Archives

2013-06-14: Histone marks at 5′ vs. 3′ ends of genes: a gentle slope or sudden dropoff?
2013-06-11: Timepoint-delay plots for comparing prion therapeutics tested in vivo
2013-06-08: A simple mathematical example of the glycoform “selection model”
2013-06-08: Facts about prion kinetics
2013-06-08: A “magic threshold” of PrP knockdown to reverse prion disease?
2013-06-08: A tour of the Zon lab and our introduction to zebrafish
2013-06-01: PrPC downregulation in prion infection
2013-06-01: GPM6A: an early biomarker of prion infection?
2013-06-01: 2-aminothiazoles: exciting progress and lessons for the field
2013-06-01: Updates on clinical trials of doxycycline for CJD at Prion2013
2013-05-24: A comparison of statin studies in scrapie-infected mice
2013-05-18: Updates on gene therapy for prion diseases
2013-05-15: Regulation of prion protein transcription
2013-05-05: Prion protein N-linked glycosylation: review and assessment of therapeutic potential
2013-05-05: Current status of efforts to delay genetic prion disease in humans
2013-05-02: Review of prion protein and amyloid beta interactions
2013-05-02: R equivalent of SQL coalesce
2013-05-01: Cell Biology 12: Stem Cells and Cancers
2013-04-30: Slope or correlation, not variance explained, allow estimation of heritability
2013-04-28: Cell Biology 11: Apoptosis & Necrosis
2013-04-26: Translating timepoints from mouse trials into human clinical trials
2013-04-26: anle138b: the new most promising experimental compound for treating prion diseases
2013-04-20: Blood lipids and prion diseases
2013-04-20: Cell Biology 10: Regulation of Transcription Through Signal Transduction
2013-04-16: Cell Biology 09: Signal Transduction
2013-04-11: Four quick proteomics analyses using PostgreSQL and R
2013-04-08: Half life of PrP and its mRNA
2013-04-08: The case for depleting PrP as a therapeutic strategy against prion diseases
2013-04-08: Review of drugs used in humans with prion disease
2013-04-08: Passive immunization against PrP
2013-04-06: Cell Biology 08: Cell Cycle Regulation and Checkpoints
2013-04-04: Tacrolimus, astemizole and a new screening approach for drugs that reduce PrP
2013-04-03: Association of repeat length polymorphisms with complex traits and common diseases
2013-03-31: PRNP deletions in 1000 Genomes are not real
2013-03-30: Cell Biology 07: Microtubules and Cell Division
2013-03-20: Can humans live without PrP?
2013-03-19: Automatically creating pivot table column names in PostgreSQL
2013-03-17: Polyene antifungal drugs for prion disease
2013-03-15: Mapping proteomics data to UniProt, RefSeq and gene symbols
2013-03-14: Fatal familial insomnia and the boy girl paradox
2013-03-12: Why we recommend 23andMe to everyone we know
2013-03-10: Cell Biology 06: The Cytoskeleton Part II: Tubulin
2013-03-06: 23andMe’s coverage of rare prion diseases
2013-03-05: Heritability and genetic modifiers in Mendelian diseases
2013-03-03: Prospects for gene therapy of prion diseases
2013-03-02: Cell Biology 05: The Cytoskeleton Part I: Actin
2013-02-28: Help us win $10,000 for prion disease research
2013-02-24: Cell Biology 04: The Secretory Pathway
2013-02-17: Environmental modifiers for Huntington’s age of onset?
2013-02-17: Cell Biology 03: Targeting proteins to organelles
2013-02-12: Finding all the polyQ genes in the human genome
2013-02-10: Cell Biology 02: The Plasma Membrane
2013-02-05: Fatal familial insomnia as a sleep disorder
2013-02-04: How to calculate heritability
2013-02-01: The decoy genome
2013-01-31: Mitochondrial heteroplasmy
2013-01-30: Center for Human Genetic Research 2013 Retreat
2013-01-29: Sampling a matching distribution for bootstrapping
2013-01-27: PrP / amyloid beta interactions and the prion disease / Alzheimer’s connection
2013-01-25: Aligning unmapped reads to viral genomes
2013-01-24: How synonymous are synonymous SNPs?
2013-01-23: Huntington’s Disease phenotypes in cell culture
2013-01-21: Advances in cell reprogramming
2013-01-19: TALENs and ZFNs
2013-01-09: Testing for repeat length association with phenotype using lobSTR
2013-01-08: Calling repeat length polymorphisms with lobSTR
2012-12-31: Electroconvulsive therapy, oxidative stress and prion disease
2012-12-28: Tips for dealing with NHGRI GWAS catalog data
2012-12-27: Biosafety levels for dealing with prions
2012-12-27: How to identify a disease-associated repeat expansion
2012-12-19: Forward and reverse reads in paired-end sequencing
2012-12-17: Chlorpromazine: another prion therapeutic of yesteryear
2012-12-14: Resources for systems biology in prion disease
2012-12-14: UAB day 4: analytical approaches
2012-12-13: The rise and fall of pentosan polysulfate in prion disease
2012-12-13: UAB day 3: models and tools
2012-12-12: UAB day 2: analysis, expression and epigenomics
2012-12-11: How PCR duplicates arise in next-generation sequencing
2012-12-11: UAB day 1: intro to sequencing
2012-12-10: Huntington’s disease reading list
2012-12-06: Indometacin and the anti-inflammatory approach
2012-12-05: Power for GWAS and extreme phenotype studies
2012-12-03: Introduction to fatal familial insomnia
2012-12-03: Log-rank test power depends on variance
2012-12-01: Memantine
2012-12-01: Adverse effects of ibuprofen
2012-11-30: Power analysis for mouse studies using the t test vs. log-rank test
2012-11-29: PET with fluorodeoxyglucose as pre-symptomatic FFI diagnostic
2012-11-29: Student’s t test vs. log-rank test for mouse studies
2012-11-29: Dapsone
2012-11-28: Background on heritability in Huntington’s Disease age of onset
2012-11-28: The role of oxidation and Coenzyme Q in prion disease
2012-11-26: Advances in imaging of prion disease progression in mice and humans
2012-11-26: More about minocycline
2012-11-25: Promising molecules from high-throughput screening in the Groschup lab
2012-11-25: Resveratrol
2012-11-24: Porphyrin and phthalocyanine compounds
2012-11-24: Curcumin as prion therapeutic
2012-11-24: An introduction to high-throughput screening and its relevance to prion therapeutics
2012-11-18: Anti-PrP vaccines
2012-11-16: An introduction to Walker Jackson’s fatal familial insomnia knock-in mice
2012-11-16: Can a human PRNP disease gene be knocked into mice?
2012-11-14: Multiple alignment of mammalian PrP amino acid sequences
2012-11-13: The difference between knock-in and transgenic mice
2012-11-12: annovar with GRCh37
2012-11-11: We’re back
2012-10-25: Population Substructure, Part II
2012-10-23: Scutellaria lateriflora
2012-10-23: Fluphenazine, trimipramine and two styryl compounds
2012-10-23: Quinacrine
2012-10-23: Check out PrionAlliance.org
2012-10-17: Descriptive statistics and quality control on variants
2012-10-16: Imaging of amyloid plaques
2012-10-15: How (and why) to create population covariates using 1000 Genomes data
2012-10-06: Screen reveals antiprion compounds that act indirectly
2012-10-06: VPSPr: another strain of sporadic prion disease
2012-09-28: Statins as prion therapeutics
2012-09-28: Exosome miRNA signatures offer a possible prion diagnostic tool
2012-09-25: cpd-B as a prion therapeutic
2012-09-25: Implementation of RVT1 and RVT2 in R and SQL
2012-09-19: Exome sequencing pipeline using GATK
2012-09-14: The history of tetracyclines as treatments for prion disease
2012-09-13: Rapamycin delays disease onset in GSS mice
2012-09-07: An alternative exome sequencing pipeline using bowtie2 and samtools
2012-09-07: Issues with the conventional BWA-Picard-GATK exome sequencing pipeline
2012-09-07: Improvements in GATK 2.x
2012-08-27: FastQC for large numbers of samples
2012-08-17: SNP databases
2012-08-17: Exome sequencing reveals disease modifiers for cystic fibrosis
2012-08-15: QQ plots with matplotlib
2012-08-13: Biological and statistical considerations in exome analysis
2012-08-13: Getting started with analyzing sequence data
2012-08-06: Genome-wide association studies
2012-08-03: How Tafamidis was born
2012-08-02: Exome sequencing and analysis
2012-08-02: Huntington’s becomes the huntingted
2012-07-04: Adiga on Bright Field Microscopy
2012-07-01: Visualizing staining variation using matplotlib
2012-06-28: New expression pattern data access from the Allen Institute
2012-06-24: Pentosan Polysulfate
2012-06-24: House prescribes Amphotericin
2012-06-11: The magic of blur and contrast
2012-06-07: Stem cell assays by the numbers
2012-06-06: Literature review: image segmentation on H&E-stained tissue samples
2012-05-16: Endoplasmic reticulum and the Golgi apparatus
2012-05-13: Color transformations for segmenting complex images
2012-04-26: Luminescent conjugated polymers
2012-04-22: Using the nasal-CNS connection to bypass the BBB
2012-04-20: Circadian rhythm regulators
2012-04-16: secondary oligomer as toxic species
2012-04-13: Diagnostic clinical study ongoing at UCSF
2012-04-13: Trimipramine and Fluphenazine
2012-04-13: CellProfiler in command line mode
2012-04-13: Convolutional Networks continued
2012-03-31: More on Convolutional Networks and Machine Learning
2012-03-31: Making sense of the Allen Institute mouse brain images
2012-03-31: iPS cells and neurodifferentiation
2012-03-27: Turaga, Murray 2010 – Convolutional Networks Can Learn to Generate Affinity Graphs for Image Segmentation
2012-03-25: Mouse brain images from the Allen Institute for Brain Science
2012-03-24: Jain 2010 – Machines that learn to segment images: a crucial technology for connectomics
2012-03-24: Jones 2009 – Scoring diverse cellular morphologies in image-based screens with iterative feedback and machine learning
2012-03-24: Kamentsky 2011 – Improved structure, function, and compatibility for CellProfiler: modular high-throughput image analysis software
2012-03-24: Histology, high-throughput screening and prion therapeutics
2012-03-19: Disulfide Bonds
2012-03-10: Prion workshop day 3
2012-03-10: Prion workshop day 2
2012-03-10: Prion workshop day 1
2012-02-29: Shape shifting: protein statistical physics as a linear programming problem
2012-02-29: The origin of Walker Jackson’s FFI knock-in mice
2012-02-28: Lindquist lab follows up on yeast prion epigenetics
2012-02-24: Chaperonin nano-cages
2012-02-24: Heat shock protein review article
2012-02-24: Background on chaperones
2012-02-21: The state of gene therapy for HIV
2012-02-19: Coming soon in DNA sequencing technology
2012-02-18: Review article on why PrP exists
2012-02-18: Structure of FFI prion protein
2012-02-17: Bone marrow transplants and neurodegeneration
2012-02-17: More good reasons to eat turmeric
2012-02-17: Nanobiotechnology and DNA origami
2012-02-15: Autophagy and neuroprotection
2012-02-14: A quick tour of the brain
2012-02-10: Cancer Drug ‘Rapidly Clears’ Beta-Amyloid Plaques in Mice
2012-02-07: Science Night 2012.02.06
2012-02-07: Kuru and the G127V Polymorphism
2012-02-07: Finding the PRNP Gene Sequence
2012-02-05: I found this article which may be of…
2012-02-03: History of FFI by the New York Times
2012-02-02: Alzheimer’s spreads through infectious tau proteins
2012-02-02: Heat shock transcription factors and protein chaperones
2012-01-22: Prion lectures by Susan Lindquist
2012-01-18: Clinical trial for doxycycline in FFI carriers will run from 2011-2022
2012-01-18: Materials from the annual CJD foundation family conference
2012-01-18: Science night notes 2012.01.16
2012-01-18: Allele-specific gene silencing using siRNA
2012-01-17: A helpful review from 2003 by Detlev Risener…
2012-01-11: Orphan drugs
2012-01-11: Spread of PrP(Sc) in vCJD — follicular dendritic cells
2012-01-11: Cholesterol and lipids
2012-01-10: Oxidative stress and metals
2012-01-10: Prion replication vs. neurotoxicity
2012-01-10: Antisense therapy
2012-01-10: Crossing the blood-brain barrier
2012-01-09: Bruce’s notes for phone call 2011.12.24
2012-01-08: Labs and resources
2012-01-08: Other potentially therapeutic drugs
2012-01-08: Native function of PrP(c)
2012-01-08: Bioinformatics
2012-01-08: Link to Alzheimer’s
2012-01-08: Beta amyloid and melatonin
2012-01-08: Genomics
2012-01-08: Autophagy
2012-01-08: Tetracyclines
2012-01-08: Regenerative medicine/ stem cell therapy
2012-01-08: Prion protein folding
2012-01-08: Glossary Part 3
2012-01-08: Epigenetics
2012-01-08: Gene therapy
2012-01-08: Chemical chaperones
2012-01-08: Immunotherapy treatment
2012-01-08: Glossary Part 2
2012-01-08: Agrypnia excitata
2012-01-08: Nutrition
2012-01-08: Glossary Part 1
2012-01-06: The gene sequence for FFI

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Archives