 17 1 0.02 1 0 Riemer 2008 2008 http://www.ncbi.nlm.nih.gov/pubmed/18198391 http://vir.sgmjournals.org/content/89/2/594.long Riemer Baier mice C57BL/6 wt 1 139A 35 0.001 30 i.c. p.o. food food small molecule curcumin 500 mg/kg/day 500.0 2837.8 100 survival 174.0 9.0 17 1 174.0 8.6 16 1 0.00 1 0 Riemer 2008 2008 http://www.ncbi.nlm.nih.gov/pubmed/18198391 http://vir.sgmjournals.org/content/89/2/594.long Riemer Baier mice C57BL/6 wt 1 139A 35 0.001 30 i.c. p.o. food food small molecule memantine 30 mg/kg/day 30.0 170.3 100 survival 196.0 11.7 8 1 181.0 7.2 8 1 0.08 0.01 0 Riemer 2008 2008 http://www.ncbi.nlm.nih.gov/pubmed/18198391 http://vir.sgmjournals.org/content/89/2/594.long Riemer Baier mice C57BL/6 wt 1 139A 35 0.0001 30 i.c. p.o. food food small molecule ibuprofen 100 mg/kg/day 100.0 567.6 100 survival 191.0 17.3 12 1 196.0 10.1 13 1 -0.03 1 0 Riemer 2008 2008 http://www.ncbi.nlm.nih.gov/pubmed/18198391 http://vir.sgmjournals.org/content/89/2/594.long Riemer Baier mice C57BL/6 wt 1 139A 35 0.0001 30 i.c. p.o. food food small molecule curcumin 50 mg/kg/day 50.0 283.8 100 survival 208.0 8.4 12 1 196.0 10.1 13 1 0.06 0.01 0 Riemer 2008 2008 http://www.ncbi.nlm.nih.gov/pubmed/18198391 http://vir.sgmjournals.org/content/89/2/594.long Riemer Baier mice C57BL/6 wt 1 139A 35 0.0001 30 i.c. p.o. food food small molecule curcumin 500 mg/kg/day 500.0 2837.8 100 survival 192.0 9.7 14 1 192.0 9.2 16 1 0.00 1 0 Caughey 2003 2003 http://www.ncbi.nlm.nih.gov/pubmed/12692251/ http://www.ncbi.nlm.nih.gov/pmc/articles/PMC153975/ Caughey Baron hamsters wt 1 263K 0.01 50 i.c. p.o. food food small molecule curcumin .2% wt/wt -14 survival 85.3 4.0 1 82.6 3.9 1 0.03 1 0 Caughey 2003 2003 http://www.ncbi.nlm.nih.gov/pubmed/12692251/ http://www.ncbi.nlm.nih.gov/pmc/articles/PMC153975/ Caughey Baron hamsters wt 1 263K 0.01 50 i.c. p.o. food food small molecule curcumin .2% wt/wt 0 survival 84.1 4.3 1 82.6 3.9 1 0.02 1 0 Caughey 2003 2003 http://www.ncbi.nlm.nih.gov/pubmed/12692251/ http://www.ncbi.nlm.nih.gov/pmc/articles/PMC153975/ Caughey Baron hamsters wt 1 263K 0.01 50 i.c. p.o. food food small molecule curcumin .2% wt/wt 45 survival 83.5 4.1 1 82.6 3.9 1 0.01 1 0 Caughey 2003 2003 http://www.ncbi.nlm.nih.gov/pubmed/12692251/ http://www.ncbi.nlm.nih.gov/pmc/articles/PMC153975/ Caughey Baron hamsters wt 1 263K 0.01 50 i.c. p.o. food food small molecule curcumin 2% wt/wt 45 survival 85.4 4.7 1 82.6 3.9 1 0.03 1 0 Doh-Ura 2004 2004 http://www.ncbi.nlm.nih.gov/pubmed/15113880 http://www.ncbi.nlm.nih.gov/pmc/articles/PMC400350/ Doh-Ura Iwaki mice Tg7 Race 1995 http://www.ncbi.nlm.nih.gov/pubmed/7576660 http://www.ncbi.nlm.nih.gov/pubmed/10623745 hamster wt 4.5 263K 0.01 20 i.c. i.c. pbs water small molecule pentosan polysulfate 1ug/kg/day 0.0 0.0 10 38 survival 51.6 1 51.6 1.8 1 0.00 1 1 Doh-Ura 2004 2004 http://www.ncbi.nlm.nih.gov/pubmed/15113880 http://www.ncbi.nlm.nih.gov/pmc/articles/PMC400350/ Doh-Ura Iwaki mice Tg7 Race 1995 http://www.ncbi.nlm.nih.gov/pubmed/7576660 http://www.ncbi.nlm.nih.gov/pubmed/10623745 hamster wt 4.5 263K 0.01 20 i.c. i.c. pbs water small molecule pentosan polysulfate 11ug/kg/day 0.0 0.1 10 38 survival 60.0 1 51.6 1.8 1 0.16 1 1 Doh-Ura 2004 2004 http://www.ncbi.nlm.nih.gov/pubmed/15113880 http://www.ncbi.nlm.nih.gov/pmc/articles/PMC400350/ Doh-Ura Iwaki mice Tg7 Race 1995 http://www.ncbi.nlm.nih.gov/pubmed/7576660 http://www.ncbi.nlm.nih.gov/pubmed/10623745 hamster wt 4.5 263K 0.01 20 i.c. i.c. pbs water small molecule pentosan polysulfate 110ug/kg/day 0.1 0.6 10 38 survival 80.0 1 51.6 1.8 1 0.55 0.05 1 Doh-Ura 2004 2004 http://www.ncbi.nlm.nih.gov/pubmed/15113880 http://www.ncbi.nlm.nih.gov/pmc/articles/PMC400350/ Doh-Ura Iwaki mice Tg7 Race 1995 http://www.ncbi.nlm.nih.gov/pubmed/7576660 http://www.ncbi.nlm.nih.gov/pubmed/10623745 hamster wt 4.5 263K 0.01 20 i.c. i.c. pbs water small molecule pentosan polysulfate 460ug/kg/day 0.5 2.6 10 38 survival 123.0 1 51.6 1.8 1 1.38 0.05 0 Doh-Ura 2004 2004 http://www.ncbi.nlm.nih.gov/pubmed/15113880 http://www.ncbi.nlm.nih.gov/pmc/articles/PMC400350/ Doh-Ura Iwaki mice Tg7 Race 1995 http://www.ncbi.nlm.nih.gov/pubmed/7576660 http://www.ncbi.nlm.nih.gov/pubmed/10623745 hamster wt 4.5 263K 0.01 20 i.c. i.c. pbs water small molecule pentosan polysulfate 1ug/kg/day 0.0 0.0 35 63 survival 51.0 1 51.0 1.8 1 0.00 1 1 Doh-Ura 2004 2004 http://www.ncbi.nlm.nih.gov/pubmed/15113880 http://www.ncbi.nlm.nih.gov/pmc/articles/PMC400350/ Doh-Ura Iwaki mice Tg7 Race 1995 http://www.ncbi.nlm.nih.gov/pubmed/7576660 http://www.ncbi.nlm.nih.gov/pubmed/10623745 hamster wt 4.5 263K 0.01 20 i.c. i.c. pbs water small molecule pentosan polysulfate 11ug/kg/day 0.0 0.1 35 63 survival 51.0 1 51.0 1.8 1 0.00 1 1 Doh-Ura 2004 2004 http://www.ncbi.nlm.nih.gov/pubmed/15113880 http://www.ncbi.nlm.nih.gov/pmc/articles/PMC400350/ Doh-Ura Iwaki mice Tg7 Race 1995 http://www.ncbi.nlm.nih.gov/pubmed/7576660 http://www.ncbi.nlm.nih.gov/pubmed/10623745 hamster wt 4.5 263K 0.01 20 i.c. i.c. pbs water small molecule pentosan polysulfate 110ug/kg/day 0.1 0.6 35 63 survival 51.0 1 51.0 1.8 1 0.00 1 1 Doh-Ura 2004 2004 http://www.ncbi.nlm.nih.gov/pubmed/15113880 http://www.ncbi.nlm.nih.gov/pmc/articles/PMC400350/ Doh-Ura Iwaki mice Tg7 Race 1995 http://www.ncbi.nlm.nih.gov/pubmed/7576660 http://www.ncbi.nlm.nih.gov/pubmed/10623745 hamster wt 4.5 263K 0.01 20 i.c. i.c. pbs water small molecule pentosan polysulfate 460ug/kg/day 0.5 2.6 35 63 survival 87.0 1 51.0 1.8 1 0.71 0.05 0 Doh-Ura 2004 2004 http://www.ncbi.nlm.nih.gov/pubmed/15113880 http://www.ncbi.nlm.nih.gov/pmc/articles/PMC400350/ Doh-Ura Iwaki mice Tg7 Race 1995 http://www.ncbi.nlm.nih.gov/pubmed/7576660 http://www.ncbi.nlm.nih.gov/pubmed/10623745 hamster wt 4.5 263K 0.01 20 i.c. i.c. pbs water small molecule pentosan polysulfate 110ug/kg/day 0.1 0.6 42 70 survival 49.0 1 49.0 1 0.00 1 1 Doh-Ura 2004 2004 http://www.ncbi.nlm.nih.gov/pubmed/15113880 http://www.ncbi.nlm.nih.gov/pmc/articles/PMC400350/ Doh-Ura Iwaki mice Tg7 Race 1995 http://www.ncbi.nlm.nih.gov/pubmed/7576660 http://www.ncbi.nlm.nih.gov/pubmed/10623745 hamster wt 4.5 263K 0.01 20 i.c. i.c. pbs water small molecule pentosan polysulfate 230ug/kg/day 0.2 1.3 42 70 survival 63.0 1 49.0 1 0.29 0.05 0 Doh-Ura 2004 2004 http://www.ncbi.nlm.nih.gov/pubmed/15113880 http://www.ncbi.nlm.nih.gov/pmc/articles/PMC400350/ Doh-Ura Iwaki mice Tg7 Race 1995 http://www.ncbi.nlm.nih.gov/pubmed/7576660 http://www.ncbi.nlm.nih.gov/pubmed/10623745 hamster wt 4.5 263K 0.01 20 i.c. i.c. pbs water small molecule pentosan polysulfate 345ug/kg/day 0.3 2.0 42 70 survival 49.0 1 49.0 1 0.00 1 1 Doh-Ura 2004 2004 http://www.ncbi.nlm.nih.gov/pubmed/15113880 http://www.ncbi.nlm.nih.gov/pmc/articles/PMC400350/ Doh-Ura Iwaki mice Tg7 Race 1995 http://www.ncbi.nlm.nih.gov/pubmed/7576660 http://www.ncbi.nlm.nih.gov/pubmed/10623745 hamster wt 4.5 263K 0.01 20 i.c. i.c. pbs water small molecule pentosan polysulfate 460ug/kg/day 0.5 2.6 42 70 survival 49.0 1 49.0 1 0.00 1 1 Doh-Ura 2004 2004 http://www.ncbi.nlm.nih.gov/pubmed/15113880 http://www.ncbi.nlm.nih.gov/pmc/articles/PMC400350/ Doh-Ura Iwaki mice Tg7 Race 1995 http://www.ncbi.nlm.nih.gov/pubmed/7576660 http://www.ncbi.nlm.nih.gov/pubmed/10623745 hamster wt 4.5 263K 0.01 20 i.c. i.c. pbs water small molecule pentosan polysulfate 110ug/kg/day 0.1 0.6 7 35 survival 75.0 1 47.0 1 0.60 0.01 1 Doh-Ura 2004 2004 http://www.ncbi.nlm.nih.gov/pubmed/15113880 http://www.ncbi.nlm.nih.gov/pmc/articles/PMC400350/ Doh-Ura Iwaki mice Tg7 Race 1995 http://www.ncbi.nlm.nih.gov/pubmed/7576660 http://www.ncbi.nlm.nih.gov/pubmed/10623745 hamster wt 4.5 263K 0.01 20 i.c. i.c. pbs water small molecule pentosan polysulfate 110ug/kg/day 0.1 0.6 21 49 survival 65.0 1 47.0 1 0.38 0.01 1 Doh-Ura 2004 2004 http://www.ncbi.nlm.nih.gov/pubmed/15113880 http://www.ncbi.nlm.nih.gov/pmc/articles/PMC400350/ Doh-Ura Iwaki mice Tg7 Race 1995 http://www.ncbi.nlm.nih.gov/pubmed/7576660 http://www.ncbi.nlm.nih.gov/pubmed/10623745 hamster wt 4.5 263K 0.01 20 i.c. i.c. pbs water small molecule pentosan polysulfate 110ug/kg/day 0.1 0.6 35 63 survival 55.0 1 47.0 1 0.17 1 1 Doh-Ura 2004 2004 http://www.ncbi.nlm.nih.gov/pubmed/15113880 http://www.ncbi.nlm.nih.gov/pmc/articles/PMC400350/ Doh-Ura Iwaki mice Tg7 Race 1995 http://www.ncbi.nlm.nih.gov/pubmed/7576660 http://www.ncbi.nlm.nih.gov/pubmed/10623745 hamster wt 4.5 263K 0.01 20 i.c. i.c. pbs water small molecule pentosan polysulfate 110ug/kg/day 0.1 0.6 42 70 survival 47.0 1 47.0 1 0.00 1 1 Doh-Ura 2004 2004 http://www.ncbi.nlm.nih.gov/pubmed/15113880 http://www.ncbi.nlm.nih.gov/pmc/articles/PMC400350/ Doh-Ura Iwaki mice Tg7 Race 1995 http://www.ncbi.nlm.nih.gov/pubmed/7576660 http://www.ncbi.nlm.nih.gov/pubmed/10623745 hamster wt 4.5 263K 0.01 20 i.c. i.c. pbs water small molecule pentosan polysulfate 460ug/kg/day 0.5 2.6 7 35 survival 122.0 1 47.0 1 1.60 0.01 0 Doh-Ura 2004 2004 http://www.ncbi.nlm.nih.gov/pubmed/15113880 http://www.ncbi.nlm.nih.gov/pmc/articles/PMC400350/ Doh-Ura Iwaki mice Tg7 Race 1995 http://www.ncbi.nlm.nih.gov/pubmed/7576660 http://www.ncbi.nlm.nih.gov/pubmed/10623745 hamster wt 4.5 263K 0.01 20 i.c. i.c. pbs water small molecule pentosan polysulfate 460ug/kg/day 0.5 2.6 21 49 survival 97.0 1 47.0 1 1.06 0.01 0 Doh-Ura 2004 2004 http://www.ncbi.nlm.nih.gov/pubmed/15113880 http://www.ncbi.nlm.nih.gov/pmc/articles/PMC400350/ Doh-Ura Iwaki mice Tg7 Race 1995 http://www.ncbi.nlm.nih.gov/pubmed/7576660 http://www.ncbi.nlm.nih.gov/pubmed/10623745 hamster wt 4.5 263K 0.01 20 i.c. i.c. pbs water small molecule pentosan polysulfate 460ug/kg/day 0.5 2.6 35 63 survival 80.0 1 47.0 1 0.70 0.05 1 Doh-Ura 2004 2004 http://www.ncbi.nlm.nih.gov/pubmed/15113880 http://www.ncbi.nlm.nih.gov/pmc/articles/PMC400350/ Doh-Ura Iwaki mice Tg7 Race 1995 http://www.ncbi.nlm.nih.gov/pubmed/7576660 http://www.ncbi.nlm.nih.gov/pubmed/10623745 hamster wt 4.5 263K 0.01 20 i.c. i.c. pbs water small molecule pentosan polysulfate 460ug/kg/day 0.5 2.6 42 70 survival 47.0 1 47.0 1 0.00 1 1 Doh-Ura 2004 2004 http://www.ncbi.nlm.nih.gov/pubmed/15113880 http://www.ncbi.nlm.nih.gov/pmc/articles/PMC400350/ Doh-Ura Iwaki mice Tg7 Race 1995 http://www.ncbi.nlm.nih.gov/pubmed/7576660 http://www.ncbi.nlm.nih.gov/pubmed/10623745 hamster wt 4.5 263K 0.01 20 i.c. s.c. pbs water small molecule pentosan polysulfate 0.2 mg/kg/day 0.2 1.1 10 38 survival 52.1 2.1 4 1 51.0 1.8 4 1 0.02 0 Doh-Ura 2004 2004 http://www.ncbi.nlm.nih.gov/pubmed/15113880 http://www.ncbi.nlm.nih.gov/pmc/articles/PMC400350/ Doh-Ura Iwaki mice Tg7 Race 1995 http://www.ncbi.nlm.nih.gov/pubmed/7576660 http://www.ncbi.nlm.nih.gov/pubmed/10623745 hamster wt 4.5 263K 0.01 20 i.c. s.c. pbs water small molecule pentosan polysulfate 2 mg/kg/day 2.0 11.4 10 38 survival 53.1 1.6 5 1 51.0 1.8 4 1 0.04 0 Doh-Ura 2004 2004 http://www.ncbi.nlm.nih.gov/pubmed/15113880 http://www.ncbi.nlm.nih.gov/pmc/articles/PMC400350/ Doh-Ura Iwaki mice Tg7 Race 1995 http://www.ncbi.nlm.nih.gov/pubmed/7576660 http://www.ncbi.nlm.nih.gov/pubmed/10623745 hamster wt 4.5 263K 0.01 20 i.c. s.c. pbs water small molecule pentosan polysulfate 20 mg/kg/day 20.0 113.5 10 38 survival 23.8 16.5 5 1 51.0 1.8 4 1 -0.53 0 Doh-Ura 2004 2004 http://www.ncbi.nlm.nih.gov/pubmed/15113880 http://www.ncbi.nlm.nih.gov/pmc/articles/PMC400350/ Doh-Ura Iwaki mice Tg7 Race 1995 http://www.ncbi.nlm.nih.gov/pubmed/7576660 http://www.ncbi.nlm.nih.gov/pubmed/10623745 hamster wt 4.5 263K 0.01 20 i.c. s.c. pbs water small molecule pentosan polysulfate 0.2 mg/kg/day 0.2 1.1 35 63 survival 51.8 1.8 4 1 51.8 2.0 4 1 0.00 0 Doh-Ura 2004 2004 http://www.ncbi.nlm.nih.gov/pubmed/15113880 http://www.ncbi.nlm.nih.gov/pmc/articles/PMC400350/ Doh-Ura Iwaki mice Tg7 Race 1995 http://www.ncbi.nlm.nih.gov/pubmed/7576660 http://www.ncbi.nlm.nih.gov/pubmed/10623745 hamster wt 4.5 263K 0.01 20 i.c. s.c. pbs water small molecule pentosan polysulfate 2 mg/kg/day 2.0 11.4 35 63 survival 50.0 1.8 5 1 51.8 2.0 4 1 -0.03 0 Doh-Ura 2004 2004 http://www.ncbi.nlm.nih.gov/pubmed/15113880 http://www.ncbi.nlm.nih.gov/pmc/articles/PMC400350/ Doh-Ura Iwaki mice Tg7 Race 1995 http://www.ncbi.nlm.nih.gov/pubmed/7576660 http://www.ncbi.nlm.nih.gov/pubmed/10623745 hamster wt 4.5 263K 0.01 20 i.c. s.c. pbs water small molecule pentosan polysulfate 20 mg/kg/day 20.0 113.5 35 63 survival 40.4 3.1 5 1 51.8 2.0 4 1 -0.22 0 Doh-Ura 2004 2004 http://www.ncbi.nlm.nih.gov/pubmed/15113880 http://www.ncbi.nlm.nih.gov/pmc/articles/PMC400350/ Doh-Ura Iwaki mice Tg7 Race 1995 http://www.ncbi.nlm.nih.gov/pubmed/7576660 http://www.ncbi.nlm.nih.gov/pubmed/10623745 hamster wt 4.5 263K 0.01 20 i.c. i.c. water water small molecule amphotericin b 0.9ug/kg/day 0.0 0.0 10 38 survival 51.6 1 51.6 1.8 1 0.00 1 1 Doh-Ura 2004 2004 http://www.ncbi.nlm.nih.gov/pubmed/15113880 http://www.ncbi.nlm.nih.gov/pmc/articles/PMC400350/ Doh-Ura Iwaki mice Tg7 Race 1995 http://www.ncbi.nlm.nih.gov/pubmed/7576660 http://www.ncbi.nlm.nih.gov/pubmed/10623745 hamster wt 4.5 263K 0.01 20 i.c. i.c. water water small molecule amphotericin b 9ug/kg/day 0.0 0.1 10 38 survival 64.0 1 51.6 1.8 1 0.24 0.01 0 Doh-Ura 2004 2004 http://www.ncbi.nlm.nih.gov/pubmed/15113880 http://www.ncbi.nlm.nih.gov/pmc/articles/PMC400350/ Doh-Ura Iwaki mice Tg7 Race 1995 http://www.ncbi.nlm.nih.gov/pubmed/7576660 http://www.ncbi.nlm.nih.gov/pubmed/10623745 hamster wt 4.5 263K 0.01 20 i.c. i.c. water water small molecule amphotericin b 90ug/kg/day 0.1 0.5 10 38 survival 64.0 1 51.6 1.8 1 0.24 0.01 0 Doh-Ura 2004 2004 http://www.ncbi.nlm.nih.gov/pubmed/15113880 http://www.ncbi.nlm.nih.gov/pmc/articles/PMC400350/ Doh-Ura Iwaki mice Tg7 Race 1995 http://www.ncbi.nlm.nih.gov/pubmed/7576660 http://www.ncbi.nlm.nih.gov/pubmed/10623745 hamster wt 4.5 263K 0.01 20 i.c. i.c. water water small molecule amphotericin b 860ug/kg/day 0.9 4.9 10 38 survival 51.6 1 51.6 1.8 1 0.00 1 1 Doh-Ura 2004 2004 http://www.ncbi.nlm.nih.gov/pubmed/15113880 http://www.ncbi.nlm.nih.gov/pmc/articles/PMC400350/ Doh-Ura Iwaki mice Tg7 Race 1995 http://www.ncbi.nlm.nih.gov/pubmed/7576660 http://www.ncbi.nlm.nih.gov/pubmed/10623745 hamster wt 4.5 263K 0.01 20 i.c. i.c. water water small molecule amphotericin b 0.9ug/kg/day 0.0 0.0 35 63 survival 51.6 1 51.0 1.8 1 0.01 1 1 Doh-Ura 2004 2004 http://www.ncbi.nlm.nih.gov/pubmed/15113880 http://www.ncbi.nlm.nih.gov/pmc/articles/PMC400350/ Doh-Ura Iwaki mice Tg7 Race 1995 http://www.ncbi.nlm.nih.gov/pubmed/7576660 http://www.ncbi.nlm.nih.gov/pubmed/10623745 hamster wt 4.5 263K 0.01 20 i.c. i.c. water water small molecule amphotericin b 9ug/kg/day 0.0 0.1 35 63 survival 51.6 1 51.0 1.8 1 0.01 1 1 Doh-Ura 2004 2004 http://www.ncbi.nlm.nih.gov/pubmed/15113880 http://www.ncbi.nlm.nih.gov/pmc/articles/PMC400350/ Doh-Ura Iwaki mice Tg7 Race 1995 http://www.ncbi.nlm.nih.gov/pubmed/7576660 http://www.ncbi.nlm.nih.gov/pubmed/10623745 hamster wt 4.5 263K 0.01 20 i.c. i.c. water water small molecule amphotericin b 90ug/kg/day 0.1 0.5 35 63 survival 51.6 1 51.0 1.8 1 0.01 1 1 Doh-Ura 2004 2004 http://www.ncbi.nlm.nih.gov/pubmed/15113880 http://www.ncbi.nlm.nih.gov/pmc/articles/PMC400350/ Doh-Ura Iwaki mice Tg7 Race 1995 http://www.ncbi.nlm.nih.gov/pubmed/7576660 http://www.ncbi.nlm.nih.gov/pubmed/10623745 hamster wt 4.5 263K 0.01 20 i.c. i.c. water water small molecule amphotericin b 860ug/kg/day 0.9 4.9 35 63 survival 51.6 1 51.0 1.8 1 0.01 1 1 Doh-Ura 2004 2004 http://www.ncbi.nlm.nih.gov/pubmed/15113880 http://www.ncbi.nlm.nih.gov/pmc/articles/PMC400350/ Doh-Ura Iwaki mice Tg7 Race 1995 http://www.ncbi.nlm.nih.gov/pubmed/7576660 http://www.ncbi.nlm.nih.gov/pubmed/10623745 hamster wt 4.5 263K 0.01 20 i.c. i.c. pbs water small molecule quinacrine .7 nmol/kg/day 0.7 0.0 0.0 10 38 survival 51.6 1 51.6 1.8 1 0.00 1 1 Doh-Ura 2004 2004 http://www.ncbi.nlm.nih.gov/pubmed/15113880 http://www.ncbi.nlm.nih.gov/pmc/articles/PMC400350/ Doh-Ura Iwaki mice Tg7 Race 1995 http://www.ncbi.nlm.nih.gov/pubmed/7576660 http://www.ncbi.nlm.nih.gov/pubmed/10623745 hamster wt 4.5 263K 0.01 20 i.c. i.c. pbs water small molecule quinacrine 7 nmol/kg/day 7 0.0 0.0 10 38 survival 51.6 1 51.6 1.8 1 0.00 0.01 0 Doh-Ura 2004 2004 http://www.ncbi.nlm.nih.gov/pubmed/15113880 http://www.ncbi.nlm.nih.gov/pmc/articles/PMC400350/ Doh-Ura Iwaki mice Tg7 Race 1995 http://www.ncbi.nlm.nih.gov/pubmed/7576660 http://www.ncbi.nlm.nih.gov/pubmed/10623745 hamster wt 4.5 263K 0.01 20 i.c. i.c. pbs water small molecule quinacrine 60 nmol/kg/day 60 0.0 0.1 10 38 survival 51.6 1 51.6 1.8 1 0.00 0.01 0 Doh-Ura 2004 2004 http://www.ncbi.nlm.nih.gov/pubmed/15113880 http://www.ncbi.nlm.nih.gov/pmc/articles/PMC400350/ Doh-Ura Iwaki mice Tg7 Race 1995 http://www.ncbi.nlm.nih.gov/pubmed/7576660 http://www.ncbi.nlm.nih.gov/pubmed/10623745 hamster wt 4.5 263K 0.01 20 i.c. i.c. pbs water small molecule quinacrine 510 nmol/kg/day 510 0.2 1.2 10 38 survival 51.6 1 51.6 1.8 1 0.00 1 1 Doh-Ura 2004 2004 http://www.ncbi.nlm.nih.gov/pubmed/15113880 http://www.ncbi.nlm.nih.gov/pmc/articles/PMC400350/ Doh-Ura Iwaki mice Tg7 Race 1995 http://www.ncbi.nlm.nih.gov/pubmed/7576660 http://www.ncbi.nlm.nih.gov/pubmed/10623745 hamster wt 4.5 263K 0.01 20 i.c. i.c. pbs water small molecule quinacrine 5000 nmol/kg/day 5000 2.0 11.4 10 38 survival 51.6 1 51.6 1.8 1 0.00 1 1 Doh-Ura 2004 2004 http://www.ncbi.nlm.nih.gov/pubmed/15113880 http://www.ncbi.nlm.nih.gov/pmc/articles/PMC400350/ Doh-Ura Iwaki mice Tg7 Race 1995 http://www.ncbi.nlm.nih.gov/pubmed/7576660 http://www.ncbi.nlm.nih.gov/pubmed/10623745 hamster wt 4.5 263K 0.01 20 i.c. i.c. pbs water small molecule quinacrine 50000 nmol/kg/day 50000 20.0 113.5 10 38 survival 30.0 1 51.6 1.8 1 -0.42 1 Doh-Ura 2004 2004 http://www.ncbi.nlm.nih.gov/pubmed/15113880 http://www.ncbi.nlm.nih.gov/pmc/articles/PMC400350/ Doh-Ura Iwaki mice Tg7 Race 1995 http://www.ncbi.nlm.nih.gov/pubmed/7576660 http://www.ncbi.nlm.nih.gov/pubmed/10623745 hamster wt 4.5 263K 0.01 20 i.c. i.c. pbs water small molecule quinacrine .7 nmol/kg/day 0.7 0.0 0.0 35 63 survival 51.0 1 51.0 1.8 1 0.00 1 1 Doh-Ura 2004 2004 http://www.ncbi.nlm.nih.gov/pubmed/15113880 http://www.ncbi.nlm.nih.gov/pmc/articles/PMC400350/ Doh-Ura Iwaki mice Tg7 Race 1995 http://www.ncbi.nlm.nih.gov/pubmed/7576660 http://www.ncbi.nlm.nih.gov/pubmed/10623745 hamster wt 4.5 263K 0.01 20 i.c. i.c. pbs water small molecule quinacrine 7 nmol/kg/day 7 0.0 0.0 35 63 survival 51.0 1 51.0 1.8 1 0.00 1 1 Doh-Ura 2004 2004 http://www.ncbi.nlm.nih.gov/pubmed/15113880 http://www.ncbi.nlm.nih.gov/pmc/articles/PMC400350/ Doh-Ura Iwaki mice Tg7 Race 1995 http://www.ncbi.nlm.nih.gov/pubmed/7576660 http://www.ncbi.nlm.nih.gov/pubmed/10623745 hamster wt 4.5 263K 0.01 20 i.c. i.c. pbs water small molecule quinacrine 60 nmol/kg/day 60 0.0 0.1 35 63 survival 51.0 1 51.0 1.8 1 0.00 1 1 Doh-Ura 2004 2004 http://www.ncbi.nlm.nih.gov/pubmed/15113880 http://www.ncbi.nlm.nih.gov/pmc/articles/PMC400350/ Doh-Ura Iwaki mice Tg7 Race 1995 http://www.ncbi.nlm.nih.gov/pubmed/7576660 http://www.ncbi.nlm.nih.gov/pubmed/10623745 hamster wt 4.5 263K 0.01 20 i.c. i.c. pbs water small molecule quinacrine 510 nmol/kg/day 510 0.2 1.2 35 63 survival 51.0 1 51.0 1.8 1 0.00 1 1 Doh-Ura 2004 2004 http://www.ncbi.nlm.nih.gov/pubmed/15113880 http://www.ncbi.nlm.nih.gov/pmc/articles/PMC400350/ Doh-Ura Iwaki mice Tg7 Race 1995 http://www.ncbi.nlm.nih.gov/pubmed/7576660 http://www.ncbi.nlm.nih.gov/pubmed/10623745 hamster wt 4.5 263K 0.01 20 i.c. i.c. pbs water small molecule quinacrine 5000 nmol/kg/day 5000 2.0 11.4 35 63 survival 51.0 1 51.0 1.8 1 0.00 1 1 Doh-Ura 2004 2004 http://www.ncbi.nlm.nih.gov/pubmed/15113880 http://www.ncbi.nlm.nih.gov/pmc/articles/PMC400350/ Doh-Ura Iwaki mice Tg7 Race 1995 http://www.ncbi.nlm.nih.gov/pubmed/7576660 http://www.ncbi.nlm.nih.gov/pubmed/10623745 hamster wt 4.5 263K 0.01 20 i.c. i.c. pbs water small molecule quinacrine 50000 nmol/kg/day 50000 20.0 113.5 35 63 survival 51.0 1 51.0 1.8 1 0.00 1 1 Doh-Ura 2004 2004 http://www.ncbi.nlm.nih.gov/pubmed/15113880 http://www.ncbi.nlm.nih.gov/pmc/articles/PMC400350/ Doh-Ura Iwaki mice Tg20 Fischer 1996 wt 10 RML 0.01 20 i.c. i.c. pbs water small molecule pentosan polysulfate 230 ug/kg/day 0.2 1.3 14 42 survival 141.0 1 65.0 1 1.17 0 Doh-Ura 2004 2004 http://www.ncbi.nlm.nih.gov/pubmed/15113880 http://www.ncbi.nlm.nih.gov/pmc/articles/PMC400350/ Doh-Ura Iwaki mice Tg20 Fischer 1996 wt 10 RML 0.01 20 i.c. i.c. pbs water small molecule pentosan polysulfate 230 ug/kg/day 0.2 1.3 49 77 survival 95.0 1 65.0 1 0.46 0 Doh-Ura 2004 2004 http://www.ncbi.nlm.nih.gov/pubmed/15113880 http://www.ncbi.nlm.nih.gov/pmc/articles/PMC400350/ Doh-Ura Iwaki mice Tg20 Fischer 1996 wt 10 Fukuoka-1 0.01 20 i.c. i.c. pbs water small molecule pentosan polysulfate 230 ug/kg/day 0.2 1.3 14 42 survival 153.0 1 106.0 1 0.44 0 Doh-Ura 2004 2004 http://www.ncbi.nlm.nih.gov/pubmed/15113880 http://www.ncbi.nlm.nih.gov/pmc/articles/PMC400350/ Doh-Ura Iwaki mice Tg20 Fischer 1996 wt 10 Fukuoka-1 0.01 20 i.c. i.c. pbs water small molecule pentosan polysulfate 230 ug/kg/day 0.2 1.3 49 77 survival 133.0 1 106.0 1 0.25 0 Manuelidis 1998 1998 http://www.ncbi.nlm.nih.gov/pubmed/9708762 Manuelidis Zaitsev rats wt 1 SY 0.01 50 i.c. p.o. peanut butter peanut butter small molecule indomethacin 3 mg/kg/day 3.0 1 clinical signs 325.0 4 1 310.0 8 1 0.05 0.011 0 Manuelidis 1998 1998 http://www.ncbi.nlm.nih.gov/pubmed/9708762 Manuelidis Zaitsev rats wt 1 SY 0.01 50 i.c. p.o. peanut butter peanut butter small molecule indomethacin 3 mg/kg/day 3.0 1 survival 344.0 4 1 344.0 8 1 0.00 1 1 Manuelidis 1998 1998 http://www.ncbi.nlm.nih.gov/pubmed/9708762 Manuelidis Zaitsev rats wt 1 SY 0.01 50 i.c. p.o. peanut butter peanut butter small molecule dapsone 2 mg/kg/day 2.0 1 clinical signs 390.0 4 1 310.0 8 1 0.26 0.0001 0 Manuelidis 1998 1998 http://www.ncbi.nlm.nih.gov/pubmed/9708762 Manuelidis Zaitsev rats wt 1 SY 0.01 50 i.c. p.o. peanut butter peanut butter small molecule dapsone 2 mg/kg/day 2.0 1 survival 437.0 4 1 344.0 8 1 0.27 0.0001 0 Priola 2000 2000 http://www.ncbi.nlm.nih.gov/pubmed/10688802 Priola Caughey mice Tg7 Race 1995 hamster wt 4.5 263K i.p. i.p. dmso dmso small molecule DPG2-Fe3+ "3x/week for 4 weeks, dose not stated" 0 28 survival 119.0 35.4 12.5 8 1 81.6 5.1 18 1 0.46 0.0001 0 Priola 2000 2000 http://www.ncbi.nlm.nih.gov/pubmed/10688802 Priola Caughey mice Tg7 Race 1995 hamster wt 4.5 263K i.p. i.p. dmso dmso small molecule DPG2-Fe3+ "3x/week for 4 weeks, dose not stated" 28 56 survival 88.3 8.0 2.4 11 1 81.6 5.1 18 1 0.08 0.01 0 Priola 2000 2000 http://www.ncbi.nlm.nih.gov/pubmed/10688802 Priola Caughey mice Tg7 Race 1995 hamster wt 4.5 263K i.p. i.p. dmso dmso small molecule DPG2-Fe3+ "3x/week for 4 weeks, dose not stated" 56 84 survival 87.4 16.1 4.3 14 1 81.6 5.1 18 1 0.07 0.05 0 Priola 2000 2000 http://www.ncbi.nlm.nih.gov/pubmed/10688802 Priola Caughey mice Tg7 Race 1995 hamster wt 4.5 263K i.p. i.p. dmso dmso small molecule TMPP-Fe3+ "3x/week for 4 weeks, dose not stated" 0 28 survival 171.5 43.4 13.1 11 1 81.6 5.1 18 1 1.10 0.0001 0 Priola 2000 2000 http://www.ncbi.nlm.nih.gov/pubmed/10688802 Priola Caughey mice Tg7 Race 1995 hamster wt 4.5 263K i.p. i.p. dmso dmso small molecule TMPP-Fe3+ "3x/week for 4 weeks, dose not stated" 56 84 survival 84.0 24.0 7.6 10 1 81.6 5.1 18 1 0.03 0.68 0 Priola 2000 2000 http://www.ncbi.nlm.nih.gov/pubmed/10688802 Priola Caughey mice Tg7 Race 1995 hamster wt 4.5 263K i.p. i.p. dmso dmso small molecule PcTS "3x/week for 4 weeks, dose not stated" 0 0 survival 114.0 25.5 8.5 9 1 81.6 5.1 18 1 0.40 0.0001 0 Priola 2000 2000 http://www.ncbi.nlm.nih.gov/pubmed/10688802 Priola Caughey mice Tg7 Race 1995 hamster wt 4.5 263K i.p. i.p. dmso dmso small molecule PcTS "3x/week for 4 weeks, dose not stated" 0 28 survival 216.6 74.2 18.0 17 1 81.6 5.1 18 1 1.65 0.0001 0 Priola 2000 2000 http://www.ncbi.nlm.nih.gov/pubmed/10688802 Priola Caughey mice Tg7 Race 1995 hamster wt 4.5 263K i.p. i.p. dmso dmso small molecule PcTS "3x/week for 4 weeks, dose not stated" 28 56 survival 86.3 7.4 1.8 17 1 81.6 5.1 18 1 0.06 0.03 0 Priola 2000 2000 http://www.ncbi.nlm.nih.gov/pubmed/10688802 Priola Caughey mice Tg7 Race 1995 hamster wt 4.5 263K i.p. i.p. dmso dmso small molecule PcTS "3x/week for 4 weeks, dose not stated" 56 84 survival 75.1 2.8 0.8 12 1 81.6 5.1 18 1 -0.08 0.0003 0 Leidel 2011 2011 http://www.ncbi.nlm.nih.gov/pubmed/21746938 http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3186986/ Leidel Groschup mice C57BL/6 RML i.c. i.p. 100% dmso 100% dmso small molecule DPP-1 100 ug/day 5.0 28.4 90 110 survival 174.0 3.8 1 160.0 4.1 1 0.09 0.01 0 Leidel 2011 2011 http://www.ncbi.nlm.nih.gov/pubmed/21746938 http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3186986/ Leidel Groschup mice Tga20 Fischer 1996 wt 10 RML i.p. i.p. 70% dmso 70% dmso small molecule DPP-1 100 ug/day 5.0 28.4 90 146 survival 149.0 3.0 1 112.0 6.6 1 0.33 0.05 0 treatment start date is never stated; presumably same as 'primary efficiency test' which was 90dpi Leidel 2011 2011 http://www.ncbi.nlm.nih.gov/pubmed/21746938 http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3186986/ Leidel Groschup mice Tga20 Fischer 1996 wt 10 RML i.p. p.o. 0.9% NaCl 0.9% NaCl small molecule DPP-1 500 ug/day 25.0 141.9 14 survival 155.0 10.0 1 113.0 6.4 1 0.37 0.05 0 Leidel 2011 2011 http://www.ncbi.nlm.nih.gov/pubmed/21746938 http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3186986/ Leidel Groschup mice C57BL/6 RML i.p. p.o. 0.9% NaCl 0.9% NaCl small molecule DPP-1 500 ug/day 25.0 141.9 -14 survival 212.0 1.8 1 192.0 0.5 1 0.10 0.01 0 Geissen 2011 2011 http://www.ncbi.nlm.nih.gov/pubmed/21755599 Geissen Groschup mice C57/6 wt 1 RML 0.1 50 i.c. i.p. 100% dmso 100% dmso small molecule S9 5 mg/kg/day 5.0 28.4 90 110 survival 173.8 8.6 4.0 1 157.6 4.9 10 1 0.10 0.05 0 Geissen 2011 2011 http://www.ncbi.nlm.nih.gov/pubmed/21755599 Geissen Groschup mice C57/6 wt 1 RML 0.1 50 i.c. i.p. 100% dmso 100% dmso small molecule S14 5 mg/kg/day 5.0 28.4 90 110 survival 170.3 3.8 4.0 1 157.6 4.9 10 1 0.08 0.005 0 Eiden 2012 2012 http://www.ncbi.nlm.nih.gov/pubmed/22363300 http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3281244/ Eiden Groschup mice C57BL/6 wt 1 RML 0.01 30 i.c. p.o. water water small molecule Scutellaria lateriflora 30 g herbs / 1 L water -14 survival 184.0 26.7 6 1 147.0 3.1 6 1 0.25 0.01 0 Eiden 2012 2012 http://www.ncbi.nlm.nih.gov/pubmed/22363300 http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3281244/ Eiden Groschup mice C57BL/6 wt 1 RML 0.01 50 i.p. p.o. water water small molecule Scutellaria lateriflora 30 g herbs / 1 L water -14 survival 206.0 8.6 6 1 191.0 8.6 6 1 0.08 0.05 0 Chung 2011 2011 http://www.ncbi.nlm.nih.gov/pubmed/21931860 http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3172287/ Chung Wisniewski mice CD-1 wt 1 139A 60 0.01 100 i.p. i.p. pbs pbs small molecule styryl #23I 10 mg/kg/day 10.0 56.8 0 30 survival 202.0 25.0 1 170 25 1 0.19 0.0001 0 Chung 2011 2011 http://www.ncbi.nlm.nih.gov/pubmed/21931860 http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3172287/ Chung Wisniewski mice CD-1 wt 1 139A 60 0.01 100 i.p. i.p. pbs pbs small molecule styryl #59 10 mg/kg/day 10.0 56.8 0 30 survival 215.0 25.0 1 170 25 1 0.26 0.0001 0 Chung 2011 2011 http://www.ncbi.nlm.nih.gov/pubmed/21931860 http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3172287/ Chung Wisniewski mice CD-1 wt 1 139A 60 0.01 100 i.p. i.p. pbs pbs small molecule trimipramine 10 mg/kg/day 10.0 56.8 0 survival 210.0 25.0 1 170 25 1 0.24 0.0001 0 Chung 2011 2011 http://www.ncbi.nlm.nih.gov/pubmed/21931860 http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3172287/ Chung Wisniewski mice CD-1 wt 1 139A 60 0.01 100 i.p. i.p. pbs pbs small molecule fluphenazine 1 mg/kg/day 1.0 5.7 0 survival 205.0 25.0 1 170 25 1 0.21 0.0005 0 Kawsaski 2007 2007 http://www.ncbi.nlm.nih.gov/pubmed/17881452 http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2169081/ Kawasaki Doh-Ura mice Tga20 Fischer 1996 wt 10 RML 35 0.01 20 i.c. p.o. food food small molecule cpd-B .1% wt/wt in feed 150.0 851.4 0 survival 108.0 2.8 7.0 1 68.5 5.9 6 1 0.58 0.01 0 Kawsaski 2007 2007 http://www.ncbi.nlm.nih.gov/pubmed/17881452 http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2169081/ Kawasaki Doh-Ura mice Tga20 Fischer 1996 wt 10 RML 35 0.01 20 i.c. p.o. food food small molecule cpd-B .13% wt/wt in feed 225.0 1277.0 0 survival 120.5 10.7 6.0 1 68.5 5.9 6 1 0.76 0.01 0 Kawsaski 2007 2007 http://www.ncbi.nlm.nih.gov/pubmed/17881452 http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2169081/ Kawasaki Doh-Ura mice Tga20 Fischer 1996 wt 10 RML 35 0.01 20 i.c. p.o. food food small molecule cpd-B .2% wt/wt in feed 300.0 1702.7 0 survival 154.3 19.9 6.0 1 68.5 5.9 6 1 1.25 0.01 0 Kawsaski 2007 2007 http://www.ncbi.nlm.nih.gov/pubmed/17881452 http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2169081/ Kawasaki Doh-Ura mice Tga20 Fischer 1996 wt 10 RML 35 0.01 20 i.c. p.o. food food small molecule cpd-B .2% wt/wt in feed 300.0 1702.7 0 survival 174.5 7.6 6.0 1 63.0 1.8 10 1 1.77 0.01 0 Kawsaski 2007 2007 http://www.ncbi.nlm.nih.gov/pubmed/17881452 http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2169081/ Kawasaki Doh-Ura mice Tga20 Fischer 1996 wt 10 RML 35 0.01 20 i.c. p.o. food food small molecule cpd-B .2% wt/wt in feed 300.0 1702.7 35 survival 117.2 7.0 9.0 1 63.0 1.8 10 1 0.86 0.01 0 Kawsaski 2007 2007 http://www.ncbi.nlm.nih.gov/pubmed/17881452 http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2169081/ Kawasaki Doh-Ura mice Tga20 Fischer 1996 wt 10 RML 35 0.01 20 i.c. p.o. food food small molecule cpd-B .2% wt/wt in feed 300.0 1702.7 49 survival 88.7 17.3 11.0 1 63.0 1.8 10 1 0.41 0.01 0 Kawsaski 2007 2007 http://www.ncbi.nlm.nih.gov/pubmed/17881452 http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2169081/ Kawasaki Doh-Ura mice Tga20 Fischer 1996 wt 10 RML 35 0.01 20 i.c. p.o. food food small molecule cpd-B .2% wt/wt in feed 300.0 1702.7 0 14 survival 102.1 2.9 9.0 1 63.0 1.8 10 1 0.62 0.01 0 Kawsaski 2007 2007 http://www.ncbi.nlm.nih.gov/pubmed/17881452 http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2169081/ Kawasaki Doh-Ura mice Tga20 Fischer 1996 wt 10 RML 35 0.01 20 i.c. p.o. food food small molecule cpd-B .2% wt/wt in feed 300.0 1702.7 0 35 survival 120.2 5.2 9.0 1 63.0 1.8 10 1 0.91 0.01 0 Kawsaski 2007 2007 http://www.ncbi.nlm.nih.gov/pubmed/17881452 http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2169081/ Kawasaki Doh-Ura mice Tga20 Fischer 1996 wt 10 RML 35 0.01 20 i.c. p.o. food food small molecule cpd-B .2% wt/wt in feed 300.0 1702.7 0 70 survival 142.5 7.8 8.0 1 63.0 1.8 10 1 1.26 0.01 0 Kawsaski 2007 2007 http://www.ncbi.nlm.nih.gov/pubmed/17881452 http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2169081/ Kawasaki Doh-Ura mice Tga20 Fischer 1996 wt 10 22L 35 0.01 20 i.c. p.o. food food small molecule cpd-B .2% wt/wt in feed 300.0 1702.7 0 survival 126.3 10.3 6.0 1 96.3 5.9 6 1 0.31 0.01 0 Kawsaski 2007 2007 http://www.ncbi.nlm.nih.gov/pubmed/17881452 http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2169081/ Kawasaki Doh-Ura mice Tga20 Fischer 1996 wt 10 Fukuoka-1 35 0.01 20 i.c. p.o. food food small molecule cpd-B .2% wt/wt in feed 300.0 1702.7 0 survival 142.2 21.0 5.0 1 101.6 12.1 8 1 0.40 0.01 0 Kawsaski 2007 2007 http://www.ncbi.nlm.nih.gov/pubmed/17881452 http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2169081/ Kawasaki Doh-Ura mice Tg7 Race 1995 http://www.ncbi.nlm.nih.gov/pubmed/7576660 http://www.ncbi.nlm.nih.gov/pubmed/10623745 hamster wt 4.5 263K 35 0.01 20 i.c. p.o. food food small molecule cpd-B .2% wt/wt in feed 300.0 1702.7 0 survival 52.7 2.8 11.0 1 48.0 3.0 6 1 0.10 0.05 0 Kawsaski 2007 2007 http://www.ncbi.nlm.nih.gov/pubmed/17881452 http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2169081/ Kawasaki Doh-Ura mice ICR wt 1 RML 35 0.01 20 i.c. p.o. food food small molecule cpd-B .2% wt/wt in feed 300.0 1702.7 0 187 survival 270.0 13.0 1 154.2 18.4 14 1 0.75 0.01 1 "It appears mice were not tracked past ~270 dpi. 7 of 13 treated mice were still alive at 270 dpi, making it approximately the median." Kawsaski 2007 2007 http://www.ncbi.nlm.nih.gov/pubmed/17881452 http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2169081/ Kawasaki Doh-Ura hamsters Syrian wt 1 263K 35 0.01 40 i.c. p.o. food food small molecule cpd-B .2% wt/wt in feed 0 survival 107.0 2.5 6.0 1 97.4 6.9 7 1 0.10 0.05 0 Kocisko 2004 2004 http://www.ncbi.nlm.nih.gov/pubmed/15269390 http://vir.sgmjournals.org/content/85/8/2479.long Kocisko Caughey mice Tg7 Race 1995 hamster wt 4.5 263K 0.0001 50 i.c. i.p. small molecule amodiaquine 50 mg/kg MWF 21.4 121.6 14 49 survival 60.2 2.0 5 1 61.8 2.0 8 1 -0.03 1 Kocisko 2004 2004 http://www.ncbi.nlm.nih.gov/pubmed/15269390 http://vir.sgmjournals.org/content/85/8/2479.long Kocisko Caughey mice Tg7 Race 1995 hamster wt 4.5 263K 0.0001 50 i.c. i.p. small molecule thioridazine 5 mg/kg MWF 2.1 12.2 14 49 survival 60.3 2.0 9 1 61.8 2.0 8 1 -0.02 1 Kocisko 2004 2004 http://www.ncbi.nlm.nih.gov/pubmed/15269390 http://vir.sgmjournals.org/content/85/8/2479.long Kocisko Caughey mice Tg7 Race 1995 hamster wt 4.5 263K 0.0001 50 i.c. i.p. small molecule thiothixene 5 mg/kg MWF 2.1 12.2 14 49 survival 60.2 2.0 12 1 61.8 2.0 8 1 -0.03 1 Kocisko 2004 2004 http://www.ncbi.nlm.nih.gov/pubmed/15269390 http://vir.sgmjournals.org/content/85/8/2479.long Kocisko Caughey mice Tg7 Race 1995 hamster wt 4.5 263K 0.0001 50 i.c. i.p. small molecule trifluoperazine 10 mg/kg MWF 4.3 24.3 14 49 survival 64.0 3.0 10 1 61.8 2.0 8 1 0.04 1 Kocisko 2004 2004 http://www.ncbi.nlm.nih.gov/pubmed/15269390 http://vir.sgmjournals.org/content/85/8/2479.long Kocisko Caughey mice Tg7 Race 1995 hamster wt 4.5 263K 0.00001 50 i.c. i.p. small molecule tetrandrine 50 mg/kg MWF 21.4 121.6 14 56 survival 67.8 6.0 6 1 66.4 3.0 12 1 0.02 1 Kocisko 2004 2004 http://www.ncbi.nlm.nih.gov/pubmed/15269390 http://vir.sgmjournals.org/content/85/8/2479.long Kocisko Caughey mice Tg7 Race 1995 hamster wt 4.5 263K 0.00001 50 i.c. p.o. water small molecule tannic acid 1500 mg/kg/day 1500.0 8513.5 14 56 survival 64.3 1.0 8 1 66.4 3.0 12 1 -0.03 1 Kocisko 2004 2004 http://www.ncbi.nlm.nih.gov/pubmed/15269390 http://vir.sgmjournals.org/content/85/8/2479.long Kocisko Caughey mice Tg7 Race 1995 hamster wt 4.5 263K 0.00001 50 i.c. p.o. water small molecule polyphenolic tea extract 1500 mg/kg/day 1500.0 8513.5 14 56 survival 70.0 7.0 6 1 66.4 3.0 12 1 0.05 1 Kocisko 2004 2004 http://www.ncbi.nlm.nih.gov/pubmed/15269390 http://vir.sgmjournals.org/content/85/8/2479.long Kocisko Caughey mice Tg7 Race 1995 hamster wt 4.5 263K 0.0001 50 i.c. i.p. small molecule amodiaquine 50 mg/kg MWF 21.4 121.6 14 56 survival 76.3 2.0 8 1 72.8 3.0 8 1 0.05 1 Kocisko 2004 2004 http://www.ncbi.nlm.nih.gov/pubmed/15269390 http://vir.sgmjournals.org/content/85/8/2479.long Kocisko Caughey mice Tg7 Race 1995 hamster wt 4.5 263K 0.0001 50 i.c. i.p. small molecule thioridazine 5 mg/kg MWF 2.1 12.2 14 56 survival 73.3 2.0 8 1 72.8 3.0 8 1 0.01 1 Kocisko 2004 2004 http://www.ncbi.nlm.nih.gov/pubmed/15269390 http://vir.sgmjournals.org/content/85/8/2479.long Kocisko Caughey mice Tg7 Race 1995 hamster wt 4.5 263K 0.0001 50 i.c. i.p. small molecule thiothixene 5 mg/kg MWF 2.1 12.2 14 56 survival 77.3 5.0 7 1 72.8 3.0 8 1 0.06 1 Kocisko 2004 2004 http://www.ncbi.nlm.nih.gov/pubmed/15269390 http://vir.sgmjournals.org/content/85/8/2479.long Kocisko Caughey mice Tg7 Race 1995 hamster wt 4.5 263K 0.0001 50 i.c. i.p. small molecule trifluoperazine 10 mg/kg MWF 4.3 24.3 14 56 survival 75.0 4.0 7 1 72.8 3.0 8 1 0.03 1 Kocisko 2004 2004 http://www.ncbi.nlm.nih.gov/pubmed/15269390 http://vir.sgmjournals.org/content/85/8/2479.long Kocisko Caughey mice Tg7 Race 1995 hamster wt 4.5 263K 0.01 50 i.p. p.o. water small molecule tannic acid 1500 mg/kg/day 1500.0 8513.5 -14 28 survival 88.5 6.9 8 1 95.5 14.7 8 1 -0.07 1 Kocisko 2004 2004 http://www.ncbi.nlm.nih.gov/pubmed/15269390 http://vir.sgmjournals.org/content/85/8/2479.long Kocisko Caughey mice Tg7 Race 1995 hamster wt 4.5 263K 0.01 50 i.p. p.o. water small molecule tannic acid 3000 mg/kg/day 3000.0 17027.0 -14 28 survival 90.5 7.1 6 1 95.5 14.7 8 1 -0.05 1 Kocisko 2004 2004 http://www.ncbi.nlm.nih.gov/pubmed/15269390 http://vir.sgmjournals.org/content/85/8/2479.long Kocisko Caughey mice Tg7 Race 1995 hamster wt 4.5 263K 0.01 50 i.p. p.o. water small molecule polyphenolic tea extract 1500 mg/kg/day 1500.0 8513.5 -14 28 survival 84.8 11.0 7 1 95.5 14.7 8 1 -0.11 1 Kocisko 2004 2004 http://www.ncbi.nlm.nih.gov/pubmed/15269390 http://vir.sgmjournals.org/content/85/8/2479.long Kocisko Caughey mice Tg7 Race 1995 hamster wt 4.5 263K 0.01 50 i.p. p.o. water small molecule polyphenolic grapeseed extract 2250 mg/kg/day 2250.0 12770.3 -14 28 survival 90.3 12.1 10 1 95.5 14.7 8 1 -0.05 1 Kocisko 2004 2004 http://www.ncbi.nlm.nih.gov/pubmed/15269390 http://vir.sgmjournals.org/content/85/8/2479.long Kocisko Caughey mice Tg7 Race 1995 hamster wt 4.5 263K 0.01 50 i.p. p.o. water small molecule polyphenolic pine bark extract 2250 mg/kg/day 2250.0 12770.3 -14 28 survival 85.8 7.9 10 1 95.5 14.7 8 1 -0.10 1 Kocisko 2004 2004 http://www.ncbi.nlm.nih.gov/pubmed/15269390 http://vir.sgmjournals.org/content/85/8/2479.long Kocisko Caughey mice Tg7 Race 1995 hamster wt 4.5 263K 0.01 50 i.p. i.p. small molecule trifluoperazine 10 mg/kg MWF 4.3 24.3 -14 28 survival 96.9 6.3 7 1 95.5 14.7 8 1 0.01 1 Ishikawa 2004 2004 http://www.ncbi.nlm.nih.gov/pubmed/15166464 http://vir.sgmjournals.org/content/85/6/1785.long Ishikawa Iwaki mice Tg7 Race 1995 hamster wt 4.5 263K 0.01 20 i.c. i.v. 10% dmso/saline 10% dmso/saline small molecule BSB 1 mg one-time dose 35 35 survival 57.4 1.9 5 1 55.8 1.3 5 1 0.03 1 Ishikawa 2004 2004 http://www.ncbi.nlm.nih.gov/pubmed/15166464 http://vir.sgmjournals.org/content/85/6/1785.long Ishikawa Iwaki mice Tga20 Fischer 1996 wt 6.5 RML 0.01 20 i.c. i.v. 10% dmso/saline 10% dmso/saline small molecule BSB 1 mg two-time dose at 45 and 60 dpi 45 60 survival 77.6 3.6 7 1 68.3 1.9 7 1 0.14 0.0001 Ishikawa 2006 2006 http://www.ncbi.nlm.nih.gov/pubmed/16987247 Ishikawa Doh-Ura mice Tg7 Race 1995 hamster wt 4.5 263K 0.01 20 i.c. i.v. 10% dmso 10% dmso small molecule BF-168 4 mg/kg once a week 0.6 3.2 14 42 survival 52.2 2.5 5 1 50.2 4.1 5 1 0.04 1 Ishikawa 2006 2006 http://www.ncbi.nlm.nih.gov/pubmed/16987247 Ishikawa Doh-Ura mice Tga20 Fischer 1996 wt 6.5 RML 0.01 20 i.c. i.v. 10% dmso 10% dmso small molecule BF-168 4 mg/kg once a week 0.6 3.2 28 56 survival 72.2 2.5 5 1 64.8 1.6 5 1 0.11 0.001 Ishikawa 2006 2006 http://www.ncbi.nlm.nih.gov/pubmed/16987247 Ishikawa Doh-Ura mice Tga20 Fischer 1996 wt 6.5 RML 0.01 20 i.c. s.c. 10% dmso 10% dmso small molecule BF-168 10 mg/kg/wk continuous infusion 1.4 8.1 28 56 survival 66.0 3.1 5 1 64.8 1.6 5 1 0.02 1 White 2008 2008 http://www.ncbi.nlm.nih.gov/pubmed/18632556 http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2474561/ White Mallucci mice Tg37+/+ Mallucci 2002 http://www.ncbi.nlm.nih.gov/pubmed/11823413/ wt 6 RML 7 i.c. i.c. pLL3.7 lentiviral vector LV-empty gene therapy LV-MW1 shRNA One-time hippocampal injection 56 56 survival 105.0 4.0 22 1 88.0 3.0 18 1 0.19 0.0000116 White 2003 2003 http://www.ncbi.nlm.nih.gov/pubmed/12621436 White Hawke mice FVB/N wt 1 RML 0.01 30 i.c. i.p. BRIC 126 antibody ICSM 35 2 mg injection twice weekly 28.6 162.2 7.0 survival 152.0 7.0 6 1 500 147.0 4.0 5 1 0.03 1 White 2003 2003 http://www.ncbi.nlm.nih.gov/pubmed/12621436 White Hawke mice FVB/N wt 1 RML 0.01 30 i.c. i.p. BRIC 126 antibody ICSM 35 2 mg injection twice weekly 28.6 162.2 132.5 survival 148.0 10.0 8 1 500 147.0 4.0 5 1 0.01 1 White 2003 2003 http://www.ncbi.nlm.nih.gov/pubmed/12621436 White Hawke mice FVB/N wt 1 RML 0.01 30 i.c. i.p. BRIC 126 antibody ICSM 18 2 mg injection twice weekly 28.6 162.2 7 survival 151.0 2.0 5 1 500 147.0 4.0 5 1 0.03 1 White 2003 2003 http://www.ncbi.nlm.nih.gov/pubmed/12621436 White Hawke mice FVB/N wt 1 RML 0.01 30 i.c. i.p. BRIC 126 antibody ICSM 18 2 mg injection twice weekly 28.6 162.2 132.5 survival 149.0 3.0 7 1 500 147.0 4.0 5 1 0.01 1 White 2003 2003 http://www.ncbi.nlm.nih.gov/pubmed/12621436 White Hawke mice FVB/N wt 1 RML 0.01 100 i.p. i.p. BRIC 126 antibody ICSM 35 2 mg injection twice weekly 28.6 162.2 7 survival 500.0 6 0 500 195.0 7.0 6 1 1.56 0.001 White 2003 2003 http://www.ncbi.nlm.nih.gov/pubmed/12621436 White Hawke mice FVB/N wt 1 RML 0.01 100 i.p. i.p. BRIC 126 antibody ICSM 35 2 mg injection twice weekly 28.6 162.2 30 survival 500.0 5 0 500 198.0 4.0 4 1 1.53 0.001 White 2003 2003 http://www.ncbi.nlm.nih.gov/pubmed/12621436 White Hawke mice FVB/N wt 1 RML 0.01 100 i.p. i.p. BRIC 126 antibody ICSM 35 2 mg injection twice weekly 28.6 162.2 172.5 survival 193.0 4.0 6 1 500 198.0 4.0 4 1 -0.03 1 White 2003 2003 http://www.ncbi.nlm.nih.gov/pubmed/12621436 White Hawke mice FVB/N wt 1 RML 0.01 100 i.p. i.p. BRIC 126 antibody ICSM 18 2 mg injection twice weekly 28.6 162.2 7 survival 500.0 6 0 500 195.0 7.0 6 1 1.56 0.001 White 2003 2003 http://www.ncbi.nlm.nih.gov/pubmed/12621436 White Hawke mice FVB/N wt 1 RML 0.01 100 i.p. i.p. BRIC 126 antibody ICSM 18 2 mg injection twice weekly 28.6 162.2 30 survival 500.0 5 0 500 198.0 4.0 4 1 1.53 0.001 White 2003 2003 http://www.ncbi.nlm.nih.gov/pubmed/12621436 White Hawke mice FVB/N wt 1 RML 0.01 100 i.p. i.p. BRIC 126 antibody ICSM 18 2 mg injection twice weekly 28.6 162.2 172.5 survival 193.0 5.0 5 1 500 198.0 4.0 4 1 -0.03 1 Goni 2008 2008 http://www.ncbi.nlm.nih.gov/pubmed/18407424/ http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2474749/ Goni Wisniewski mice CD-1 wt 1 139A 91 0.1 200 p.o. p.o. "S. typhimurium LVR01 carrying pTECH in .36M NAHCO3, pH 8.3 mixed 6:1 with alum" "S. typhimurium LVR01 carrying pTECH without PrP insert in .36M NAHCO3, pH 8.3 mixed 6:1 with alum" vaccination S. typhimurium LVR01 with 2xPrP "2x10^10 viable cells, via gavage 4 times plus 2 boosters with dead Salmonella" -49 -4 survival 269.9 50 0.64 400 194.0 10 1 0.39 1 Author stratified survival results by IgA and IgG response groups. Mean survival for whole group was calculated as (194*14+198*10+200*8+400*4+400*14) / 50 which does not take into account that 18/50 mice were censored at 400 dpi and never showed signs of illness. Goni 2005 2005 http://www.ncbi.nlm.nih.gov/pubmed/15878645 Goni Wisniewski mice CD-1 wt 1 139A 91 0.2 100 p.o. p.o. "S. typhimurium LVR01 carrying pTECH in .36M NAHCO3, pH 8.3 mixed 4:1 with aluma" "S. typhimurium LVR01 carrying pTECH without PrP insert in .36M NAHCO3, pH 8.3 mixed 4:1 with aluma" vaccination S. typhimurium LVR01 with 2xPrP "2x10^10 viable cells, via gavage 3 times" -49 -21 survival 300.0 20 0.7 500 185.0 20 1 0.62 0.0004 1 Author speaks of attack rate rather than mean/median survival. Treatment endpoint dpi is extremely approximate from Fig 2 Goni 2005 2005 http://www.ncbi.nlm.nih.gov/pubmed/15878645 Goni Wisniewski mice CD-1 wt 1 139A 91 0.2 100 p.o. p.o. "S. typhimurium LVR01 carrying pTECH in .36M NAHCO3, pH 8.3 mixed 4:1 with aluma" "S. typhimurium LVR01 carrying pTECH without PrP insert in .36M NAHCO3, pH 8.3 mixed 4:1 with aluma" vaccination S. typhimurium LVR01 with 1xPrP "2x10^10 viable cells, via gavage 3 times" -49 -21 survival 300.0 20 0.7 500 185.0 20 1 0.62 0.0015 1 Author speaks of attack rate rather than mean/median survival. Treatment endpoint dpi is extremely approximate from Fig 2 Kimberlin & Millson 1976 1976 http://www.ncbi.nlm.nih.gov/pubmed/820729 Kimberlin Millson mice albino wt 1 RML 0.1 i.p. p.o. food food small molecule cuprizone 0.05% in feed 42 98 survival 158.0 2.0 18 1 159.0 2.0 17 1 -0.01 1 Kimberlin & Millson 1976 1976 http://www.ncbi.nlm.nih.gov/pubmed/820729 Kimberlin Millson mice albino wt 1 RML 0.1 i.p. p.o. food food small molecule cuprizone 0.2% in feed 42 84 survival 157.0 2.0 18 1 159.0 2.0 17 1 -0.01 1 Kimberlin & Millson 1976 1976 http://www.ncbi.nlm.nih.gov/pubmed/820729 Kimberlin Millson mice albino wt 1 RML 0.1 i.p. p.o. food food small molecule cuprizone "7 days at 0.2%, 35 days at 0.3%, 14 days at 0.15%" 42 98 survival 179.0 2.0 13 1 171.0 1.0 18 1 0.05 0.01 Kimberlin & Millson 1976 1976 http://www.ncbi.nlm.nih.gov/pubmed/820729 Kimberlin Millson mice albino wt 1 RML 0.001 i.p. p.o. food food small molecule cuprizone "7 days at 0.2%, 35 days at 0.3%, 14 days at 0.15%" 42 98 survival 190.0 2.0 15 1 190.0 2.0 17 1 0.00 1 Kimberlin & Millson 1976 1976 http://www.ncbi.nlm.nih.gov/pubmed/820729 Kimberlin Millson mice albino wt 1 RML 0.00001 i.p. p.o. food food small molecule cuprizone "7 days at 0.2%, 35 days at 0.3%, 14 days at 0.15%" 42 98 survival 199.0 5.0 6 0.4 193.0 5.0 4 0.25 0.03 1 Meaning of attack rate is unclear - mice may have died of scrapie or of cuprizone toxicity Kimberlin & Millson 1976 1976 http://www.ncbi.nlm.nih.gov/pubmed/820729 Kimberlin Millson mice albino wt 1 RML 0.001 i.p. p.o. food food small molecule cuprizone 0.05% in feed -28 28 survival 192.0 1.0 15 1 191.0 2.0 17 1 0.01 Kimberlin & Millson 1976 1976 http://www.ncbi.nlm.nih.gov/pubmed/820729 Kimberlin Millson mice albino wt 1 RML 0.001 i.p. p.o. food food small molecule cuprizone 0.2% in feed -28 28 survival 201.0 3.0 8 1 191.0 2.0 17 1 0.05 0.001 Kimberlin & Millson 1976 1976 http://www.ncbi.nlm.nih.gov/pubmed/820729 Kimberlin Millson mice albino wt 1 RML 0.00001 i.p. p.o. food food small molecule cuprizone 0.05% in feed -28 28 survival 204.0 3.0 16 1 201.0 4.0 7 0.64 0.01 Meaning of attack rate is unclear - mice may have died of scrapie or of cuprizone toxicity Kimberlin & Millson 1976 1976 http://www.ncbi.nlm.nih.gov/pubmed/820729 Kimberlin Millson mice albino wt 1 RML 0.00001 i.p. p.o. food food small molecule cuprizone 0.2% in feed -28 28 survival 208.0 3.0 15 0.94 201.0 4.0 7 0.64 0.03 Meaning of attack rate is unclear - mice may have died of scrapie or of cuprizone toxicity Kimberlin & Millson 1976 1976 http://www.ncbi.nlm.nih.gov/pubmed/820729 Kimberlin Millson mice albino wt 1 RML 0.1 i.p. p.o. food food small molecule cuprizone "7 days at 0.2%, 35 days at 0.3%, 14 days at 0.15%" -28 28 survival 170.0 2.0 15 1 169.0 2.0 18 1 0.01 Kimberlin & Millson 1976 1976 http://www.ncbi.nlm.nih.gov/pubmed/820729 Kimberlin Millson mice albino wt 1 RML 0.001 i.p. p.o. food food small molecule cuprizone "7 days at 0.2%, 35 days at 0.3%, 14 days at 0.15%" -28 28 survival 190.0 3.0 16 1 187.0 2.0 17 1 0.02 Kimberlin & Millson 1976 1976 http://www.ncbi.nlm.nih.gov/pubmed/820729 Kimberlin Millson mice albino wt 1 RML 0.00001 i.p. p.o. food food small molecule cuprizone "7 days at 0.2%, 35 days at 0.3%, 14 days at 0.15%" -28 28 survival 207.0 0.0 13 0.87 206.0 0.0 2 0.12 0.00 Meaning of attack rate is unclear - mice may have died of scrapie or of cuprizone toxicity Kimberlin & Millson 1976 1976 http://www.ncbi.nlm.nih.gov/pubmed/820729 Kimberlin Millson mice albino wt 1 RML 0.001 i.c. p.o. food food small molecule cuprizone "7 days at 0.2%, 35 days at 0.3%, 14 days at 0.15%" -28 28 survival 147.0 1.0 17 1 144.0 2.0 17 1 0.02 Kimberlin & Millson 1976 1976 http://www.ncbi.nlm.nih.gov/pubmed/820729 Kimberlin Millson mice albino wt 1 RML 0.00001 i.c. p.o. food food small molecule cuprizone "7 days at 0.2%, 35 days at 0.3%, 14 days at 0.15%" -28 28 survival 166.0 2.0 18 1 162.0 1.0 18 1 0.02 Kimberlin & Millson 1976 1976 http://www.ncbi.nlm.nih.gov/pubmed/820729 Kimberlin Millson mice albino wt 1 RML 0.0000001 i.c. p.o. food food small molecule cuprizone "7 days at 0.2%, 35 days at 0.3%, 14 days at 0.15%" -28 28 survival 205.0 6.0 7 0.41 207.0 5.0 11 0.73 -0.01 Meaning of attack rate is unclear - mice may have died of scrapie or of cuprizone toxicity Sigurdsson 2003 2003 http://www.ncbi.nlm.nih.gov/pubmed/14519758 http://www.jbc.org/content/278/47/46199.full.pdf Sigurdsson Wisniewski mice CD-1 wt 1 139A 75 0.1 i.p. i.p. water water small molecule D-penacillamine "100 mg/kg in 100uL water, 5x/week" 71.4 405.4 0 survival 153.0 2.0 10 1 146.0 3.0 10 1 0.05 0.1 Sigurdsson 2003 2003 http://www.ncbi.nlm.nih.gov/pubmed/14519758 http://www.jbc.org/content/278/47/46199.full.pdf Sigurdsson Wisniewski mice CD-1 wt 1 139A 75 0.001 i.p. i.p. water water small molecule D-penacillamine "100 mg/kg in 100uL water, 5x/week" 71.4 405.4 0 survival 179.0 3.0 10 1 165.0 4.0 10 1 0.08 0.002 Hijazi 2003 2003 http://www.ncbi.nlm.nih.gov/pubmed/14642846/ Hijazi Gabizon hamsters Syrian wt 1 scrapie 28 0.1 50 i.c. p.o. water water small molecule CuSO4 300 ppm 28 survival 108.0 6.0 5 1 92.0 4.0 5 1 0.17 Hijazi 2003 2003 http://www.ncbi.nlm.nih.gov/pubmed/14642846/ Hijazi Gabizon hamsters Syrian wt 1 scrapie 28 0.1 50 i.c. p.o. water water small molecule CuSO4 750 ppm 28 survival 105.0 8.0 5 1 92.0 4.0 5 1 0.14 Hijazi 2003 2003 http://www.ncbi.nlm.nih.gov/pubmed/14642846/ Hijazi Gabizon hamsters Syrian wt 1 scrapie 28 0.1 50 i.c. p.o. water water small molecule CuSO4 1000 ppm in pulses of 10 days every 30 days 28 survival 115.0 6.0 5 1 92.0 4.0 5 1 0.25 Mitteregger 2009 2009 http://www.ncbi.nlm.nih.gov/pubmed/19635464/ Mitteregger Kretzschmar mice C57BL/6J wt 1 RML 49 0.1 30 i.c. p.o. food food other Cu2+ poor diet 1 +- .5 ug/g copper in diet -54 survival 145.4 8 1 145.4 7.5 8 1 0.00 1 Mice were treated five days ante partum Mitteregger 2009 2009 http://www.ncbi.nlm.nih.gov/pubmed/19635464/ Mitteregger Kretzschmar mice C57BL/6J wt 1 RML 49 0.1 30 i.c. p.o. water water small molecule trientine 1.5 mg/mL in drinking water -54 survival 145.4 8 1 145.4 7.5 8 1 0.00 1 Mice were treated five days ante partum Mitteregger 2009 2009 http://www.ncbi.nlm.nih.gov/pubmed/19635464/ Mitteregger Kretzschmar mice C57BL/6J wt 1 RML 49 0.1 30 i.c. p.o. water water small molecule CuSO4 250 mg/L in drinking water -54 survival 151.7 5.4 8 1 145.4 7.5 8 1 0.04 0 Mice were treated five days ante partum Mitteregger 2009 2009 http://www.ncbi.nlm.nih.gov/pubmed/19635464/ Mitteregger Kretzschmar mice C57BL/6J wt 1 RML 49 0.1 30 i.c. p.o. food food other Mn2+ rich diet "2000 ug/g Mn2+, normal 12 ug/g Cu2+ in diet" -54 survival 149.4 10.3 8 1 145.4 7.5 8 1 0.03 0 Mice were treated five days ante partum Mitteregger 2009 2009 http://www.ncbi.nlm.nih.gov/pubmed/19635464/ Mitteregger Kretzschmar mice C57BL/6J wt 1 RML 49 0.1 100 i.p. p.o. food food other Cu2+ poor diet 1 +- .5 ug/g copper in diet -54 survival 178.5 6.2 8 1 195.8 8.0 8 1 -0.09 0 Mitteregger 2009 2009 http://www.ncbi.nlm.nih.gov/pubmed/19635464/ Mitteregger Kretzschmar mice C57BL/6J wt 1 RML 49 0.1 100 i.p. p.o. water water small molecule trientine 1.5 mg/mL in drinking water -54 survival 190.0 9.2 8 1 195.8 8.0 8 1 -0.03 0 Mitteregger 2009 2009 http://www.ncbi.nlm.nih.gov/pubmed/19635464/ Mitteregger Kretzschmar mice C57BL/6J wt 1 RML 49 0.1 100 i.p. p.o. water water small molecule CuSO4 250 mg/L in drinking water -54 survival 198.7 6.5 8 1 195.8 8.0 8 1 0.01 0 Mitteregger 2009 2009 http://www.ncbi.nlm.nih.gov/pubmed/19635464/ Mitteregger Kretzschmar mice C57BL/6J wt 1 RML 49 0.1 100 i.p. p.o. food food other Mn2+ rich diet "2000 ug/g Mn2+, normal 12 ug/g Cu2+ in diet" -54 survival 188.8 14.1 8 1 195.8 8.0 8 1 -0.04 0 Mitteregger 2009 2009 http://www.ncbi.nlm.nih.gov/pubmed/19635464/ Mitteregger Kretzschmar mice C57BL/6J wt 1 RML 49 0.1 30 i.c. p.o. food food other "Cu2+ rich, Mn2+ poor diet" 3 ug/g Mn2+ and 300 ug/g Cu2+ in diet -54 survival 159.3 6.6 8 1 151.8 5.8 8 1 0.05 0 Mitteregger 2009 2009 http://www.ncbi.nlm.nih.gov/pubmed/19635464/ Mitteregger Kretzschmar mice C57BL/6J wt 1 RML 49 0.1 30 i.c. p.o. food food other Mn2+ rich diet "2000 ug/g Mn2+, normal 12 ug/g Cu2+ in diet" -54 survival 155.0 8 1 151.8 5.8 8 1 0.02 1 Mitteregger 2009 2009 http://www.ncbi.nlm.nih.gov/pubmed/19635464/ Mitteregger Kretzschmar mice C57BL/6J wt 1 RML 49 0.1 30 i.c. p.o. food food other Cu2+ rich diet 300 ug/g copper in diet -54 survival 155.0 8 1 151.8 5.8 8 1 0.02 1 Mitteregger 2009 2009 http://www.ncbi.nlm.nih.gov/pubmed/19635464/ Mitteregger Kretzschmar mice C57BL/6J wt 1 RML 49 0.1 100 i.p. p.o. food food other "Cu2+ rich, Mn2+ poor diet" 3 ug/g Mn2+ and 300 ug/g Cu2+ in diet -54 survival 198.6 8 1 198.6 8.2 8 1 0.00 1 Mitteregger 2009 2009 http://www.ncbi.nlm.nih.gov/pubmed/19635464/ Mitteregger Kretzschmar mice C57BL/6J wt 1 RML 49 0.1 100 i.p. p.o. food food other Mn2+ rich diet "2000 ug/g Mn2+, normal 12 ug/g Cu2+ in diet" -54 survival 198.6 8 1 198.6 8.2 8 1 0.00 1 Mitteregger 2009 2009 http://www.ncbi.nlm.nih.gov/pubmed/19635464/ Mitteregger Kretzschmar mice C57BL/6J wt 1 RML 49 0.1 100 i.p. p.o. food food other Cu2+ rich diet 300 ug/g copper in diet -54 survival 208.4 1.8 8 1 198.6 8.2 8 1 0.05 0 Canello 2012 2012 http://www.ncbi.nlm.nih.gov/pubmed/22198568 Canello Gabizon mice TgMHu2ME199K Friedman-Levi 2011 http://www.ncbi.nlm.nih.gov/pubmed/22072968/ E200K 2 p.o. water water small molecule CuSO4 300 ppm in drinking water 90 165 symptomatic 133.0 161.0 -0.17 1 "Authors compared curves of disease severity scores, censoring at 23 wpi. Controls reached a mean score of ~1.5 by 23 wpi, and treated group had reached this score by ~19 wpi. Times to endpoints are not given in the paper." Heiseke 2009 2009 http://www.ncbi.nlm.nih.gov/pubmed/19183256 http://onlinelibrary.wiley.com/doi/10.1111/j.1471-4159.2009.05906.x/pdf Heiseke Schatzl mice wt 1 139A i.c. p.o. small molecule rapamycin 100 survival 183.1 10.8 7 1 170.6 7.9 7 1 0.07 0.05 0 Heiseke 2009 2009 http://www.ncbi.nlm.nih.gov/pubmed/19183256 http://onlinelibrary.wiley.com/doi/10.1111/j.1471-4159.2009.05906.x/pdf Heiseke Schatzl mice wt 1 139A i.c. p.o. small molecule lithium 100 survival 174.1 18.8 7 1 170.6 7.9 7 1 0.02 1 0 Yun 2007 2007 http://www.ncbi.nlm.nih.gov/pubmed/17849316 Yun Klein mice C57BL/6 wt 1 RML 49 0.01 100 i.p. i.c. small molecule imatinib mesylate 128 survival 204.0 6.0 4 1 200.0 5.0 5 1 0.02 1 0 Yun 2007 2007 http://www.ncbi.nlm.nih.gov/pubmed/17849316 Yun Klein mice C57BL/6 wt 1 RML 49 0.00001 100 i.p. i.c. small molecule imatinib mesylate 7 37 survival 263.0 9.0 246.0 13.0 0.07 0.0054 0 Song 2008 2008 http://www.ncbi.nlm.nih.gov/pubmed/18474571 http://vir.sgmjournals.org/content/89/6/1533.long Song Horiuchi mice ICR wt 1 Chandler 28 0.1 20 i.c. i.c. mAb P2-284 antibody mAb 31C6 "intraventricular infusion (antibody concentration 2 mg/ml, pumping rate 0.5 ul/h, duration 14 days, volume 200 ml)" 1.2 6.8 60 74 survival 161.0 8.3 6 1 150.7 10.2 7 1 0.07 0.05 0 Song 2008 2008 http://www.ncbi.nlm.nih.gov/pubmed/18474571 http://vir.sgmjournals.org/content/89/6/1533.long Song Horiuchi mice ICR wt 1 Chandler 28 0.1 20 i.c. i.c. mAb P2-284 antibody mAb 31C6 "intraventricular infusion (antibody concentration 2 mg/ml, pumping rate 0.5 ul/h, duration 14 days, volume 200 ml)" 1.2 6.8 90 104 survival 165.0 10.9 9 1 151.7 9.8 10 1 0.09 0.05 0 Song 2008 2008 http://www.ncbi.nlm.nih.gov/pubmed/18474571 http://vir.sgmjournals.org/content/89/6/1533.long Song Horiuchi mice ICR wt 1 Chandler 28 0.1 20 i.c. i.c. mAb P2-284 antibody mAb 31C6 "intraventricular infusion (antibody concentration 2 mg/ml, pumping rate 0.5 ul/h, duration 14 days, volume 200 ml)" 1.2 6.8 120 134 survival 164.9 9.3 8 1 152.9 7.4 7 1 0.08 0.05 0 Song 2008 2008 http://www.ncbi.nlm.nih.gov/pubmed/18474571 http://vir.sgmjournals.org/content/89/6/1533.long Song Horiuchi mice ICR wt 1 Obihiro 28 0.1 20 i.c. i.c. mAb P2-284 antibody mAb 31C6 "intraventricular infusion (antibody concentration 2 mg/ml, pumping rate 0.5 ul/h, duration 14 days, volume 200 ml)" 1.2 6.8 60 74 survival 163.5 8.1 10 1 153.4 9.0 8 1 0.07 0.05 0 Song 2008 2008 http://www.ncbi.nlm.nih.gov/pubmed/18474571 http://vir.sgmjournals.org/content/89/6/1533.long Song Horiuchi mice ICR wt 1 Obihiro 28 0.1 20 i.c. i.c. mAb P2-284 antibody mAb 31C6 "intraventricular infusion (antibody concentration 2 mg/ml, pumping rate 0.5 ul/h, duration 14 days, volume 200 ml)" 1.2 6.8 90 104 survival 153.3 3.5 7 1 152.8 4.3 6 1 0.00 1 0 Song 2008 2008 http://www.ncbi.nlm.nih.gov/pubmed/18474571 http://vir.sgmjournals.org/content/89/6/1533.long Song Horiuchi mice ICR wt 1 Obihiro 28 0.1 20 i.c. i.c. mAb P2-284 antibody mAb 31C6 "intraventricular infusion (antibody concentration 2 mg/ml, pumping rate 0.5 ul/h, duration 14 days, volume 200 ml)" 1.2 6.8 120 134 survival 157.4 7.0 8 1 154.4 9.4 8 1 0.02 1 0 Ohsawa 2013 2013 http://www.ncbi.nlm.nih.gov/pubmed/23409836 Ohsawa Horiuchi mice ICR wt 1 Chandler 42 0.1 20 i.c. i.v. PBS mAb P2-284 antibody mAb 31C6 Antibody solution (2 mg/ml in PBS) was injected into a tail vein (0.25 ml/mouse) every week from 120 dpi 3.6 20.3 120 survival 158.3 9.6 12 1 153.3 4.3 9 1 0.03 1 0 Aguib 2009 2009 http://www.ncbi.nlm.nih.gov/pubmed/19182537 http://www.landesbioscience.com/journals/autophagy/AguibAUTO5-3.pdf Aguib Ertmer mice C57BL/6 wt 1 139A 0.1 i.p. p.o. water disaccharide sucrose small molecule trehalose 4% solutions via the drinking water (ad libitum) 0 survival 0.00 1 0 Abdel-Haq 2009 2009 http://www.ncbi.nlm.nih.gov/pubmed/19458902 Abdel-Haq Pocchiari mice C57BL/6 wt 1 KFu 0.1 100 i.p. i.p. small molecule PcTS "10 mg/kg, 3x/week for 4 weeks" 4.3 24.3 0 28 survival 389.1 22.5 10 1 334.9 36.4 9 1 0.16 0.0047 0 Abdel-Haq 2009 2009 http://www.ncbi.nlm.nih.gov/pubmed/19458902 Abdel-Haq Pocchiari mice C57BL/6 wt 1 mvCJD 0.1 100 i.p. i.p. small molecule PcTS "10 mg/kg, 3x/week for 4 weeks" 4.3 24.3 0 28 survival 309.8 43.2 10 1 272.5 12.9 10 1 0.14 0.0332 0 Abdel-Haq 2009 2009 http://www.ncbi.nlm.nih.gov/pubmed/19458902 Abdel-Haq Pocchiari mice C57BL/6 wt 1 139A 0.1 100 i.p. i.p. small molecule PcTS "10 mg/kg, 3x/week for 4 weeks" 4.3 24.3 0 28 survival 232.3 13.9 14 1 207.3 11.1 13 1 0.12 0.0003 0 Abdel-Haq 2009 2009 http://www.ncbi.nlm.nih.gov/pubmed/19458902 Abdel-Haq Pocchiari hamsters Syrian wt 1 263K 0.1 100 i.p. i.p. small molecule PcTS "5 mg/kg, 3x/week for 4 weeks" 2.1 20.3 0 28 survival 160.0 39.0 9 1 128.4 16.4 10 1 0.25 0.026 0 Abdel-Haq 2009 2009 http://www.ncbi.nlm.nih.gov/pubmed/19458902 Abdel-Haq Pocchiari hamsters Syrian wt 1 263K 0.1 100 i.p. i.p. small molecule PcTS "10 mg/kg, 3x/week for 4 weeks" 4.3 40.5 0 28 survival 137.8 25.5 9 1 128.4 16.4 10 1 0.07 0.3682 0 One treated animal was censored but not included in this analysis. Adjou 2003 2003 http://www.ncbi.nlm.nih.gov/pubmed/12917481 http://vir.sgmjournals.org/content/84/9/2595.long Adjou Lasmezas hamsters Syrian wt 1 263K 66 0.02 100 i.p. i.p. 5% glucose small molecule HM2602 25 mg/kg 1x/wk 3.6 33.8 0 survival 196.0 4.0 6 1 172.0 2.0 6 1 0.14 0 Adjou 2003 2003 http://www.ncbi.nlm.nih.gov/pubmed/12917481 http://vir.sgmjournals.org/content/84/9/2595.long Adjou Lasmezas hamsters Syrian wt 1 263K 66 0.02 100 i.p. i.p. 5% glucose small molecule HM5004 25 mg/kg 1x/wk 3.6 33.8 0 survival 174.0 2.0 6 1 172.0 2.0 6 1 0.01 1 0 Mukherjee 2010 2010 http://www.ncbi.nlm.nih.gov/pubmed/20949081/ http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2951383/pdf/ppat.1001138.pdf Mukherjee Soto mice C57BL/6 wt 1 RML 100 i.p. i.p. "0.9% NaCl, 1.25% PEG40 Castor Oil and 2% ethanol" small molecule tacrolimus 5 mg/kg/day dissolved in 100 uL of vehicle solution 5.0 28.4 210 survival 245.0 2.8 10 1 236.2 2.2 10 1 0.04 0.039 1 Mukherjee 2010 2010 http://www.ncbi.nlm.nih.gov/pubmed/20949081/ http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2951383/pdf/ppat.1001138.pdf Mukherjee Soto mice C57BL/6 wt 1 RML 100 i.p. i.p. "0.9% NaCl, 1.25% PEG40 Castor Oil and 2% ethanol" small molecule rapamycin 5 mg/kg/day dissolved in 100 uL of vehicle solution 5.0 28.4 210 survival 230.9 0.9 4 1 236.2 2.2 10 1 -0.02 0.094 1 Nakagaki 2013 2013 http://www.ncbi.nlm.nih.gov/pubmed/23800841 http://www.landesbioscience.com/journals/autophagy/2012AUTO0540R3.pdf Nakagaki Atarashi mice CD-1 wt 1 Fukuoka-1 i.c. i.p. small molecule tacrolimus 0.1 mg/kg/day 0.1 0.6 20 survival 141.0 2.6 5 1 125.5 1.6 6 1 0.12 0.01 0 Nakagaki 2013 2013 http://www.ncbi.nlm.nih.gov/pubmed/23800841 http://www.landesbioscience.com/journals/autophagy/2012AUTO0540R3.pdf Nakagaki Atarashi mice CD-1 wt 1 Fukuoka-1 i.c. i.p. small molecule tacrolimus 0.1 mg/kg/day 0.1 0.6 60 survival 123.0 2.1 5 1 125.5 1.6 6 1 -0.02 1 0 Nakagaki 2013 2013 http://www.ncbi.nlm.nih.gov/pubmed/23800841 http://www.landesbioscience.com/journals/autophagy/2012AUTO0540R3.pdf Nakagaki Atarashi mice CD-1 wt 1 Fukuoka-1 i.c. i.p. small molecule tacrolimus 1.0 mg/kg/day 1.0 5.7 20 survival 139.0 2.0 10 1 125.5 1.6 6 1 0.11 0.001 0 Nakagaki 2013 2013 http://www.ncbi.nlm.nih.gov/pubmed/23800841 http://www.landesbioscience.com/journals/autophagy/2012AUTO0540R3.pdf Nakagaki Atarashi mice CD-1 wt 1 Fukuoka-1 i.c. i.p. small molecule tacrolimus 1.0 mg/kg/day 1.0 5.7 60 survival 128.0 2.1 5 1 125.5 1.6 6 1 0.02 1 0 Nakagaki 2013 2013 http://www.ncbi.nlm.nih.gov/pubmed/23800841 http://www.landesbioscience.com/journals/autophagy/2012AUTO0540R3.pdf Nakagaki Atarashi mice Tg(SHa Prnp) hamster wt 263K 28 i.c. i.p. small molecule tacrolimus 1.0 mg/kg/day 1.0 5.7 13 survival 60.4 6.3 5 1 49.0 2.1 4 1 0.23 0.01 0 Nakagaki 2013 2013 http://www.ncbi.nlm.nih.gov/pubmed/23800841 http://www.landesbioscience.com/journals/autophagy/2012AUTO0540R3.pdf Nakagaki Atarashi mice Tg(SHa Prnp) hamster wt 263K 28 i.c. i.p. small molecule tacrolimus 1.0 mg/kg/day 1.0 5.7 27 survival 53.5 6.0 4 1 49.0 2.1 4 1 0.09 0 Doh-Ura 2007 2007 http://www.ncbi.nlm.nih.gov/pubmed/17438058/ http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1891374/pdf/0917-06.pdf Doh-Ura Iha mice Tg7 Race 1995 http://www.ncbi.nlm.nih.gov/pubmed/7576660 http://www.ncbi.nlm.nih.gov/pubmed/10623745 hamster wt 4.5 263K 0.1 200 gavage p.o. food small molecule fucoidan 2.5% in feed powder -7 -1 survival 215.4 40.5 5 1 231.0 28.3 6 1 -0.07 1 0 Doh-Ura 2007 2007 http://www.ncbi.nlm.nih.gov/pubmed/17438058/ http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1891374/pdf/0917-06.pdf Doh-Ura Iha mice Tg7 Race 1995 http://www.ncbi.nlm.nih.gov/pubmed/7576660 http://www.ncbi.nlm.nih.gov/pubmed/10623745 hamster wt 4.5 263K 0.1 200 gavage p.o. food small molecule fucoidan 5% in feed powder -7 -1 survival 243.4 31.8 5 1 231.0 28.3 6 1 0.05 1 0 Doh-Ura 2007 2007 http://www.ncbi.nlm.nih.gov/pubmed/17438058/ http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1891374/pdf/0917-06.pdf Doh-Ura Iha mice Tg7 Race 1995 http://www.ncbi.nlm.nih.gov/pubmed/7576660 http://www.ncbi.nlm.nih.gov/pubmed/10623745 hamster wt 4.5 263K 0.1 200 gavage p.o. food small molecule fucoidan 10% in feed powder -7 -1 survival 212.2 37.7 5 1 231.0 28.3 6 1 -0.08 1 0 Doh-Ura 2007 2007 http://www.ncbi.nlm.nih.gov/pubmed/17438058/ http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1891374/pdf/0917-06.pdf Doh-Ura Iha mice Tg7 Race 1995 http://www.ncbi.nlm.nih.gov/pubmed/7576660 http://www.ncbi.nlm.nih.gov/pubmed/10623745 hamster wt 4.5 263K 0.1 200 gavage p.o. food small molecule fucoidan 2.5% in feed powder 1 7 survival 346.8 28.0 5 1 231.0 28.3 6 1 0.50 0.01 0 Doh-Ura 2007 2007 http://www.ncbi.nlm.nih.gov/pubmed/17438058/ http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1891374/pdf/0917-06.pdf Doh-Ura Iha mice Tg7 Race 1995 http://www.ncbi.nlm.nih.gov/pubmed/7576660 http://www.ncbi.nlm.nih.gov/pubmed/10623745 hamster wt 4.5 263K 0.1 200 gavage p.o. food small molecule fucoidan 5% in feed powder 1 7 survival 368.1 73.9 7 1 231.0 28.3 6 1 0.59 0.01 0 Doh-Ura 2007 2007 http://www.ncbi.nlm.nih.gov/pubmed/17438058/ http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1891374/pdf/0917-06.pdf Doh-Ura Iha mice Tg7 Race 1995 http://www.ncbi.nlm.nih.gov/pubmed/7576660 http://www.ncbi.nlm.nih.gov/pubmed/10623745 hamster wt 4.5 263K 0.1 200 gavage p.o. food small molecule fucoidan 10% in feed powder 1 7 survival 367.4 44.9 5 1 231.0 28.3 6 1 0.59 0.01 0 Brazier 2010 2010 http://www.ncbi.nlm.nih.gov/pubmed/20456001 http://onlinelibrary.wiley.com/doi/10.1111/j.1471-4159.2010.06771.x/pdf Brazier Collins mice Balb/c wt 1 M1000 21 30 2.00E+05 i.c. i.p. small molecule Na2CaCDTA treated ip twice weekly with 200 uL 0.2 M Na2CaCDTA 7 survival 142.0 8.5 7 1 147.0 4.5 6 1 -0.03 1 0 Brazier 2010 2010 http://www.ncbi.nlm.nih.gov/pubmed/20456001 http://onlinelibrary.wiley.com/doi/10.1111/j.1471-4159.2010.06771.x/pdf Brazier Collins mice Balb/c wt 1 M1000 21 30 2.00E+05 i.c. i.p. small molecule Na2CaCDTA treated ip twice weekly with 200 uL 0.2 M Na2CaCDTA 7 survival 143.0 4.7 7 1 147.0 4.5 6 1 -0.03 1 0 Brazier 2010 2010 http://www.ncbi.nlm.nih.gov/pubmed/20456001 http://onlinelibrary.wiley.com/doi/10.1111/j.1471-4159.2010.06771.x/pdf Brazier Collins mice Balb/c wt 1 M1000 21 30 2.00E+05 i.c. i.p. small molecule Na2CaCDTA treated ip four times weekly with 200 uL 0.2 M Na2CaCDTA 75 survival 142.0 7.4 7 1 147.0 4.5 6 1 -0.03 1 0 Brazier 2010 2010 http://www.ncbi.nlm.nih.gov/pubmed/20456001 http://onlinelibrary.wiley.com/doi/10.1111/j.1471-4159.2010.06771.x/pdf Brazier Collins mice Balb/c wt 1 M1000 21 30 2.00E+01 i.c. i.p. small molecule Na2CaCDTA treated ip thrice weekly with 200 uL 0.2 M Na2CaCDTA 7 survival 189.0 3.8 8 1 169.0 2.5 10 1 0.12 0 Iwamaru 2012 2012 http://www.ncbi.nlm.nih.gov/pubmed/22693582 http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3365075/ Iwamaru Kitani mice C57BL/6 wt 1 Fukuoka-1 0.1 20 i.c. i.p. 10% ethanol 10% ethanol small molecule brilliant blue G 3 times per week for 3 weeks and 2 times per week for 4 additional weeks with 500 µl of 100 mg/kg BBG 42.9 243.2 100 149 survival 163.3 5.0 7 1 161.9 5.5 7 1 0.01 1 reduces PrPC and possibly PrP mRNA in cell culture Chen 2008 2008 http://www.ncbi.nlm.nih.gov/pubmed/18799131 http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2735260/ Chen Guarente mice outbred (CD1 and 129/Sv) wt 1 RML 105 0.00001 30 3.5 logs i.c. environmental calorie restriction 30% CR diet provided daily (controls fed ad libitum) 0 survival 164.5 20 1 172.0 19 1 -0.04 0.012 0 "methods section implies, but does not state, that calorie restriction began at 0 dpi or earlier" Chen 2008 2008 http://www.ncbi.nlm.nih.gov/pubmed/18799131 http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2735260/ Chen Guarente mice outbred (CD1 and 129/Sv) SIRT1 KO wt 1 RML 105 0.00001 30 3.5 logs i.c. environmental calorie restriction 30% CR diet provided daily (controls fed ad libitum) 0 survival 167.0 14 1 182.0 11 1 -0.08 0.002 0 "methods section implies, but does not state, that calorie restriction began at 0 dpi or earlier" Chen 2008 2008 http://www.ncbi.nlm.nih.gov/pubmed/18799131 http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2735260/ Chen Guarente mice outbred (CD1 and 129/Sv) wt 1 RML 105 0.00001 30 3.5 logs i.c. environmental calorie restriction 30% CR diet provided daily (controls fed ad libitum) 0 symptomatic 165.0 1 155.0 1 0.06 1 "methods section implies, but does not state, that calorie restriction began at 0 dpi or earlier" Chen 2008 2008 http://www.ncbi.nlm.nih.gov/pubmed/18799131 http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2735260/ Chen Guarente mice outbred (CD1 and 129/Sv) SIRT1 KO wt 1 RML 105 0.00001 30 3.5 logs i.c. environmental calorie restriction 30% CR diet provided daily (controls fed ad libitum) 0 symptomatic 165.0 1 165.0 1 0.00 1 "methods section implies, but does not state, that calorie restriction began at 0 dpi or earlier" Furuya 2006 2006 http://www.ncbi.nlm.nih.gov/pubmed/16759805 Furuya Kaneko mice FVB/N Tg4053 Telling 1996 http://www.ncbi.nlm.nih.gov/pubmed/8698234 wt 8 Obihiro 0.1 5 * i.c. PBS PBS peptide rPrP-218K 7-day intracerebroventricular administration of rPrPQ218K via an indwelling catheter connected to implanted osmotic pump 30 37 survival 131.0 7 1 117.0 6 1 0.12 0.016 0 "infection route was by implantation of a collagen sheet covered in infected brain homogenate, considered a model of iCJD" Furuya 2006 2006 http://www.ncbi.nlm.nih.gov/pubmed/16759805 Furuya Kaneko mice FVB/N Tg4053 Telling 1996 http://www.ncbi.nlm.nih.gov/pubmed/8698234 wt 8 Obihiro 0.1 5 * i.c. PBS PBS peptide rPrP-218K 7-day intracerebroventricular administration of rPrPQ218K via an indwelling catheter connected to implanted osmotic pump 60 67 survival 113.0 9 1 117.0 6 1 -0.03 1 0 Collins 2002 2002 http://www.ncbi.nlm.nih.gov/pubmed/12325081 Collins Masters mice Balb/c F wt 1 mouse-adapted CJD 21 0.1 30 i.c. p.o. deionized water deionized water small molecule quinacrine 10mg/kg/day 10.0 56.8 5 survival 140.0 7.3 7 1 140.0 6.8 8 1 0.00 1 0 Collins 2002 2002 http://www.ncbi.nlm.nih.gov/pubmed/12325081 Collins Masters mice Balb/c F wt 1 mouse-adapted CJD 21 0.1 30 i.c. p.o. deionized water deionized water small molecule quinacrine 10mg/kg/day 10.0 56.8 65 survival 140.0 10.8 7 1 140.0 6.8 8 1 0.00 1 0 Hagiwara 2007 2007 http://www.ncbi.nlm.nih.gov/pubmed/17409533 https://www.jstage.jst.go.jp/article/bpb/30/4/30_4_835/_pdf Hagiwara mice C57BL/6J F wt 1 Obihiro-I 42 0.01 25 i.c. i.p. PBS PBS small molecule U18666A "10mg/kg every 4d for the first 4x, then weekly" 2.5 14.2 -7 survival 167.0 4 1 167.0 4 1 0.00 1 0 Hagiwara 2007 2007 http://www.ncbi.nlm.nih.gov/pubmed/17409533 https://www.jstage.jst.go.jp/article/bpb/30/4/30_4_835/_pdf Hagiwara mice C57BL/6J F wt 1 Obihiro-I 42 0.01 25 i.c. i.p. PBS PBS small molecule U18666A "10mg/kg every 4d for the first 4x, then weekly" 2.5 14.2 14 survival 174.0 4 1 167.0 4 1 0.04 1 0 Hagiwara 2007 2007 http://www.ncbi.nlm.nih.gov/pubmed/17409533 https://www.jstage.jst.go.jp/article/bpb/30/4/30_4_835/_pdf Hagiwara mice C57BL/6J F wt 1 Obihiro-I 42 0.01 25 i.c. i.p. PBS PBS small molecule U18666A "10mg/kg every 4d for the first 4x, then weekly" 2.5 14.2 91 survival 179.0 4 1 167.0 4 1 0.07 1 0 Hagiwara 2007 2007 http://www.ncbi.nlm.nih.gov/pubmed/17409533 https://www.jstage.jst.go.jp/article/bpb/30/4/30_4_835/_pdf Hagiwara mice C57BL/6J F wt 1 Obihiro-I 42 0.01 25 i.c. i.p. PBS PBS small molecule U18666A and AY-9944 "10mg/kg of U18666A and 12 mg/kg of AY-9944 every 4d for the first 4x, then weekly" 91 survival 175.0 4 1 167.0 4 1 0.05 1 0 Relano-Gines 2011 2011 http://www.ncbi.nlm.nih.gov/pubmed/21881119 http://jid.oxfordjournals.org/content/204/7/1038.full.pdf Relano-Gines Crozet mice C57BL/6 F wt 1 RML 0.01 20 i.c. i.c. PBS PBS cell therapy wtPrP fetal NSCs 10^5 cells collected after 10 passages in ?otation was grafted into the hippocampus and the lateral ventricle 100 symptomatic 132.7 0.6 3 1 119.2 1.6 5 1 0.11 0.03 0 Relano-Gines 2011 2011 http://www.ncbi.nlm.nih.gov/pubmed/21881119 http://jid.oxfordjournals.org/content/204/7/1038.full.pdf Relano-Gines Crozet mice C57BL/6 F wt 1 RML 0.01 20 i.c. i.c. PBS PBS cell therapy wtPrP fetal NSCs 10^5 cells collected after 10 passages in ?otation was grafted into the hippocampus and the lateral ventricle 100 survival 175.0 2.8 2 1 150.6 2.3 5 1 0.16 0.01 0 Relano-Gines 2011 2011 http://www.ncbi.nlm.nih.gov/pubmed/21881119 http://jid.oxfordjournals.org/content/204/7/1038.full.pdf Relano-Gines Crozet mice C57BL/6 F wt 1 RML 0.01 20 i.c. i.c. PBS PBS cell therapy koPrP fetal NSCs 10^5 cells collected after 10 passages in ?otation was grafted into the hippocampus and the lateral ventricle 100 symptomatic 144.4 2.9 5 1 119.2 1.6 5 1 0.21 0.01 0 Relano-Gines 2011 2011 http://www.ncbi.nlm.nih.gov/pubmed/21881119 http://jid.oxfordjournals.org/content/204/7/1038.full.pdf Relano-Gines Crozet mice C57BL/6 F wt 1 RML 0.01 20 i.c. i.c. PBS PBS cell therapy koPrP fetal NSCs 10^5 cells collected after 10 passages in ?otation was grafted into the hippocampus and the lateral ventricle 100 survival 170.0 4 1 150.6 2.3 5 1 0.13 0 Relano-Gines 2011 2011 http://www.ncbi.nlm.nih.gov/pubmed/21881119 http://jid.oxfordjournals.org/content/204/7/1038.full.pdf Relano-Gines Crozet mice C57BL/6 F wt 1 RML 0.01 20 i.c. i.c. PBS PBS cell therapy poPrP fetal NSCs 10^5 cells collected after 10 passages in ?otation was grafted into the hippocampus and the lateral ventricle 100 symptomatic 145.3 2.9 4 1 119.2 1.6 5 1 0.22 0.03 0 Relano-Gines 2011 2011 http://www.ncbi.nlm.nih.gov/pubmed/21881119 http://jid.oxfordjournals.org/content/204/7/1038.full.pdf Relano-Gines Crozet mice C57BL/6 F wt 1 RML 0.01 20 i.c. i.c. PBS PBS cell therapy poPrP fetal NSCs 10^5 cells collected after 10 passages in ?otation was grafted into the hippocampus and the lateral ventricle 100 survival 170.0 3 1 150.6 2.3 5 1 0.13 0 Relano-Gines 2011 2011 http://www.ncbi.nlm.nih.gov/pubmed/21881119 http://jid.oxfordjournals.org/content/204/7/1038.full.pdf Relano-Gines Crozet mice C57BL/6 F wt 1 RML 0.01 20 i.c. i.c. PBS PBS cell therapy wtPrP fetal NSCs 10^5 cells collected after 10 passages in ?otation was grafted into the hippocampus and the lateral ventricle 120 symptomatic 111.0 0.0 4 1 103.5 5.7 4 1 0.07 1 0 Relano-Gines 2011 2011 http://www.ncbi.nlm.nih.gov/pubmed/21881119 http://jid.oxfordjournals.org/content/204/7/1038.full.pdf Relano-Gines Crozet mice C57BL/6 F wt 1 RML 0.01 20 i.c. i.c. PBS PBS cell therapy wtPrP fetal NSCs 10^5 cells collected after 10 passages in ?otation was grafted into the hippocampus and the lateral ventricle 120 survival 151.5 7.2 4 1 144.0 6.7 4 1 0.05 1 0 Relano-Gines 2011 2011 http://www.ncbi.nlm.nih.gov/pubmed/21881119 http://jid.oxfordjournals.org/content/204/7/1038.full.pdf Relano-Gines Crozet mice C57BL/6 F wt 1 RML 0.01 20 i.c. i.c. PBS PBS cell therapy koPrP fetal NSCs 10^5 cells collected after 10 passages in ?otation was grafted into the hippocampus and the lateral ventricle 120 symptomatic 110.0 4.6 4 1 103.5 5.7 4 1 0.06 1 0 Relano-Gines 2011 2011 http://www.ncbi.nlm.nih.gov/pubmed/21881119 http://jid.oxfordjournals.org/content/204/7/1038.full.pdf Relano-Gines Crozet mice C57BL/6 F wt 1 RML 0.01 20 i.c. i.c. PBS PBS cell therapy koPrP fetal NSCs 10^5 cells collected after 10 passages in ?otation was grafted into the hippocampus and the lateral ventricle 120 survival 148.0 10.1 4 1 144.0 6.7 4 1 0.03 1 0 Relano-Gines 2011 2011 http://www.ncbi.nlm.nih.gov/pubmed/21881119 http://jid.oxfordjournals.org/content/204/7/1038.full.pdf Relano-Gines Crozet mice C57BL/6 F wt 1 RML 0.01 20 i.c. i.c. PBS PBS cell therapy poPrP fetal NSCs 10^5 cells collected after 10 passages in ?otation was grafted into the hippocampus and the lateral ventricle 120 symptomatic 116.3 14.2 4 1 103.5 5.7 4 1 0.12 1 0 Relano-Gines 2011 2011 http://www.ncbi.nlm.nih.gov/pubmed/21881119 http://jid.oxfordjournals.org/content/204/7/1038.full.pdf Relano-Gines Crozet mice C57BL/6 F wt 1 RML 0.01 20 i.c. i.c. PBS PBS cell therapy poPrP fetal NSCs 10^5 cells collected after 10 passages in ?otation was grafted into the hippocampus and the lateral ventricle 120 survival 149.8 2.1 4 1 144.0 6.7 4 1 0.04 1 0 Kocisko 2006b 2006 http://www.ncbi.nlm.nih.gov/pubmed/17005828 http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1610090/ Kocisko Race mice Tg7 Race 1995 http://www.ncbi.nlm.nih.gov/pubmed/7576660 http://www.ncbi.nlm.nih.gov/pubmed/10623745 hamster wt 4.5 263K 0.01 50 i.c. i.c. small molecule FeTSP 50 uL at 0.5mM five times weekly 14 survival 61.9 12 1 45.0 12 1 0.38 1 Kocisko 2006b 2006 http://www.ncbi.nlm.nih.gov/pubmed/17005828 http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1610090/ Kocisko Race mice Tg7 Race 1995 http://www.ncbi.nlm.nih.gov/pubmed/7576660 http://www.ncbi.nlm.nih.gov/pubmed/10623745 hamster wt 4.5 263K 0.01 50 i.c. i.c. small molecule pentosan polysulfate 50 uL at 0.05mM five times weekly 14 survival 71.5 12 1 45.0 12 1 0.59 1 Kocisko 2006b 2006 http://www.ncbi.nlm.nih.gov/pubmed/17005828 http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1610090/ Kocisko Race mice Tg7 Race 1995 http://www.ncbi.nlm.nih.gov/pubmed/7576660 http://www.ncbi.nlm.nih.gov/pubmed/10623745 hamster wt 4.5 263K 0.01 50 i.c. i.c. small molecule FeTSP and pentosan polysulfate 50 uL at 0.5mM FsTSP and 0.05 mM PPS five times weekly 14 survival 97.4 12 1 45.0 12 1 1.16 1 Kocisko 2006b 2006 http://www.ncbi.nlm.nih.gov/pubmed/17005828 http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1610090/ Kocisko Race mice Tg7 Race 1995 http://www.ncbi.nlm.nih.gov/pubmed/7576660 http://www.ncbi.nlm.nih.gov/pubmed/10623745 hamster wt 4.5 263K 0.01 50 i.c. i.c. small molecule FeTSP 50 uL at 0.5mM five times weekly 28 survival 48.4 12 1 45.0 12 1 0.08 0.057 1 Kocisko 2006b 2006 http://www.ncbi.nlm.nih.gov/pubmed/17005828 http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1610090/ Kocisko Race mice Tg7 Race 1995 http://www.ncbi.nlm.nih.gov/pubmed/7576660 http://www.ncbi.nlm.nih.gov/pubmed/10623745 hamster wt 4.5 263K 0.01 50 i.c. i.c. small molecule pentosan polysulfate 50 uL at 0.05mM five times weekly 28 survival 57.4 12 1 45.0 12 1 0.28 1 Kocisko 2006b 2006 http://www.ncbi.nlm.nih.gov/pubmed/17005828 http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1610090/ Kocisko Race mice Tg7 Race 1995 http://www.ncbi.nlm.nih.gov/pubmed/7576660 http://www.ncbi.nlm.nih.gov/pubmed/10623745 hamster wt 4.5 263K 0.01 50 i.c. i.c. small molecule FeTSP and pentosan polysulfate 50 uL at 0.5mM FsTSP and 0.05 mM PPS five times weekly 28 survival 74.0 12 1 45.0 12 1 0.64 1 Kocisko 2006b 2006 http://www.ncbi.nlm.nih.gov/pubmed/17005828 http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1610090/ Kocisko Race mice Tg7 Race 1995 http://www.ncbi.nlm.nih.gov/pubmed/7576660 http://www.ncbi.nlm.nih.gov/pubmed/10623745 hamster wt 4.5 263K 0.01 50 i.c. i.c. small molecule FeTSP 50 uL at 0.5mM five times weekly 35 survival 45.0 12 1 45.0 12 1 0.00 1 1 Kocisko 2006b 2006 http://www.ncbi.nlm.nih.gov/pubmed/17005828 http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1610090/ Kocisko Race mice Tg7 Race 1995 http://www.ncbi.nlm.nih.gov/pubmed/7576660 http://www.ncbi.nlm.nih.gov/pubmed/10623745 hamster wt 4.5 263K 0.01 50 i.c. i.c. small molecule pentosan polysulfate 50 uL at 0.05mM five times weekly 35 survival 45.0 12 1 45.0 12 1 0.00 1 1 Kocisko 2006b 2006 http://www.ncbi.nlm.nih.gov/pubmed/17005828 http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1610090/ Kocisko Race mice Tg7 Race 1995 http://www.ncbi.nlm.nih.gov/pubmed/7576660 http://www.ncbi.nlm.nih.gov/pubmed/10623745 hamster wt 4.5 263K 0.01 50 i.c. i.c. small molecule FeTSP and pentosan polysulfate 50 uL at 0.5mM FsTSP and 0.05 mM PPS five times weekly 35 survival 45.0 12 1 45.0 12 1 0.00 1 1 Kocisko 2006b 2006 http://www.ncbi.nlm.nih.gov/pubmed/17005828 http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1610090/ Kocisko Race mice Tg7 Race 1995 http://www.ncbi.nlm.nih.gov/pubmed/7576660 http://www.ncbi.nlm.nih.gov/pubmed/10623745 hamster wt 4.5 263K 0.01 50 i.c. i.c. small molecule FeTSP and pentosan polysulfate "50 uL at 0.5mM FsTSP and 0.05 mM PPS, one-time i.c. dose plus PPS 10 mg/kg one-time i.p. dose." 45 survival 45.0 12 1 45.0 12 1 0.00 1 Kocisko 2006a 2006 http://www.ncbi.nlm.nih.gov/pubmed/16436739 http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1366918/ Kocisko Morrey mice Tg7 Race 1995 http://www.ncbi.nlm.nih.gov/pubmed/7576660 http://www.ncbi.nlm.nih.gov/pubmed/10623745 hamster wt 4.5 263K 0.01 50 i.p. i.p. small molecule FeTSP 12.5 mg/kg i.p. 3 doses/wk 5.4 30.4 -14 28 survival 161.5 27.3 8 1 90.0 6.4 9 1 0.79 0.0001 0 Kocisko 2006a 2006 http://www.ncbi.nlm.nih.gov/pubmed/16436739 http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1366918/ Kocisko Morrey mice Tg7 Race 1995 http://www.ncbi.nlm.nih.gov/pubmed/7576660 http://www.ncbi.nlm.nih.gov/pubmed/10623745 hamster wt 4.5 263K 0.01 50 i.p. i.p. small molecule TSP "25 mg/kg i.p. dosing on days -2, -1, and 0, then 3 doses/wk for 5 weeks" 10.7 60.8 -2 35 survival 132.0 13.9 8 1 90.0 6.4 9 1 0.47 0.0001 0 Kocisko 2006a 2006 http://www.ncbi.nlm.nih.gov/pubmed/16436739 http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1366918/ Kocisko Morrey mice Tg7 Race 1995 http://www.ncbi.nlm.nih.gov/pubmed/7576660 http://www.ncbi.nlm.nih.gov/pubmed/10623745 hamster wt 4.5 263K 0.01 50 i.p. i.p. small molecule FeTAP 12.5 mg/kg i.p. 3 doses/wk 5.4 30.4 -14 28 survival 437.5 160.0 6 1 90.0 6.4 9 1 3.86 0.0001 0 Kocisko 2006a 2006 http://www.ncbi.nlm.nih.gov/pubmed/16436739 http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1366918/ Kocisko Morrey mice Tg7 Race 1995 http://www.ncbi.nlm.nih.gov/pubmed/7576660 http://www.ncbi.nlm.nih.gov/pubmed/10623745 hamster wt 4.5 263K 0.01 50 i.p. i.p. small molecule TAP 6.25 mg/kg i.p. 3 doses/wk 2.7 15.2 -14 28 survival 166.0 43.3 8 1 90.0 6.4 9 1 0.84 0.0001 0 Kocisko 2006a 2006 http://www.ncbi.nlm.nih.gov/pubmed/16436739 http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1366918/ Kocisko Morrey mice Tg7 Race 1995 http://www.ncbi.nlm.nih.gov/pubmed/7576660 http://www.ncbi.nlm.nih.gov/pubmed/10623745 hamster wt 4.5 263K 0.01 50 i.c. i.c. small molecule FeTAP ".5 mM at days 14,16,18,21" 14 21 survival 54.4 5.4 8 1 46.1 1.2 8 1 0.18 0.001 0 Kocisko 2006a 2006 http://www.ncbi.nlm.nih.gov/pubmed/16436739 http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1366918/ Kocisko Morrey mice Tg7 Race 1995 http://www.ncbi.nlm.nih.gov/pubmed/7576660 http://www.ncbi.nlm.nih.gov/pubmed/10623745 hamster wt 4.5 263K 0.01 50 i.c. i.c. small molecule FeTAP ".5 mM at days 14, 21, 28, 35, 42" 14 42 survival 49.4 4.4 8 1 48.3 3.0 8 1 0.02 0 Kocisko 2006a 2006 http://www.ncbi.nlm.nih.gov/pubmed/16436739 http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1366918/ Kocisko Morrey mice Tg7 Race 1995 http://www.ncbi.nlm.nih.gov/pubmed/7576660 http://www.ncbi.nlm.nih.gov/pubmed/10623745 hamster wt 4.5 263K 0.01 50 i.c. i.c. small molecule NiTAP ".5 mM at days 13, 20, 27, 34, 41" 14 41 survival 50.1 7.2 7 1 48.7 6.8 8 1 0.03 0 Kocisko 2006a 2006 http://www.ncbi.nlm.nih.gov/pubmed/16436739 http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1366918/ Kocisko Morrey mice Tg7 Race 1995 http://www.ncbi.nlm.nih.gov/pubmed/7576660 http://www.ncbi.nlm.nih.gov/pubmed/10623745 hamster wt 4.5 263K 0.01 50 i.c. i.c. small molecule PdTAP ".25 mM at days 13, 20, 27, 34, 41" 14 41 survival 49.8 5.4 4 1 48.7 6.8 8 1 0.02 0 Kocisko 2006a 2006 http://www.ncbi.nlm.nih.gov/pubmed/16436739 http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1366918/ Kocisko Morrey mice Tg7 Race 1995 http://www.ncbi.nlm.nih.gov/pubmed/7576660 http://www.ncbi.nlm.nih.gov/pubmed/10623745 hamster wt 4.5 263K 0.01 50 i.c. i.c. small molecule ZnTAP ".1 mM at days 13, 20, 27, 34, 41" 14 41 survival 52.0 4.6 8 1 48.7 6.8 8 1 0.07 0 Kocisko 2006a 2006 http://www.ncbi.nlm.nih.gov/pubmed/16436739 http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1366918/ Kocisko Morrey mice Tg7 Race 1995 http://www.ncbi.nlm.nih.gov/pubmed/7576660 http://www.ncbi.nlm.nih.gov/pubmed/10623745 hamster wt 4.5 263K 0.01 50 i.c. i.c. small molecule TAP ".1 mM at days 13, 20, 27, 34, 41" 14 41 survival 49.7 4.1 9 1 48.7 6.8 8 1 0.02 0 Kocisko 2006a 2006 http://www.ncbi.nlm.nih.gov/pubmed/16436739 http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1366918/ Kocisko Morrey mice Tg7 Race 1995 http://www.ncbi.nlm.nih.gov/pubmed/7576660 http://www.ncbi.nlm.nih.gov/pubmed/10623745 hamster wt 4.5 263K 0.01 50 i.c. i.c. small molecule ZnTSP ".5 mM at days 13, 20, 27, 34, 41" 14 41 survival 52.8 5.2 10 1 48.7 6.8 8 1 0.08 0 Kocisko 2006a 2006 http://www.ncbi.nlm.nih.gov/pubmed/16436739 http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1366918/ Kocisko Morrey mice Tg7 Race 1995 http://www.ncbi.nlm.nih.gov/pubmed/7576660 http://www.ncbi.nlm.nih.gov/pubmed/10623745 hamster wt 4.5 263K 0.01 50 i.c. i.c. small molecule InTSP ".5 mM at days 13, 20, 27, 34, 41" 14 41 survival 53.7 5.8 9 1 48.7 6.8 8 1 0.10 0 Kocisko 2006a 2006 http://www.ncbi.nlm.nih.gov/pubmed/16436739 http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1366918/ Kocisko Morrey mice Tg7 Race 1995 http://www.ncbi.nlm.nih.gov/pubmed/7576660 http://www.ncbi.nlm.nih.gov/pubmed/10623745 hamster wt 4.5 263K 0.01 50 i.c. i.c. small molecule FeTSP ".5 mM at days 13, 20, 27, 34, 41" 14 41 survival 73.4 9.0 9 1 48.7 6.8 8 1 0.51 0.0001 0 Kocisko 2006a 2006 http://www.ncbi.nlm.nih.gov/pubmed/16436739 http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1366918/ Kocisko Morrey mice Tg7 Race 1995 http://www.ncbi.nlm.nih.gov/pubmed/7576660 http://www.ncbi.nlm.nih.gov/pubmed/10623745 hamster wt 4.5 263K 0.01 50 i.c. i.c. small molecule FeTSP ".5 mM at days 14, 21, 28, 35, 42, 49" 14 49 survival 70.9 8.6 7 1 50.6 3.0 8 1 0.40 0.0001 0 Kocisko 2006a 2006 http://www.ncbi.nlm.nih.gov/pubmed/16436739 http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1366918/ Kocisko Morrey mice Tg7 Race 1995 http://www.ncbi.nlm.nih.gov/pubmed/7576660 http://www.ncbi.nlm.nih.gov/pubmed/10623745 hamster wt 4.5 263K 0.01 50 i.c. i.c. small molecule FeTSP ".16 mM at days 14, 21, 28, 35, 42, 49" 14 49 survival 61.3 5.3 8 1 50.6 3.0 8 1 0.21 0.0001 0 Kocisko 2006a 2006 http://www.ncbi.nlm.nih.gov/pubmed/16436739 http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1366918/ Kocisko Morrey mice Tg7 Race 1995 http://www.ncbi.nlm.nih.gov/pubmed/7576660 http://www.ncbi.nlm.nih.gov/pubmed/10623745 hamster wt 4.5 263K 0.01 50 i.c. i.c. small molecule FeTSP ".05 mM at days 14, 21, 28, 35, 42, 49" 14 49 survival 59.8 5.1 8 1 50.6 3.0 8 1 0.18 0.0001 0 Kocisko 2006a 2006 http://www.ncbi.nlm.nih.gov/pubmed/16436739 http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1366918/ Kocisko Morrey mice Tg7 Race 1995 http://www.ncbi.nlm.nih.gov/pubmed/7576660 http://www.ncbi.nlm.nih.gov/pubmed/10623745 hamster wt 4.5 263K 0.01 50 i.c. i.c. small molecule pentosan polysulfate ".05 mM at days 14, 21, 28, 35, 42" 14 42 survival 72.3 3.9 8 1 48.3 3.0 8 1 0.50 0.0001 0 Bade 2006 2006 http://www.ncbi.nlm.nih.gov/pubmed/16455168 Bade Frey mice Balb/c wt 1 139A 0.1 100 p.o. i.n. vaccination rPrP90-231 + CT "100ug of PrP90-231 + 10ug of CT at post-priming days 0, 20, 34, 48, 62 where day 74 = 0 dpi" -74 -12 survival 266.0 1 257.5 1 0.03 0.05 0 Ishibashi 2007 2007 http://www.ncbi.nlm.nih.gov/pubmed/17055125 Ishibashi Sakaguchi mice Balb/c wt 1 Fukuoka-1 i.p. i.p. vaccination rMoPrP 100ug five times at 2-week intervals -63 -7 survival 269.0 22.0 7 1 291.0 10.0 8 1 -0.08 0.22 0 Ishibashi 2007 2007 http://www.ncbi.nlm.nih.gov/pubmed/17055125 Ishibashi Sakaguchi mice Balb/c wt 1 Fukuoka-1 i.p. i.p. vaccination rOvPrP 100ug five times at 2-week intervals -63 -7 survival 290.0 7 1 291.0 10.0 8 1 0.00 1 Ishibashi 2007 2007 http://www.ncbi.nlm.nih.gov/pubmed/17055125 Ishibashi Sakaguchi mice Balb/c wt 1 Fukuoka-1 i.p. i.p. vaccination rBoPrP 100ug five times at 2-week intervals -63 -7 survival 322.0 15.0 6 1 291.0 10.0 8 1 0.11 0.0008 0 Kocisko & Vaillant 2006 2006 http://www.ncbi.nlm.nih.gov/pubmed/16495266 http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1426446/ Kocisko Caughey mice Tg7 Race 1995 http://www.ncbi.nlm.nih.gov/pubmed/7576660 http://www.ncbi.nlm.nih.gov/pubmed/10623745 hamster wt 4.5 263K 0.1 50 i.p. s.c. 5% dextrose macromolecule phosphorothioated oligonucleotiude Randomer 1 "10 mg/kg 3 days before inoculation, then 3x/week for 4 weeks" 4.3 24.3 -3 25 survival 218.5 33.4 4 1 87.6 6.4 9 1 1.49 0.0001 0 Kocisko & Vaillant 2006 2006 http://www.ncbi.nlm.nih.gov/pubmed/16495266 http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1426446/ Kocisko Caughey mice Tg7 Race 1995 http://www.ncbi.nlm.nih.gov/pubmed/7576660 http://www.ncbi.nlm.nih.gov/pubmed/10623745 hamster wt 4.5 263K 0.1 50 i.p. s.c. 5% dextrose macromolecule phosphorothioated oligonucleotiude Randomer 1 "10 mg/kg 3 days before inoculation, then 3x/week for 10 weeks" 4.3 24.3 -3 67 survival 195.7 26.8 3 1 87.6 6.4 9 1 1.23 0.0001 0 Kocisko & Vaillant 2006 2006 http://www.ncbi.nlm.nih.gov/pubmed/16495266 http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1426446/ Kocisko Caughey mice Tg7 Race 1995 http://www.ncbi.nlm.nih.gov/pubmed/7576660 http://www.ncbi.nlm.nih.gov/pubmed/10623745 hamster wt 4.5 263K 0.1 50 i.p. i.p. 5% dextrose macromolecule phosphorothioated oligonucleotiude Randomer 1 "10 mg/kg 3 days before inoculation, then 3x/week for 4 weeks" 4.3 24.3 -3 25 survival 329.8 88.8 4 1 80.9 8.1 11 1 3.08 0.0001 0 Kocisko & Vaillant 2006 2006 http://www.ncbi.nlm.nih.gov/pubmed/16495266 http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1426446/ Kocisko Caughey mice Tg7 Race 1995 http://www.ncbi.nlm.nih.gov/pubmed/7576660 http://www.ncbi.nlm.nih.gov/pubmed/10623745 hamster wt 4.5 263K 0.1 50 i.p. i.p. 5% dextrose macromolecule phosphorothioated oligonucleotiude Randomer 1 "10 mg/kg 3 days before inoculation, then 3x/week for 10 weeks" 4.3 24.3 -3 67 survival 293.0 2 1 80.9 8.1 11 1 2.62 0.0001 0 Kocisko & Caughey 2006 2006 http://www.ncbi.nlm.nih.gov/pubmed/16379006 http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1346870/ Kocisko Caughey mice Tg7 Race 1995 http://www.ncbi.nlm.nih.gov/pubmed/7576660 http://www.ncbi.nlm.nih.gov/pubmed/10623745 hamster wt 4.5 263K 0.1 50 i.p. i.p. 10% DMSO in PBS small molecule mefloquine "5 mg/kg at days -2, -1, 0 and then 3x/wk for 4 weeks" 2.1 12.2 -2 28 survival 83.4 6.8 8 1 81.1 6.4 8 1 0.03 1 0 Bachy 2010 2010 http://www.ncbi.nlm.nih.gov/pubmed/19864503 http://vir.sgmjournals.org/content/91/3/809.long Bachy Carnaud mice wt 1 139A 0.005 100 i.p. i.p. PBS vaccination dendritic cells expressing PrP98-127 1x10^6 cells in each of a total of seven DC injections; the first three were at 15?day intervals and the remaining four were at monthly intervals -21 144 symptomatic 226.0 73.0 10 0.8 365 167.0 3.1 12 1 0.35 0.0005 0 mean and sd were re-calculated from raw data in table 1 http://vir.sgmjournals.org/content/91/3/809/T1.expansion.html Bachy 2010 2010 http://www.ncbi.nlm.nih.gov/pubmed/19864503 http://vir.sgmjournals.org/content/91/3/809.long Bachy Carnaud mice wt 1 139A 0.005 100 i.p. i.p. PBS vaccination dendritic cells expressing PrP98-127 1x10^6 cells in each of a total of seven DC injections; the first three were at 15?day intervals and the remaining four were at monthly intervals -21 144 survival 272.9 49.4 10 0.8 365 212.6 6.4 12 1 0.28 0.0005 0 mean and sd were re-calculated from raw data in table 1 http://vir.sgmjournals.org/content/91/3/809/T1.expansion.html Gourdain 2009 2009 http://www.ncbi.nlm.nih.gov/pubmed/19846876 http://www.jimmunol.org/content/183/10/6619.long Gourdain Carnaud mice RAG2-/- wt 1 139A 79 i.p. i.v. cell therapy primed boosted T lymphocytes 1e7 cells -30 -30 symptomatic 236.0 6 1 193.0 6 1 0.22 0.01 0 body text says 2e5 LD50 and figure 5 caption says 2e4 LD50. Gourdain 2009 2009 http://www.ncbi.nlm.nih.gov/pubmed/19846876 http://www.jimmunol.org/content/183/10/6619.long Gourdain Carnaud mice RAG2-/- wt 1 139A 79 i.p. i.v. cell therapy primed boosted T lymphocytes 1e7 cells -30 -30 survival 284.0 6 1 233.0 6 1 0.22 0.05 0 body text says 2e5 LD50 and figure 5 caption says 2e4 LD50. Gourdain 2009 2009 http://www.ncbi.nlm.nih.gov/pubmed/19846876 http://www.jimmunol.org/content/183/10/6619.long Gourdain Carnaud mice RAG2-/- wt 1 139A 79 i.p. i.v. cell therapy primed non-boosted T lymphocytes 1e7 cells -30 -30 symptomatic 193.0 6 1 193.0 6 1 0.00 1 1 body text says 2e5 LD50 and figure 5 caption says 2e4 LD50. Gourdain 2009 2009 http://www.ncbi.nlm.nih.gov/pubmed/19846876 http://www.jimmunol.org/content/183/10/6619.long Gourdain Carnaud mice RAG2-/- wt 1 139A 79 i.p. i.v. cell therapy primed non-boosted T lymphocytes 1e7 cells -30 -30 survival 235.0 6 1 233.0 6 1 0.01 1 1 body text says 2e5 LD50 and figure 5 caption says 2e4 LD50. Fujita 2011 2011 http://www.ncbi.nlm.nih.gov/pubmed/21516351 Fujita Sakaguchi mice C57BL/6 wt 1 Chandler 35 0.1 20 i.c. i.c. GFP-Ra2 microglial cells cell therapy microglia expressing anti-PrP scFv directly injected 3S9scFv/GFP-Ra2 microglial cells into the right cerebrum at 1 week and into the left cerebrum at 3 weeks before inoculation -21 -7 survival 175.0 10 1 168.0 10 1 0.04 0.014 1 Fujita 2011 2011 http://www.ncbi.nlm.nih.gov/pubmed/21516351 Fujita Sakaguchi mice C57BL/6 wt 1 Chandler 35 0.1 20 i.c. i.c. GFP-Ra2 microglial cells cell therapy microglia expressing anti-PrP scFv direct injection into right cerebrum 49 49 survival 165.0 165.0 0.00 1 1 Fujita 2011 2011 http://www.ncbi.nlm.nih.gov/pubmed/21516351 Fujita Sakaguchi mice C57BL/6 wt 1 Chandler 35 0.1 20 i.c. i.c. GFP-Ra2 microglial cells cell therapy microglia expressing anti-PrP scFv direct injection into right cerebrum 91 91 survival 165.0 165.0 0.00 1 1 Fujita 2011 2011 http://www.ncbi.nlm.nih.gov/pubmed/21516351 Fujita Sakaguchi mice C57BL/6 wt 1 22L 35 0.1 20 i.c. i.c. GFP-Ra2 microglial cells cell therapy microglia expressing anti-PrP scFv direct injection into right cerebrum 49 49 survival 162.0 158.0 0.03 0.035 1 Fujita 2011 2011 http://www.ncbi.nlm.nih.gov/pubmed/21516351 Fujita Sakaguchi mice C57BL/6 wt 1 22L 35 0.1 20 i.c. i.c. GFP-Ra2 microglial cells cell therapy microglia expressing anti-PrP scFv direct injection into right cerebrum 91 91 survival 158.0 158.0 0.00 1 1 Beringue 1999 1999 http://www.ncbi.nlm.nih.gov/pubmed/10423158 http://vir.sgmjournals.org/content/80/7/1873.full.pdf Beringue Dormont mice SCID wt 1 C506M3 56 0.002 100 i.p. i.p. NMG NMG small molecule MS-8209 25 mg/kg every day for two weeks 25.0 141.9 0 14 survival 312.0 10.0 35 0.142857143 500 320.0 7.0 36 0.444444444 -0.03 1 0 Attack rate is less than 100% because of LRS depletion in SCID mice. Beringue 1999 1999 http://www.ncbi.nlm.nih.gov/pubmed/10423158 http://vir.sgmjournals.org/content/80/7/1873.full.pdf Beringue Dormont mice R-SCID wt 1 C506M3 56 0.002 100 i.p. i.p. NMG NMG small molecule MS-8209 25 mg/kg every day for two weeks 25.0 141.9 0 14 survival 378.0 7.0 12 0.833333333 500 344.0 9.0 15 0.933333333 0.10 0.05 0 Rosset 2009 2009 http://www.ncbi.nlm.nih.gov/pubmed/19295917/ http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2654673/ Rosset Eloit mice C57BL/6 wt 1 139A 0.005 100 i.p. i.p. vaccination AdTA -35 -14 symptomatic 175.0 5.0 6 1 168.0 3.0 12 1 0.04 0.01 0 Rosset 2009 2009 http://www.ncbi.nlm.nih.gov/pubmed/19295917/ http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2654673/ Rosset Eloit mice C57BL/6 wt 1 139A 0.005 100 i.p. i.p. vaccination AdTA/AdhPrP -35 -14 symptomatic 177.0 6.0 12 1 168.0 3.0 12 1 0.05 0.0005 0 Rosset 2009 2009 http://www.ncbi.nlm.nih.gov/pubmed/19295917/ http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2654673/ Rosset Eloit mice C57BL/6 wt 1 139A 0.005 100 i.p. i.p. cell therapy B6 dendritic cells transduced with AdTA 5e5 DCs at weeks 0 and 3 -35 -14 symptomatic 179.0 10.0 6 0.833333333 300 168.0 3.0 12 1 0.07 0.049 0 Rosset 2009 2009 http://www.ncbi.nlm.nih.gov/pubmed/19295917/ http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2654673/ Rosset Eloit mice C57BL/6 wt 1 139A 0.005 100 i.p. i.p. cell therapy B6 dendritic cells transduced with AdTA/AdhPrP 5e5 DCs at weeks 0 and 3 -35 -14 symptomatic 183.0 3.0 6 1 168.0 3.0 12 1 0.09 0.0001 0 Rosset 2009 2009 http://www.ncbi.nlm.nih.gov/pubmed/19295917/ http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2654673/ Rosset Eloit mice C57BL/6 wt 1 139A 0.005 100 i.p. i.p. cell therapy Tg650 dendritic cells transduced with AdTA 5e5 DCs at weeks 0 and 3 -35 -14 symptomatic 201.0 7.0 5 0.8 300 168.0 3.0 12 1 0.20 0.0003 0 Rosset 2009 2009 http://www.ncbi.nlm.nih.gov/pubmed/19295917/ http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2654673/ Rosset Eloit mice C57BL/6 wt 1 139A 0.005 100 i.p. i.p. vaccination AdTA -35 -14 survival 222.0 3.0 6 1 209.0 8.0 12 1 0.06 0.025 0 Rosset 2009 2009 http://www.ncbi.nlm.nih.gov/pubmed/19295917/ http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2654673/ Rosset Eloit mice C57BL/6 wt 1 139A 0.005 100 i.p. i.p. vaccination AdTA/AdhPrP -35 -14 survival 231.0 9.0 12 1 209.0 8.0 12 1 0.11 0.0001 0 Rosset 2009 2009 http://www.ncbi.nlm.nih.gov/pubmed/19295917/ http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2654673/ Rosset Eloit mice C57BL/6 wt 1 139A 0.005 100 i.p. i.p. cell therapy B6 dendritic cells transduced with AdTA 5e5 DCs at weeks 0 and 3 -35 -14 survival 223.0 10.0 6 0.833333333 300 209.0 8.0 12 1 0.07 0.008 0 Rosset 2009 2009 http://www.ncbi.nlm.nih.gov/pubmed/19295917/ http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2654673/ Rosset Eloit mice C57BL/6 wt 1 139A 0.005 100 i.p. i.p. cell therapy B6 dendritic cells transduced with AdTA/AdhPrP 5e5 DCs at weeks 0 and 3 -35 -14 survival 225.0 12.0 6 1 209.0 8.0 12 1 0.08 0.023 0 Rosset 2009 2009 http://www.ncbi.nlm.nih.gov/pubmed/19295917/ http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2654673/ Rosset Eloit mice C57BL/6 wt 1 139A 0.005 100 i.p. i.p. cell therapy Tg650 dendritic cells transduced with AdTA 5e5 DCs at weeks 0 and 3 -35 -14 survival 246.0 16.0 5 0.8 300 209.0 8.0 12 1 0.18 0.001 0 Colombo 2009 2009 http://www.ncbi.nlm.nih.gov/pubmed/19685199 Colombo Forloni hamsters Syrian M wt 1 263K 63 0.001 50 i.p. i.p. small molecule ST1859 25mg/kg 3x/week for 3 weeks 10.7 101.4 1 22 survival 170.0 152.0 0.12 0.001 0 Colombo 2009 2009 http://www.ncbi.nlm.nih.gov/pubmed/19685199 Colombo Forloni hamsters Syrian M wt 1 263K 63 0.001 50 i.p. i.p. small molecule ST1745 "25mg/kg 3x/week for 2 weeks, then 10 mg/kg 3x/week for 1 week" 10.7 101.4 1 22 survival 170.0 152.0 0.12 0.001 0 Colombo 2009 2009 http://www.ncbi.nlm.nih.gov/pubmed/19685199 Colombo Forloni hamsters Syrian M wt 1 263K 63 0.00001 20 i.c. i.p. small molecule ST1859 25mg/kg 3x/week for 3 weeks 10.7 101.4 1 22 survival 123.0 119.0 0.03 1 0 Colombo 2009 2009 http://www.ncbi.nlm.nih.gov/pubmed/19685199 Colombo Forloni hamsters Syrian M wt 1 263K 63 0.00001 20 i.c. i.p. small molecule ST1745 "25mg/kg 3x/week for 2 weeks, then 10 mg/kg 3x/week for 1 week" 10.7 101.4 1 22 survival 129.0 119.0 0.08 0.03 0 Allen & Cochran 1977 1977 http://www.ncbi.nlm.nih.gov/pubmed/280156 http://deepblue.lib.umich.edu/bitstream/handle/2027.42/73540/j.1749-6632.1977.tb22003.x.pdf?sequence=1 Allen Cochran mice Swiss-Webster wt 1 Chandler 0.01 10e4.8 i.c. i.c. other Statolon 45 ug 24h before infection -1 -1 survival 149.5 20 158.2 20 -0.05 1 0 Allen & Cochran 1977 1977 http://www.ncbi.nlm.nih.gov/pubmed/280156 http://deepblue.lib.umich.edu/bitstream/handle/2027.42/73540/j.1749-6632.1977.tb22003.x.pdf?sequence=1 Allen Cochran mice Swiss-Webster wt 1 Chandler 0.01 10e4.8 i.c. i.c. other Sendai virus 1.5 HA units 24h before infection -1 -1 survival 144.8 20 162.1 20 -0.11 1 0 Allen & Cochran 1977 1977 http://www.ncbi.nlm.nih.gov/pubmed/280156 http://deepblue.lib.umich.edu/bitstream/handle/2027.42/73540/j.1749-6632.1977.tb22003.x.pdf?sequence=1 Allen Cochran mice Swiss-Webster wt 1 Chandler 0.01 10e4.8 i.c. i.c. other Poly(I:C) 0.3 ug 24h before infection -1 -1 survival 155.0 20 162.1 20 -0.04 1 0 Allen & Cochran 1977 1977 http://www.ncbi.nlm.nih.gov/pubmed/280156 http://deepblue.lib.umich.edu/bitstream/handle/2027.42/73540/j.1749-6632.1977.tb22003.x.pdf?sequence=1 Allen Cochran mice Swiss-Webster wt 1 Chandler 0.01 10e4.8 i.c. i.c. other Poly(I:C) 30 ug 24h before infection -1 -1 survival 154.8 20 162.1 20 -0.05 0.01 0 Allen & Cochran 1977 1977 http://www.ncbi.nlm.nih.gov/pubmed/280156 http://deepblue.lib.umich.edu/bitstream/handle/2027.42/73540/j.1749-6632.1977.tb22003.x.pdf?sequence=1 Allen Cochran mice Swiss-Webster wt 1 Chandler 0.01 10e4.8 i.c. i.c. other Statolon "45 ug starting 24h before infection, injected biweekly for 6 weeks following infection" -1 42 survival 128.3 20 146.8 20 -0.13 0.001 0 Text and figure disagree as to whether treatment was biweekly for 6 weeks or biweekly for 6 treatments total Allen & Cochran 1977 1977 http://www.ncbi.nlm.nih.gov/pubmed/280156 http://deepblue.lib.umich.edu/bitstream/handle/2027.42/73540/j.1749-6632.1977.tb22003.x.pdf?sequence=1 Allen Cochran mice Swiss-Webster wt 1 Chandler 0.01 10e4.8 i.c. i.c. other Sendai virus "1.5 HA unitsstarting 24h before infection, injected biweekly for 5 weeks following infection" -1 35 survival 131.9 20 153.6 20 -0.14 0.001 0 Text and figure disagree as to whether treatment was biweekly for 6 weeks or biweekly for 6 treatments total Allen & Cochran 1977 1977 http://www.ncbi.nlm.nih.gov/pubmed/280156 http://deepblue.lib.umich.edu/bitstream/handle/2027.42/73540/j.1749-6632.1977.tb22003.x.pdf?sequence=1 Allen Cochran mice Swiss-Webster wt 1 Chandler 0.01 10e4.8 i.c. i.c. other Poly(I:C) "0.3 ugstarting 24h before infection, injected weekly for 8 weeks following infection" -1 56 survival 153.0 20 150.3 20 0.02 1 0 Allen & Cochran 1977 1977 http://www.ncbi.nlm.nih.gov/pubmed/280156 http://deepblue.lib.umich.edu/bitstream/handle/2027.42/73540/j.1749-6632.1977.tb22003.x.pdf?sequence=1 Allen Cochran mice Swiss-Webster wt 1 Chandler 0.01 10e4.8 i.c. i.c. other Poly(I:C) "30 ug starting 24h before infection, injected weekly for 8 weeks following infection" -1 56 survival 136.8 20 150.3 20 -0.09 1 0 Fernandez-Borges 2006 2006 http://www.ncbi.nlm.nih.gov/pubmed/17005675 http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1617305/ Fernandez-Borges Rodriguez mice 129/Ola wt 1 BSE1 0.1 20 i.c. i.m. pCMV pCMV vaccination pCMV-PrP 100 ug DNA 3 times -70 -42 symptomatic 57.0 4 65.0 4 -0.12 0 Fernandez-Borges 2006 2006 http://www.ncbi.nlm.nih.gov/pubmed/17005675 http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1617305/ Fernandez-Borges Rodriguez mice 129/Ola wt 1 BSE1 0.1 20 i.c. i.m. pCMV pCMV vaccination pCMV-UbPrP 100 ug DNA 3 times -70 -42 symptomatic 82.0 4 65.0 4 0.26 0.001 0 Fernandez-Borges 2006 2006 http://www.ncbi.nlm.nih.gov/pubmed/17005675 http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1617305/ Fernandez-Borges Rodriguez mice 129/Ola wt 1 BSE1 0.1 20 i.c. i.m. pCMV pCMV vaccination pCMV-PrPLII 100 ug DNA 3 times -70 -42 symptomatic 138.0 4 65.0 4 1.12 0 Fernandez-Borges 2006 2006 http://www.ncbi.nlm.nih.gov/pubmed/17005675 http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1617305/ Fernandez-Borges Rodriguez mice 129/Ola wt 1 BSE1 0.1 20 i.c. i.m. pCMV pCMV vaccination pCMV-PrP 100 ug DNA 3 times -70 -42 survival 140.0 4 140.0 4 0.00 1 Fernandez-Borges 2006 2006 http://www.ncbi.nlm.nih.gov/pubmed/17005675 http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1617305/ Fernandez-Borges Rodriguez mice 129/Ola wt 1 BSE1 0.1 20 i.c. i.m. pCMV pCMV vaccination pCMV-UbPrP 100 ug DNA 3 times -70 -42 survival 154.0 4 140.0 4 0.10 1 Fernandez-Borges 2006 2006 http://www.ncbi.nlm.nih.gov/pubmed/17005675 http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1617305/ Fernandez-Borges Rodriguez mice 129/Ola wt 1 BSE1 0.1 20 i.c. i.m. pCMV pCMV vaccination pCMV-PrPLII 100 ug DNA 3 times -70 -42 survival 148.0 4 140.0 4 0.06 1 Pflanz 2009 2009 http://www.ncbi.nlm.nih.gov/pubmed/19088298 http://vir.sgmjournals.org/content/90/1/269.full Pflanz Weiss mice wt 1 RML 0.01 20 i.c. i.c. lentivirus LVsiRNA-Lamin A/C gene therapy LVsiRNA-LRP 7 2.1e6 TU -42 -42 symptomatic 145.0 0.0 139.0 0.0 0.04 0.005 0 Pflanz 2009 2009 http://www.ncbi.nlm.nih.gov/pubmed/19088298 http://vir.sgmjournals.org/content/90/1/269.full Pflanz Weiss mice wt 1 RML 0.01 20 i.c. i.c. lentivirus LVsiRNA-Lamin A/C gene therapy LVsiRNA-LRP 9 2.1e6 TU -42 -42 symptomatic 143.0 3.0 139.0 0.0 0.03 0.05 0 Pflanz 2009 2009 http://www.ncbi.nlm.nih.gov/pubmed/19088298 http://vir.sgmjournals.org/content/90/1/269.full Pflanz Weiss mice wt 1 RML 0.01 20 i.c. i.c. lentivirus LVsiRNA-Lamin A/C gene therapy LVsiRNA-LRP 7 2.1e6 TU -42 -42 survival 160.0 4.0 155.0 4.0 0.03 0.05 0 Pflanz 2009 2009 http://www.ncbi.nlm.nih.gov/pubmed/19088298 http://vir.sgmjournals.org/content/90/1/269.full Pflanz Weiss mice wt 1 RML 0.01 20 i.c. i.c. lentivirus LVsiRNA-Lamin A/C gene therapy LVsiRNA-LRP 9 2.1e6 TU -42 -42 survival 161.0 10.0 155.0 4.0 0.04 0.5 0 Mayer-Sonnenfeld 2008 2008 http://www.ncbi.nlm.nih.gov/pubmed/18350378 Mayer-Sonnenfeld Gabizon mice C57BL wt 1 RML 0.01 i.p. p.o. small molecule tilorone 50 mg/kg/day dissolved in drinking water 50.0 283.8 0 3 survival 213.4 4.0 211.0 11.9 0.01 1 0 Mayer-Sonnenfeld 2008 2008 http://www.ncbi.nlm.nih.gov/pubmed/18350378 Mayer-Sonnenfeld Gabizon mice C57BL wt 1 RML 0.01 i.p. p.o. small molecule tilorone 50 mg/kg/day dissolved in drinking water 50.0 283.8 -30 0 survival 225.4 7.0 211.0 11.9 0.07 0.01 0 Mayer-Sonnenfeld 2008 2008 http://www.ncbi.nlm.nih.gov/pubmed/18350378 Mayer-Sonnenfeld Gabizon mice C57BL wt 1 RML 0.01 i.p. p.o. small molecule tilorone 50 mg/kg/day dissolved in drinking water 50.0 283.8 -30 3 survival 233.3 4.4 211.0 11.9 0.11 0.01 0 Mayer-Sonnenfeld 2008 2008 http://www.ncbi.nlm.nih.gov/pubmed/18350378 Mayer-Sonnenfeld Gabizon mice C57BL wt 1 RML 0.01 i.p. p.o. small molecule tilorone 50 mg/kg/day dissolved in drinking water 50.0 283.8 -30 30 survival 245.0 8.4 211.0 11.9 0.16 0.01 0 Sethi 2002 2002 http://www.ncbi.nlm.nih.gov/pubmed/12133662 Sethi Kretzschmar mice wt 1 RML 0.1 100 i.p. i.p. vaccination CpG oligodeoxynucleotide 1826 30 uL 0h after infection and daily for 4 days 0 4 survival 253.0 4.0 8 1 183.0 7.0 8 1 0.38 0.0001 0 Sethi 2002 2002 http://www.ncbi.nlm.nih.gov/pubmed/12133662 Sethi Kretzschmar mice wt 1 RML 0.1 100 i.p. i.p. vaccination CpG oligodeoxynucleotide 1826 30 uL 7h after infection and daily for 4 days 0 4 survival 250.0 6.0 8 1 181.0 3.0 8 1 0.38 0.0005 0 Sethi 2002 2002 http://www.ncbi.nlm.nih.gov/pubmed/12133662 Sethi Kretzschmar mice wt 1 RML 0.1 100 i.p. i.p. vaccination CpG oligodeoxynucleotide 1826 30 uL 7h after infection and daily for 20 days 0 20 survival 330.0 8 0 330 181.0 3.0 8 1 0.82 0.0005 0 Mabbott 2002 2002 http://www.ncbi.nlm.nih.gov/pubmed/11967328 http://jvi.asm.org/content/76/10/5131.full.pdf Mabbott Bruce mice C57BL wt 1 ME7 70 0.01 20 i.c. i.p. huIg macromolecule huTNFR:Fc a single intraperitoneal (i.p.) injection of 100 g of a dimeric fusion protein containing the soluble human TNFR (huTNFR) (p80) domain linked to the Fc portion of human immunoglobulin G1 -5 -5 survival 168.0 6 1 164.0 6 1 0.02 1 0 Mabbott 2002 2002 http://www.ncbi.nlm.nih.gov/pubmed/11967328 http://jvi.asm.org/content/76/10/5131.full.pdf Mabbott Bruce mice C57BL wt 1 ME7 70 0.01 20 i.c. i.p. huIg macromolecule huTNFR:Fc a single intraperitoneal (i.p.) injection of 100 g of a dimeric fusion protein containing the soluble human TNFR (huTNFR) (p80) domain linked to the Fc portion of human immunoglobulin G1 14 14 survival 168.0 6 1 172.0 6 1 -0.02 1 0 Mabbott 2002 2002 http://www.ncbi.nlm.nih.gov/pubmed/11967328 http://jvi.asm.org/content/76/10/5131.full.pdf Mabbott Bruce mice C57BL wt 1 ME7 70 0.01 20 i.p. i.p. huIg macromolecule huTNFR:Fc a single intraperitoneal (i.p.) injection of 100 g of a dimeric fusion protein containing the soluble human TNFR (huTNFR) (p80) domain linked to the Fc portion of human immunoglobulin G1 -5 -5 survival 302.0 7.0 8 1 255.0 15.0 8 1 0.18 0.01 0 Mabbott 2002 2002 http://www.ncbi.nlm.nih.gov/pubmed/11967328 http://jvi.asm.org/content/76/10/5131.full.pdf Mabbott Bruce mice C57BL wt 1 ME7 70 0.001 20 i.p. i.p. huIg macromolecule huTNFR:Fc a single intraperitoneal (i.p.) injection of 100 g of a dimeric fusion protein containing the soluble human TNFR (huTNFR) (p80) domain linked to the Fc portion of human immunoglobulin G1 -5 -5 survival 353.0 4.0 9 1 315.0 7.0 9 1 0.12 0.001 0 Mabbott 2002 2002 http://www.ncbi.nlm.nih.gov/pubmed/11967328 http://jvi.asm.org/content/76/10/5131.full.pdf Mabbott Bruce mice C57BL wt 1 ME7 70 0.0001 20 i.p. i.p. huIg macromolecule huTNFR:Fc a single intraperitoneal (i.p.) injection of 100 g of a dimeric fusion protein containing the soluble human TNFR (huTNFR) (p80) domain linked to the Fc portion of human immunoglobulin G1 -5 -5 survival 466.4 9 0.777777778 500 424.9 9 0.555555556 0.10 0 Authors provided average survival for non-censored mice; these numbers include censored Mabbott 2002 2002 http://www.ncbi.nlm.nih.gov/pubmed/11967328 http://jvi.asm.org/content/76/10/5131.full.pdf Mabbott Bruce mice C57BL wt 1 ME7 70 0.01 20 i.p. i.p. huIg macromolecule huTNFR:Fc a single intraperitoneal (i.p.) injection of 100 g of a dimeric fusion protein containing the soluble human TNFR (huTNFR) (p80) domain linked to the Fc portion of human immunoglobulin G1 -5 -5 survival 302.0 255.0 0.18 0 Mabbott 2002 2002 http://www.ncbi.nlm.nih.gov/pubmed/11967328 http://jvi.asm.org/content/76/10/5131.full.pdf Mabbott Bruce mice C57BL wt 1 ME7 70 0.01 20 i.p. i.p. huIg macromolecule huTNFR:Fc a single intraperitoneal (i.p.) injection of 100 g of a dimeric fusion protein containing the soluble human TNFR (huTNFR) (p80) domain linked to the Fc portion of human immunoglobulin G1 14 14 survival 281.0 7.0 8 1 252.0 8.0 8 1 0.12 0 Mabbott 2002 2002 http://www.ncbi.nlm.nih.gov/pubmed/11967328 http://jvi.asm.org/content/76/10/5131.full.pdf Mabbott Bruce mice C57BL wt 1 ME7 70 0.01 20 i.p. i.p. huIg macromolecule huTNFR:Fc a single intraperitoneal (i.p.) injection of 100 g of a dimeric fusion protein containing the soluble human TNFR (huTNFR) (p80) domain linked to the Fc portion of human immunoglobulin G1 38 38 survival 266.0 263.0 0.01 0 Sadowski 2009 2009 http://www.ncbi.nlm.nih.gov/pubmed/19385058/ http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2713020/ Sadowski Wisniewski mice CD-1 F wt 1 22L 90 0.1 100 i.p. i.p. PBS IgG antibody 6D11 "1 mg 1 hour after inoculation, 0.5 mg twice per week" 0.1 0.8 0 28 survival 215.0 15 1 157.0 15 1 0.37 0.0001 0 I consider the 4 week IgG group as the control Sadowski 2009 2009 http://www.ncbi.nlm.nih.gov/pubmed/19385058/ http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2713020/ Sadowski Wisniewski mice CD-1 F wt 1 22L 90 0.1 100 i.p. i.p. PBS IgG antibody 6D11 "1 mg 1 hour after inoculation, 0.5 mg twice per week" 0.1 0.8 0 56 survival 211.5 15 1 157.0 15 1 0.35 0.0001 0 I consider the 8 week IgG group as the control Lu & Giles 2013 2013 http://www.ncbi.nlm.nih.gov/pubmed/23965382 http://jpet.aspetjournals.org/content/early/2013/08/21/jpet.113.205799.long Lu Prusiner mice FVB/N wt 1 RML 56 0.01 30 i.c. p.o. 1.25% PEG400 in chocolate liquid diet small molecule cpd-B 110 mg/kg/day in liquid diet 110.0 624.3 1 bioluminescence 200.0 10 55.0 8 2.64 Lu & Giles 2013 2013 http://www.ncbi.nlm.nih.gov/pubmed/23965382 http://jpet.aspetjournals.org/content/early/2013/08/21/jpet.113.205799.long Lu Prusiner mice FVB/N wt 1 RML 56 0.01 30 i.c. p.o. 1.25% PEG400 in chocolate liquid diet small molecule cpd-B 110 mg/kg/day in liquid diet 110.0 624.3 1 survival 219.0 21.0 10 108.0 1.0 8 1.03 Lu & Giles 2013 2013 http://www.ncbi.nlm.nih.gov/pubmed/23965382 http://jpet.aspetjournals.org/content/early/2013/08/21/jpet.113.205799.long Lu Prusiner mice FVB/N Tg4053 wt 4 RML 56 0.01 30 i.c. p.o. 1.25% PEG400 in chocolate liquid diet small molecule cpd-B 110 mg/kg/day in liquid diet 110.0 624.3 1 bioluminescence 120.0 12 30.0 15 3.00 Lu & Giles 2013 2013 http://www.ncbi.nlm.nih.gov/pubmed/23965382 http://jpet.aspetjournals.org/content/early/2013/08/21/jpet.113.205799.long Lu Prusiner mice FVB/N Tg4053 wt 4 RML 56 0.01 30 i.c. p.o. 1.25% PEG400 in chocolate liquid diet small molecule cpd-B 110 mg/kg/day in liquid diet 110.0 624.3 1 survival 143.0 7.0 12 52.0 2.0 15 1.75 Lu & Giles 2013 2013 http://www.ncbi.nlm.nih.gov/pubmed/23965382 http://jpet.aspetjournals.org/content/early/2013/08/21/jpet.113.205799.long Lu Prusiner mice FVB/N wt 1 RML 56 0.01 30 i.c. p.o. 1.25% PEG400 in chocolate liquid diet small molecule cpd-B 110 mg/kg/day in liquid diet 110.0 624.3 60 survival 182.0 9.0 9 108.0 1.0 0.69 Lu & Giles 2013 2013 http://www.ncbi.nlm.nih.gov/pubmed/23965382 http://jpet.aspetjournals.org/content/early/2013/08/21/jpet.113.205799.long Lu Prusiner mice FVB/N wt 1 RML 56 0.01 30 i.c. p.o. 1.25% PEG400 in chocolate liquid diet small molecule cpd-B 110 mg/kg/day in liquid diet 110.0 624.3 78 survival 163.0 14.0 9 108.0 1.0 0.51 Lu & Giles 2013 2013 http://www.ncbi.nlm.nih.gov/pubmed/23965382 http://jpet.aspetjournals.org/content/early/2013/08/21/jpet.113.205799.long Lu Prusiner mice FVB/N Tg1014 Giles 2010 http://www.ncbi.nlm.nih.gov/pubmed/20695008 "MHu2M,M111V,M165V,E167Q" 1 MM1 sCJD 56 0.01 30 i.c. p.o. 1.25% PEG400 in chocolate liquid diet small molecule cpd-B 110 mg/kg/day in liquid diet 110.0 624.3 1 survival 78.0 1.0 5 80.0 1.0 13 -0.03 Priola 2003 2003 http://www.ncbi.nlm.nih.gov/pubmed/12934186 http://jid.oxfordjournals.org/content/188/5/699.full.pdf Priola Caughey mice Tg7 Race 1995 http://www.ncbi.nlm.nih.gov/pubmed/7576660 http://www.ncbi.nlm.nih.gov/pubmed/10623745 hamster wt 4.5 263K 21 0.1 50 i.p. i.p. PBS small molecule PcTS ".05 mL of 5mg/mL solution, 3x/week" 12.5 70.9 -28 -3 survival 150.0 10 90.0 12 0.67 1 Priola 2003 2003 http://www.ncbi.nlm.nih.gov/pubmed/12934186 http://jid.oxfordjournals.org/content/188/5/699.full.pdf Priola Caughey mice Tg7 Race 1995 http://www.ncbi.nlm.nih.gov/pubmed/7576660 http://www.ncbi.nlm.nih.gov/pubmed/10623745 hamster wt 4.5 263K 21 0.1 50 i.p. i.p. PBS small molecule PcTS ".05 mL of 5mg/mL solution, 3x/week" -14 -3 survival 150.0 13 90.0 12 0.67 1 Priola 2003 2003 http://www.ncbi.nlm.nih.gov/pubmed/12934186 http://jid.oxfordjournals.org/content/188/5/699.full.pdf Priola Caughey mice Tg7 Race 1995 http://www.ncbi.nlm.nih.gov/pubmed/7576660 http://www.ncbi.nlm.nih.gov/pubmed/10623745 hamster wt 4.5 263K 21 0.1 50 i.p. i.p. PBS small molecule PcTS ".05 mL of 5mg/mL solution, 3x/week" 0 28 survival 150.0 9 90.0 12 0.67 1 Priola 2003 2003 http://www.ncbi.nlm.nih.gov/pubmed/12934186 http://jid.oxfordjournals.org/content/188/5/699.full.pdf Priola Caughey mice Tg7 Race 1995 http://www.ncbi.nlm.nih.gov/pubmed/7576660 http://www.ncbi.nlm.nih.gov/pubmed/10623745 hamster wt 4.5 263K 21 0.1 50 i.p. i.p. PBS small molecule PcTS ".05 mL of 5mg/mL solution, one-time injection" -28 -28 survival 95.0 11 95.0 8 0.00 1 Priola 2003 2003 http://www.ncbi.nlm.nih.gov/pubmed/12934186 http://jid.oxfordjournals.org/content/188/5/699.full.pdf Priola Caughey mice Tg7 Race 1995 http://www.ncbi.nlm.nih.gov/pubmed/7576660 http://www.ncbi.nlm.nih.gov/pubmed/10623745 hamster wt 4.5 263K 21 0.1 50 i.p. i.p. PBS small molecule PcTS ".05 mL of 5mg/mL solution, one-time injection" -14 -14 survival 95.0 12 95.0 8 0.00 1 Priola 2003 2003 http://www.ncbi.nlm.nih.gov/pubmed/12934186 http://jid.oxfordjournals.org/content/188/5/699.full.pdf Priola Caughey mice Tg7 Race 1995 http://www.ncbi.nlm.nih.gov/pubmed/7576660 http://www.ncbi.nlm.nih.gov/pubmed/10623745 hamster wt 4.5 263K 21 0.1 50 i.p. i.p. PBS small molecule PcTS ".05 mL of 5mg/mL solution, one-time injection" 3 3 survival 95.0 15 95.0 8 0.00 1 Priola 2003 2003 http://www.ncbi.nlm.nih.gov/pubmed/12934186 http://jid.oxfordjournals.org/content/188/5/699.full.pdf Priola Caughey mice Tg7 Race 1995 http://www.ncbi.nlm.nih.gov/pubmed/7576660 http://www.ncbi.nlm.nih.gov/pubmed/10623745 hamster wt 4.5 263K 21 0.1 50 i.p. i.p. PBS small molecule PcTS ".05 mL of 5mg/mL solution, one-time injection" 0 0 survival 95.0 9 95.0 8 0.00 1 Priola 2003 2003 http://www.ncbi.nlm.nih.gov/pubmed/12934186 http://jid.oxfordjournals.org/content/188/5/699.full.pdf Priola Caughey mice Tg7 Race 1995 http://www.ncbi.nlm.nih.gov/pubmed/7576660 http://www.ncbi.nlm.nih.gov/pubmed/10623745 hamster wt 4.5 263K 21 0.01 50 i.p. i.p. PBS small molecule PcTS Priola 2003 2003 http://www.ncbi.nlm.nih.gov/pubmed/12934186 http://jid.oxfordjournals.org/content/188/5/699.full.pdf Priola Caughey mice Tg7 Race 1995 http://www.ncbi.nlm.nih.gov/pubmed/7576660 http://www.ncbi.nlm.nih.gov/pubmed/10623745 hamster wt 4.5 263K 21 0.01 50 i.p. i.p. PBS small molecule PcTS Priola 2003 2003 http://www.ncbi.nlm.nih.gov/pubmed/12934186 http://jid.oxfordjournals.org/content/188/5/699.full.pdf Priola Caughey mice Tg7 Race 1995 http://www.ncbi.nlm.nih.gov/pubmed/7576660 http://www.ncbi.nlm.nih.gov/pubmed/10623745 hamster wt 4.5 263K 21 0.01 50 i.p. i.p. PBS small molecule PcTS Priola 2003 2003 http://www.ncbi.nlm.nih.gov/pubmed/12934186 http://jid.oxfordjournals.org/content/188/5/699.full.pdf Priola Caughey mice Tg7 Race 1995 http://www.ncbi.nlm.nih.gov/pubmed/7576660 http://www.ncbi.nlm.nih.gov/pubmed/10623745 hamster wt 4.5 263K 21 0.01 50 i.c. i.p. PBS small molecule PcTS ".05 mL of 5mg/mL solution, 3x/week"