everything · no notes
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2024-09-23 — DNA methylation: durability and what's unique about the brain
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2024-08-16 — ION717 trial resumes recruitment
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2024-06-28 — RNATx 2024
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2024-06-27 — Introducing CHARM
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2024-06-21 — DNA methylation primer
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2024-05-22 — A big step forward for brain delivery of gene therapies
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2024-05-06 — What if drugs can affect NfL by clearance?
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2024-04-11 — Why the ION717 trial is paused
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2024-04-03 — What can we learn about PRNP from gnomAD v4?
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2024-03-21 — End of the beginning
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2024-02-29 — Evidence that PrP GPI signal sequence matters
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2023-12-28 — A cryptic exon to lower PrP
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2023-12-21 — First ION717 trial site launches
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2023-12-20 — Biomarker changes before disease onset in our MGH cohort study
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2023-12-04 — First details of Ionis trial disclosed
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2023-10-04 — Ionis re-commits to new timeline for prion disease ASO trials
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2023-05-17 — Duration of prodrome and of disease
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2023-05-16 — ASOs at single cell resolution
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2023-04-25 — Tofersen is now the closest thing so far
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2023-02-21 — STX6: validating and invalidating a drug target in the same breath
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2022-11-30 — Second dispatch from the London cohort
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2022-11-01 — ASOs and hydrocephalus
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2022-10-24 — Prevention and targeted therapies are not business as usual
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2022-10-12 — Lessons from that first crowdfunded experiment in 2013
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2022-09-07 — Not every drug has its target
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2022-08-23 — All the non-human primate studies
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2022-07-27 — How many patients do we have?
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2022-03-30 — Antisense candidate for C9orf72 ALS fails
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2022-03-17 — Results in from PRN100 antibody first-in-human dosing
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2022-01-21 — Tominersen being rebooted for early HD
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2021-12-16 — The Lancet Summit: presymptomatic prevention and treatment of neurodegenerative diseases
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2021-11-04 — Clinical laboratory tests: what's in a number?
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2021-10-18 — Middling results for tofersen in SOD1 ALS
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2021-08-10 — The role of different brain cell types in prion disease
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2021-04-28 — Details emerge on tominersen trial halt
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2021-04-08 — RNA therapeutic news roundup Q1 2021
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2021-04-07 — Ionis pivots on PRNP candidate
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2021-03-24 — Huntington's disease ASO trial halted
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2021-01-11 — RNA therapeutic news roundup for 2020
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2021-01-07 — The NIH/KOMP workshop on gene essentiality
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2020-08-18 — The London study: plasma NfL in pre-symptomatic genetic prion disease
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2020-06-23 — Five years of screening, not one advanceable hit
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2020-05-27 — The variants you see and the variants you don't see
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2020-05-04 — A glimpse of non-PRNP genetic risk factors for prion disease
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2020-04-30 — The natural history of prion disease in mice
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2020-03-31 — ASOs work
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2020-03-22 — Birth announcement
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2020-03-19 — Our preventive clinical strategy in genetic prion disease
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2020-03-03 — PrP antibodies in humans: the experiments of nature
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2020-02-24 — Is peripheral neuropathy in prion disease caused by a loss of PrP function?
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2020-01-08 — The anticipation parallelogram
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2019-12-17 — First results in from our MGH clinical research study
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2019-12-04 — Is PRNP associated to any human traits besides prion disease?
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2019-10-25 — Anastasia Khvorova: oligonucleotide therapeutics, the future of human medicine
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2019-09-20 — Roland Herzog: de-immunizing AAV
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2019-09-12 — Developments and challenges in degradation-targeting chimeras
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2019-09-09 — Come join our team
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2019-09-07 — AGBT-PH 2019
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2019-08-29 — Antisense part V: safety
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2019-07-23 — What gene therapy can and can't do today
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2019-07-16 — PRN100 antibody first-in-human
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2019-07-14 — CJD Foundation Family Conference 2019
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2019-06-18 — Antisense part IV: pharmacokinetics and cell biology
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2019-06-05 — Using genetic data to estimate disease prevalence
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2019-05-30 — Graduation day
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2019-05-23 — Prion2019 days 2-3 and poster session
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2019-05-21 — Prion2019 day 1: biomarker workshop
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2019-05-14 — What's the deal with GPI-anchored proteins?
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2019-04-29 — How pharmaceutical industry financial modelers think about your rare disease
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2019-04-04 — Measuring PrP in spinal fluid two different ways
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2019-01-28 — Using human loss-of-function variants to evaluate drug targets
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2018-12-06 — Prion disease is not one in a million
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2018-09-12 — What can loss-of-function variants predict about drug safety?
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2018-09-06 — Racing against a clock we can't see
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2018-08-28 — Antisense part III: chemistries
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2018-08-13 — FDA approval of the first RNAi drug
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2018-08-07 — Survey of fluid biomarkers in prion disease
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2018-07-25 — Antisense part II: mechanisms of action
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2018-07-15 — CJD Foundation Family Conference 2018
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2018-07-10 — Antisense part I: the basics
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2017-12-18 — Protective PrP missense variants
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2017-12-15 — Human prion propagation in cell culture
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2017-12-13 — Targeting glutamate receptors in prion disease
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2017-12-11 — Huntingtin becomes the huntingted
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2017-12-08 — Skin, surgery, and CJD
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2017-11-10 — Announcing the Prion Registry
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2017-10-25 — Aguzzi on tour
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2017-07-25 — Birth announcement
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2017-07-19 — Clinical research study launching at Massachusetts General Hospital
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2017-06-08 — Differential scanning fluorimetry for PrP: an assay development saga
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2017-06-07 — Recombinant prion protein QC
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2017-04-25 — Why do some PrP mutations cause disease?
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2017-04-24 — Annotating the literature on pathogenicity of PRNP variants
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2017-03-16 — How to compare clinical trial data to a natural history control?
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2017-03-03 — Preventive trial withdrawal rates
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2017-02-28 — Prions@Broad is hiring
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2017-01-17 — Food and Drug Law 10: Biologicals
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2017-01-12 — Food and Drug Law 08: Prescribing & Generics
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2017-01-11 — Food and Drug Law 07: Drug Development Continued; Labeling & Advertising
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2017-01-10 — Food and Drug Law 06: Regulation of Drugs
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2017-01-04 — Food and Drug Law 02: Jurisdiction & Enforcement
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2017-01-03 — Food and Drug Law 01: Introduction to FDA
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2016-12-13 — 21st Century Cures
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2016-11-17 — How to do a DNA-encoded library selection
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2016-11-14 — Thermodynamics in binding assays
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2016-11-09 — BroadE workshop on quantitative proteomics
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2016-10-20 — The deal with Accelerated Approval
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2016-10-19 — Estimation of penetrance using population allele frequency
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2016-09-12 — Isothermal titration calorimetry
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2016-08-19 — Presymptomatic imaging
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2016-08-16 — Native function update
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2016-08-02 — The role of microglia in prion disease
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2016-07-10 — CJD2016
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2016-07-06 — Mouse models of genetic prion disease
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2016-06-28 — Introductory prion reading list
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2016-06-03 — New Technologies Club lecture on cryo-electron microscopy
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2016-05-13 — Prion2016
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2016-05-08 — A mechanism of action hypothesis
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2016-04-27 — Differential scanning calorimetry
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2016-04-13 — Charting the PrP archipelago with TROSY
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2016-03-17 — John Ioannidis: the state of research on research
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2016-03-04 — BroadE workshop on fragment-based drug discovery
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2016-03-02 — What do we know about ApoE?
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2016-02-25 — Sonia speaks with President Obama about precision medicine
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2016-02-17 — Age of onset in genetic prion disease
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2016-02-16 — Q&A on genetic prion disease risk
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2016-01-20 — Does this mean I'll definitely get the disease?
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2016-01-13 — NMR fragment screening
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2016-01-07 — Proton NMR on recombinant PrP
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2015-12-27 — Circular dichroism on recombinant PrP
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2015-12-22 — Our first recombinant PrP prep at Broad
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2015-12-01 — Chemical biology 22: aging
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2015-11-24 — Chemical biology 21: stem cells and regenerative medicine
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2015-11-19 — Chemical biology 20: cancer stem cells
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2015-11-18 — A look at PrP knockdown screen data
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2015-11-17 — Chemical biology 19: oncogene addiction in cancer
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2015-11-12 — Chemical biology 18: a new view of diabetes
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2015-11-10 — Chemical biology 17: psychiatric disease
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2015-11-05 — Chemical biology 16: infectious disease
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2015-10-29 — Chemical biology tutorial 2: cheminformatics and small-molecule activity databases
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2015-10-27 — Chemical biology discussion 08: neglected tropical diseases
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2015-10-27 — Chemical biology 15: Diversity pathways leading to screening collections that have illuminated biology
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2015-10-22 — Chemical biology 14: Achieving stereochemical diversity
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2015-10-21 — Is there anything special about PrP's expression?
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2015-10-20 — Chemical biology discussion 07: diversity-oriented synthesis
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2015-10-20 — Chemical biology 13: Achieving skeletal diversity
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2015-10-15 — Chemical biology 12: Build/couple/pair in diversity-oriented synthesis
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2015-10-13 — Chemical biology discussion 06: bryostatin
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2015-10-13 — Chemical biology 11: Target-oriented next-generation synthesis
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2015-10-09 — Is PRNP mRNA alternatively spliced?
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2015-10-08 — Chemical biology 10: Chromatin and small-molecule modulators
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2015-10-06 — Chemical biology 09: Immunophilins and small-molecule modulators
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2015-10-01 — Chemical biology 08: The role of natural products in drug development
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2015-09-29 — Chemical biology discussion 04: FTO discussion
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2015-09-29 — Chemical biology 07: Origins of small molecules
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2015-09-24 — Chemical biology tutorial 1: cMAP workshop
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2015-09-23 — Small molecules to reduce one protein's expression
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2015-09-22 — Chemical biology discussion 03: grant writing
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2015-09-22 — Chemical biology 06: screening for drug discovery, target identification
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2015-09-21 — The N-terminal toxicity hypothesis
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2015-09-20 — The math behind Spearman-Karber analysis
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2015-09-17 — Chemical biology 05: Using small molecules to understand life processes
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2015-09-15 — Chemical biology 04: Gene expression
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2015-09-09 — Proposal writing 1: Introduction
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2015-09-01 — Polythiophenes go in vivo
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2015-08-24 — Thalidomide's renaissance
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2015-08-02 — Two more chapters for 2-aminothiazoles
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2015-07-22 — Reports of small molecule PrPC ligands
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2015-07-12 — Summaries of the CJD2015 conference talks
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2015-06-19 — The curious antiprion activity of antimalarial quinolines
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2015-06-10 — The powerful protective effect of G127V
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2015-06-01 — Prion2015 posters
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2015-05-29 — Prion2015 Day 4
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2015-05-28 — Prion2015 Day 3
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2015-05-27 — Prion2015 Day 2
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2015-05-26 — Prion2015 Day 1
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2015-05-15 — Protein folding term paper: Deciphering the disease mechanism of SOD1 ALS
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2015-05-14 — Protein folding 14: Amyloids and prions, Alzheimer disease, and metals
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2015-05-07 — Protein folding 13: SecB, light chain amyloidosis, and Parkinson disease
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2015-04-30 — Protein folding 12: Trigger factor and SOD1
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2015-04-30 — How do SOD1 mutations cause ALS?
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2015-04-29 — Organic chemistry 33: Mass spectrometry
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2015-04-27 — Organic chemistry 32: NMR spin-spin coupling
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2015-04-24 — Genetics in medicine 12: Blood lipids and myocardial infarction
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2015-04-24 — Organic chemistry 31: Proton NMR spectroscopy
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2015-04-23 — Protein folding 11: Etiology of disease and the beta helix model of amyloid
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2015-04-22 — Organic chemistry 30: Infrared and ultraviolet spectroscopy
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2015-04-21 — Are PrP levels in CSF a potential biomarker in prion disease?
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2015-04-20 — Measuring mHTT levels in CSF in Huntington disease
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2015-04-20 — Organic chemistry 29: Aromaticity - nucleophilic aromatic substitution, benzyne
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2015-04-17 — Genetics in medicine 11: Schizophrenia and bipolar disorder
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2015-04-17 — Organic chemistry 28: Aromaticity - electrophilic aromatic substitution
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2015-04-16 — Protein folding 10: Lessons from virology
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2015-04-15 — Completed clinical trials in prion disease
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2015-04-15 — Organic chemistry 27: Introduction to aromaticity
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2015-04-10 — Genetics in medicine 10: Lung cancer
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2015-04-10 — Organic chemistry 26: Diels-Alder cycloaddition
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2015-04-09 — Protein folding 09: Sickle cell disease
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2015-04-08 — Organic chemistry 25: Stereochemistry - diastereoselective and enantioselective reactions
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2015-04-06 — Backgrounder on SOD1
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2015-04-06 — Organic chemistry 24: Alkynes - reactions, synthesis and protecting groups
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2015-04-03 — Genetics in medicine 09: Alzheimer disease
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2015-04-03 — Organic chemistry 23: Radicals - allylic and benzylic bromination, cyclizations
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2015-04-02 — Protein folding 08: Chaperones and chaperonin
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2015-04-01 — Organic chemistry 22: Radicals - alkene halogenation, polymerization
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2015-03-30 — Organic chemistry 21: Alkenes - haloetherification, ozonolysis, diol cleavage
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2015-03-27 — Genetics in medicine 08: Inflammatory bowel disease
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2015-03-27 — Organic chemistry 20: Alkenes - oxymercuration, hydroboration
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2015-03-25 — Organic chemistry 19: Alkenes - epoxidation, dihydroxylation, cyclopropanation
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2015-03-19 — Protein folding 07: Collagen
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2015-03-13 — Genetics in medicine 07: von Hippel-Lindau
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2015-03-12 — Protein folding 06: Amyloid
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2015-03-11 — Organic chemistry 18: Electrophilic addition to alkenes
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2015-03-11 — Organic chemistry 17: Anchimeric assistance, epoxide transformations
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2015-03-09 — Organic chemistry 16: Stereochemistry - complex chirality, prochirality, topicity
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2015-03-06 — Genetics in medicine 06: Pitt-Hopkins syndrome
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2015-03-06 — Organic chemistry 15: Stereochemistry - meso compounds, resolution
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2015-03-05 — Protein folding 05: Partially folded intermediates
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2015-03-04 — Organic chemistry 14: Unimolecular beta elimination - carbocation rearrangements
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2015-03-02 — Organic chemistry 13: Bimolecular beta elimination (E2) - regioselectivity and stereoselectivity
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2015-02-27 — Genetics in medicine 05: Cystic fibrosis
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2015-02-27 — Organic chemistry 12: SN2 substitution - nucleophilicity, epoxide electrophiles
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2015-02-26 — Protein folding 04: Formation of alpha helices
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2015-02-25 — Organic chemistry 11: SN1 Substitution - carbocations, solvolysis, solvent effects
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2015-02-23 — Organic chemistry 10: Stereochemistry - chirality, enantiomers and diastereomers
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2015-02-20 — Genetics in medicine 04: Down syndrome
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2015-02-20 — Organic chemistry 09: Introduction to substitution and elimination
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2015-02-19 — Protein folding 03: Beta sheets
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2015-02-13 — Genetics in medicine 03: X-linked adrenoleukodystrophy
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2015-02-13 — Organic chemistry 08: Carbonyl conjugation, conformational analysis, cyclic compounds
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2015-02-12 — Protein folding 02: Alpha helices and coiled coils
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2015-02-11 — Organic chemistry 07: Carbonyls - organometallic nucleophiles, acidity and pKa
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2015-02-07 — Genetics in medicine 02: Mitochondrial disorders
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2015-02-06 — Organic chemistry 06: Carbonyls - nucleophilic additions, oxidation and reduction
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2015-02-05 — Protein folding 01: The protein folding problem
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2015-02-04 — Organic chemistry 05: Frontier molecular orbital theory
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2015-02-02 — Organic chemistry 04: Arrow-pushing: resonance, nucleophiles and electrophiles
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2015-01-30 — Genetics in medicine 01: Huntington disease
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2015-01-30 — Organic chemistry 03: Bonding - atomic orbitals and molecular orbitals
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2015-01-28 — Organic chemistry 02: Nomenclature and functional groups
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2015-01-27 — The search for genetic modifiers of prion disease
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2015-01-26 — Organic chemistry 01: What is organic chemistry, drawing structures
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2015-01-22 — The quest for the structure of PrPSc
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2015-01-13 — List of reportedly pathogenic PRNP variants
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2014-12-23 — Biolit midterm and final
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2014-12-21 — Structures of PrPC
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2014-12-15 — Neurodegeneration seminar 7: 'Unifying themes in neurodegenerative disease'
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2014-12-08 — Neurodegeneration seminar 6: 'polyQ proteins'
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2014-12-05 — Genetics 27: 'Epigenetics Part II'
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2014-12-04 — Biolit 11: complex genetics
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2014-12-03 — Molecular Biology 29: 'Paul Anderson\'s research seminar
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2014-12-03 — Genetics 26: 'Epigenetics Part I'
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2014-12-01 — Neurodegeneration seminar 5: 'Alpha synuclein'
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2014-11-24 — Neurodegeneration seminar 4: 'TDP-43 and C9orf72'
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2014-11-24 — Molecular Biology 28: 'Post-transcriptional regulation and RNA interference'
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2014-11-24 — We can, and should, do clinical trials in rare diseases
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2014-11-21 — Molecular Biology 27: 'Eukaryotic translation'
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2014-11-21 — Genetics 25: 'Mapping the genetic basis of complex phenotypes'
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2014-11-20 — Biolit 10: metabolism
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2014-11-19 — Primer on PCSK9 genetics
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2014-11-19 — Molecular Biology 26: 'Prokaryotic translation'
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2014-11-19 — Genetics 24: 'Complex traits, heritability, and the genetics of populations'
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2014-11-17 — Neurodegeneration seminar 3: 'tau'
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2014-11-14 — Molecular Biology 25: 'Stirling Churchman\'s research seminar'
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2014-11-14 — Genetics 23: 'Genetics in families and the analysis of Mendelian traits'
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2014-11-13 — Biolit 09: genome-wide approaches
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2014-11-12 — Molecular Biology 24: 'mRNA transport'
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2014-11-12 — Genetics 22: 'Genome variation in humans'
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2014-11-10 — Neurodegeneration seminar 2: 'Amyloid beta'
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2014-11-10 — Genetics 21: 'Mouse models of human disease'
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2014-11-10 — PrP transgene constructs
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2014-11-07 — Molecular Biology 23: 'mRNA processing'
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2014-11-07 — Genetics 20: 'How to do genetics in cultured somatic cells'
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2014-11-06 — Biolit 08: small RNAs
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2014-11-05 — Molecular Biology 22: 'Transcription termination'
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2014-11-05 — Genetics 19: 'Zebrafish genetics'
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2014-11-03 — Neurodegeneration seminar 1: 'Prions'
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2014-11-03 — Molecular Biology 21: 'Transcription elongation'
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2014-10-31 — Genetics 18: 'Modifier and mosaic screens in Drosophila'
-
2014-10-30 — Biolit 07: epigenetics
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2014-10-29 — Molecular Biology 20: 'Research seminar - CHD5 and cancer'
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2014-10-29 — Genetics 17: 'Forward genetic screens in Drosophila'
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2014-10-27 — Molecular Biology 19: 'Gene regulation V - nucleosomes and enhancers'
-
2014-10-27 — Genetics 16: 'Introduction to Drosophila: genotypes, recombination and balancer chromosomes'
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2014-10-24 — Molecular Biology 18: 'Gene regulation IV - transcription initiation'
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2014-10-22 — Genetics 15: 'How to study the neural basis of behavior using C. elegans'
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2014-10-20 — Molecular Biology 17: 'Gene regulation III - transcription'
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2014-10-20 — Genetics 14: 'C. Elegans methods workshop' or, 'Putting genes into pathways'
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2014-10-17 — Molecular Biology 16: 'Gene regulation II - chromatin remodeling'
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2014-10-17 — Genetics 13: 'How to study developmental mechanisms using C. elegans'
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2014-10-15 — Molecular Biology 15: 'Gene regulation I - histones and the histone code'
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2014-10-15 — Genetics 12: 'How to do a C. elegans screen'
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2014-10-10 — Some musings on age of death in FamiLinx
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2014-10-09 — Biolit 06: cytoskeletal dynamics
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2014-10-08 — Molecular Biology 14: 'Research seminar: mechanisms of interstrand cross-link (ICL) repair'
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2014-10-06 — Molecular Biology 13: 'Homologous recombination and non-homologous end-joining'
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2014-10-03 — Molecular Biology 12: 'Base excision repair (BER) and nucleotide excision repair (NER)'
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2014-10-02 — A cautionary tale of ascertainment bias in genetic disease age of onset
-
2014-10-02 — Biolit 05: protein aggregation
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2014-10-01 — Molecular Biology 11: 'Ribonucleotide excision repair (RER) and mismatch repair (MMR)'
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2014-10-01 — Genetics 11: 'Transposon sequencing (Tn-seq): how to identify mutants that die'
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2014-09-30 — The conformation holds the information
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2014-09-29 — Genetics 10: 'Genetic screens by example: virulence factor gene regulation'
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2014-09-26 — Molecular Biology 10: 'Research seminar: 'Mechanism of replication termination'
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2014-09-26 — Genetics 09: 'Transduction and Recombineering: a CRISPR case study'
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2014-09-25 — Biolit 04: bacterial pathogenesis
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2014-09-24 — Molecular Biology 09: 'Initiation of replication'
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2014-09-24 — Genetics 08: 'Bacterial Basics, Phages, and CRISPR elements'
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2014-09-22 — Molecular Biology 08: 'DNA replication and repair'
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2014-09-22 — Genetics 07: 'Cytoplasmic inheritance and complex traits'
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2014-09-18 — Biolit 03: cGAMP
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2014-09-17 — Molecular Biology 07: 'Research seminar - single molecule approaches'
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2014-09-17 — Genetics 06: 'Methods to find interacting proteins'
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2014-09-15 — Molecular Biology Workshop: PyMOL
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2014-09-15 — Molecular Biology 06: 'Chromosome structure'
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2014-09-15 — Genetics 05: 'Suppressor analysis in yeast'
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2014-09-12 — Molecular Biology 05: 'Protein-DNA interactions Part I'
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2014-09-12 — Genetics 04: 'Molecular and genomic studies in yeast'
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2014-09-11 — Biolit 02: protein targeting
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2014-09-10 — Molecular Biology 04: 'DNA structure and topology'
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2014-09-08 — Molecular Biology 03: 'Chemical kinetics and enzymes'
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2014-09-08 — Genetics 03: 'Linkage and tetrad analysis in yeast'
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2014-09-05 — Molecular Biology 02: 'Thermodynamics of protein folding'
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2014-09-05 — Genetics 02: 'Introduction to yeast genetics and complementation'
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2014-09-04 — Biolit 01: the plague
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2014-09-03 — Chlorpromazine: a new mechanism of action
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2014-09-03 — Molecular Biology 01: 'Introduction to protein structure'
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2014-09-03 — Genetics 01: 'What we learned from Mendel'
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2014-08-27 — Git tutorial
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2014-08-26 — A retrospective view of muscle disease in PrP-overexpressing mice
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2014-07-30 — Recombinant prion protein, Rocky Mountain-style
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2014-07-18 — Four flavors of CRISPR knockout screens
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2014-07-14 — Notes from the CJD2014 conference
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2014-07-10 — Our first RT-QuIC experiment
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2014-07-07 — Spontaneous conversion of D178N PrP in RT-QuIC
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2014-06-19 — RT-QuIC protocols in detail
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2014-06-04 — A proposal: how to tell if a cell-free assay is predictive of therapeutic potency in vivo
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2014-06-04 — Prion2014 Posters
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2014-05-30 — Prion2014 Day 4
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2014-05-29 — Prion2014 Day 3
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2014-05-28 — Prion2014 Day 2
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2014-05-27 — Prion2014 Day 1: Keynotes
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2014-05-27 — The overdrive hypothesis: is alpha cleavage key to keeping PrP in check?
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2014-05-15 — The kin-cohort method for estimating disease penetrance
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2014-05-15 — The difference between odds ratio and risk ratio
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2014-04-29 — Structural mutants of PrP
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2014-04-24 — Converting genetic variants to their minimal representation
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2014-04-24 — Gamma secretase inhibitors and prion disease
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2014-04-23 — Our next step
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2014-03-13 — Viral expression of antibodies in the brain as a therapeutic strategy in prion disease
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2014-03-09 — How to, and how not to, knock out PRNP
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2014-02-04 — Why doxycycline's failure in CJD clinical trials is no surprise
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2014-01-28 — Trends in NIH-funded prion grants
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2014-01-21 — Peripheral prion infection and the Y163X mutation
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2014-01-17 — A comparison of tools for calling CNVs from sequence data
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2014-01-16 — What's this Roche Brain Shuttle all about?
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2014-01-15 — Running R in batch mode on Linux
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2014-01-12 — Prion kinetic models and the relationship between inoculum titer and incubation time
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2014-01-02 — An introduction to Murcko fragments and structure-activity relationships using rcdk
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2013-12-18 — Why a simple exponential model of prion kinetics in vivo won't work
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2013-12-16 — Does spontaneous prion disease begin in the brain?
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2013-12-14 — How do prions travel from cell to cell?
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2013-12-13 — Biochemistry 12: diabetes
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2013-12-10 — A brief history of prion propagation in cell culture
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2013-12-06 — Biochemistry 11: regulation and integration
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2013-12-03 — Accounting for cell division and PrPSc availability in prion kinetic models
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2013-12-02 — Analytical solutions for a model of prion protein degradation
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2013-11-23 — Biochemistry 10: lipid metabolism
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2013-11-18 — An mRNA-seq pipeline using Gsnap, samtools, Cufflinks and BEDtools
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2013-11-18 — New high-throughput screening hits from the Prusiner lab
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2013-11-18 — Data from two high-throughput screens to deplete PrP available in PubChem
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2013-11-08 — Biochemistry 09: amino acid and nucleotide metabolism
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2013-11-08 — Biochemistry 08: the citric acid cycle and the electron transport chain
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2013-11-06 — Plotting antiprion compounds in the chemical space of drugs and libraries
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2013-10-28 — The evolution of cell-free prion conversion assays
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2013-10-26 — Biochemistry 07: glucose metabolism
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2013-10-26 — Highlights of ASHG2013
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2013-10-18 — Biochemistry 06: membranes, signaling and metabolism
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2013-10-17 — 2-aminothiazoles: a tale of drug resistance and strain specificity
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2013-10-17 — How prion protein was first purified
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2013-10-13 — Biochemistry 05: carbohydrates, glycoproteins and lipids
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2013-10-11 — Biochemistry 04: proteins and nucleic acids
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2013-10-11 — PERK inhibitors to save mice from prion disease?
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2013-10-04 — Properties of CNS drugs vs. all FDA-approved drugs
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2013-10-04 — List of FDA-approved drugs and CNS drugs with SMILES
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2013-09-25 — How to explain the discrepancy in PrPC half-life estimates in vivo
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2013-09-23 — A quick intro to chemical informatics in R
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2013-09-22 — Mouse models for studying human prion strains
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2013-09-22 — Interactive timepoint-delay plots using the Google Charts API
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2013-09-22 — Biochemistry 03: enzyme kinetics
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2013-09-22 — Biochemistry 02: protein structure and transport proteins
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2013-09-22 — Biochemistry 01: stereochemistry, thermodynamics, water and acid-base chemistry
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2013-09-17 — Genetic risk factors without heritability? The case of Parkinson's disease
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2013-09-16 — Revised budget for studies of anle138b in FFI and E200K mice
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2013-09-12 — Counts vs. FPKMs in RNA-seq
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2013-09-12 — Understanding chirality with keys and umbrellas
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2013-09-10 — Statistical power for bioluminescence studies
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2013-09-08 — Study design for therapeutic trials in FFI and E200K mice
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2013-09-04 — Methylenedioxyphenyl
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2013-09-01 — Objective measures of gene conservation applied to PrP
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2013-09-01 — pi: PrP's hypothetical backup protein
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2013-08-26 — Allele-specific RNA-seq pipeline using Gsnap and GATK
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2013-08-23 — Gene expression analysis QC pipeline in R
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2013-08-19 — Why we want to test anle138b in GSS mice
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2013-08-16 — Is Protein X the basis of dominant negative effects in prion disease?
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2013-08-15 — Allelic origin of PrPSc in heterozygotes
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2013-08-10 — Do we need PrPL to explain the neurotoxicity of prions?
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2013-08-01 — How compound incubation time affects power in anti-prion drug discovery screens
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2013-07-31 — MRC Prion Unit discusses possible clinical trial of PRN100 antibody
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2013-07-30 — Comparison of high-throughput screening approaches used for anti-prion small molecule discovery
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2013-07-29 — Introduction to conformation-dependent immunoassay
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2013-07-25 — The role of the proteasome in PrP degradation and prion disease
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2013-07-11 — Tissue-specific gene expression data based on Human BodyMap 2.0
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2013-07-11 — Prion protein degradation in lysosomes and the effect of autophagy-activating drugs
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2013-07-11 — Basics of protein degradation
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2013-07-04 — How to convert SAM to FASTQ with Unix command line tools
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2013-06-29 — Proteolytic shedding of prion protein
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2013-06-29 — Expanded multiple alignments of PrP
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2013-06-26 — Proteolysis of prion protein in the central region: alpha and beta cleavage
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2013-06-24 — The complicated relationship between copper, PrP and prion disease
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2013-06-19 — How censoring by life expectancy affects age of onset distributions
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2013-06-18 — How to do a GWAS for heterozygote advantage
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2013-06-14 — Histone marks at 5' vs. 3' ends of genes: a gentle slope or sudden dropoff?
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2013-06-11 — Timepoint-delay plots for comparing prion therapeutics tested in vivo
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2013-06-08 — A simple mathematical example of the glycoform "selection model"
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2013-06-08 — Facts about prion kinetics
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2013-06-08 — A "magic threshold" of PrP knockdown to reverse prion disease?
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2013-06-08 — A tour of the Zon lab and our introduction to zebrafish
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2013-06-01 — PrPC downregulation in prion infection
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2013-06-01 — GPM6A: an early biomarker of prion infection?
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2013-06-01 — 2-aminothiazoles: exciting progress and lessons for the field
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2013-06-01 — Updates on clinical trials of doxycycline for CJD at Prion2013
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2013-05-24 — A comparison of statin studies in scrapie-infected mice
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2013-05-18 — Updates on gene therapy for prion diseases
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2013-05-15 — Regulation of prion protein transcription
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2013-05-05 — Prion protein N-linked glycosylation: review and assessment of therapeutic potential
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2013-05-05 — Current status of efforts to delay genetic prion disease in humans
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2013-05-02 — Review of prion protein and amyloid beta interactions
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2013-05-02 — R equivalent of SQL coalesce
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2013-05-01 — Cell Biology 12: Stem Cells and Cancers
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2013-04-30 — Slope or correlation, not variance explained, allow estimation of heritability
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2013-04-28 — Cell Biology 11: Apoptosis & Necrosis
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2013-04-26 — Translating timepoints from mouse trials into human clinical trials
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2013-04-26 — anle138b: the new most promising experimental compound for treating prion diseases
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2013-04-20 — Blood lipids and prion diseases
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2013-04-20 — Cell Biology 10: Regulation of Transcription Through Signal Transduction
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2013-04-16 — Cell Biology 09: Signal Transduction
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2013-04-11 — Four quick proteomics analyses using PostgreSQL and R
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2013-04-08 — Half life of PrP and its mRNA
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2013-04-08 — The case for depleting PrP as a therapeutic strategy against prion diseases
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2013-04-08 — Review of drugs used in humans with prion disease
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2013-04-08 — Passive immunization against PrP
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2013-04-06 — Cell Biology 08: Cell Cycle Regulation and Checkpoints
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2013-04-04 — Tacrolimus, astemizole and a new screening approach for drugs that reduce PrP
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2013-04-03 — Association of repeat length polymorphisms with complex traits and common diseases
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2013-03-31 — PRNP deletions in 1000 Genomes are not real
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2013-03-30 — Cell Biology 07: Microtubules and Cell Division
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2013-03-20 — Can humans live without PrP?
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2013-03-19 — Automatically creating pivot table column names in PostgreSQL
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2013-03-17 — Polyene antifungal drugs for prion disease
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2013-03-15 — Mapping proteomics data to UniProt, RefSeq and gene symbols
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2013-03-14 — Fatal familial insomnia and the boy girl paradox
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2013-03-12 — Why we recommend 23andMe to everyone we know
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2013-03-10 — Cell Biology 06: The Cytoskeleton Part II: Tubulin
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2013-03-06 — 23andMe's coverage of rare prion diseases
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2013-03-05 — Heritability and genetic modifiers in Mendelian diseases
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2013-03-03 — Prospects for gene therapy of prion diseases
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2013-03-02 — Cell Biology 05: The Cytoskeleton Part I: Actin
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2013-02-28 — Help us win $10,000 for prion disease research
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2013-02-24 — Cell Biology 04: The Secretory Pathway
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2013-02-17 — Environmental modifiers for Huntington's age of onset?
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2013-02-17 — Cell Biology 03: Targeting proteins to organelles
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2013-02-12 — Finding all the polyQ genes in the human genome
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2013-02-10 — Cell Biology 02: The Plasma Membrane
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2013-02-05 — Fatal familial insomnia as a sleep disorder
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2013-02-04 — How to calculate heritability
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2013-02-01 — The decoy genome
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2013-01-31 — Mitochondrial heteroplasmy
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2013-01-30 — Center for Human Genetic Research 2013 Retreat
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2013-01-29 — Sampling a matching distribution for bootstrapping
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2013-01-27 — PrP / amyloid beta interactions and the prion disease / Alzheimer's connection
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2013-01-25 — Aligning unmapped reads to viral genomes
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2013-01-24 — How synonymous are synonymous SNPs?
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2013-01-23 — Huntington's Disease phenotypes in cell culture
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2013-01-21 — Advances in cell reprogramming
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2013-01-19 — TALENs and ZFNs
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2013-01-09 — Testing for repeat length association with phenotype using lobSTR
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2013-01-08 — Calling repeat length polymorphisms with lobSTR
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2012-12-31 — Electroconvulsive therapy, oxidative stress and prion disease
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2012-12-28 — Tips for dealing with NHGRI GWAS catalog data
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2012-12-27 — Biosafety levels for dealing with prions
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2012-12-27 — How to identify a disease-associated repeat expansion
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2012-12-19 — Forward and reverse reads in paired-end sequencing
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2012-12-17 — Chlorpromazine: another prion therapeutic of yesteryear
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2012-12-14 — Resources for systems biology in prion disease
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2012-12-14 — UAB day 4: analytical approaches
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2012-12-13 — The rise and fall of pentosan polysulfate in prion disease
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2012-12-13 — UAB day 3: models and tools
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2012-12-12 — UAB day 2: analysis, expression and epigenomics
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2012-12-11 — How PCR duplicates arise in next-generation sequencing
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2012-12-11 — UAB day 1: intro to sequencing
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2012-12-10 — Huntington's disease reading list
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2012-12-06 — Indometacin and the anti-inflammatory approach
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2012-12-05 — Power for GWAS and extreme phenotype studies
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2012-12-03 — Introduction to fatal familial insomnia
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2012-12-03 — Log-rank test power depends on variance
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2012-12-01 — Memantine
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2012-12-01 — Adverse effects of ibuprofen
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2012-11-30 — Power analysis for mouse studies using the t test vs. log-rank test
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2012-11-29 — PET with fluorodeoxyglucose as pre-symptomatic FFI diagnostic
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2012-11-29 — Student's t test vs. log-rank test for mouse studies
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2012-11-29 — Dapsone
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2012-11-28 — Background on heritability in Huntington's Disease age of onset
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2012-11-28 — The role of oxidation and Coenzyme Q in prion disease
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2012-11-26 — Advances in imaging of prion disease progression in mice and humans
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2012-11-26 — More about minocycline
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2012-11-25 — Promising molecules from high-throughput screening in the Groschup lab
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2012-11-25 — Resveratrol
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2012-11-24 — Porphyrin and phthalocyanine compounds
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2012-11-24 — Curcumin as prion therapeutic
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2012-11-24 — An introduction to high-throughput screening and its relevance to prion therapeutics
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2012-11-18 — Anti-PrP vaccines
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2012-11-16 — An introduction to Walker Jackson's fatal familial insomnia knock-in mice
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2012-11-16 — Can a human PRNP disease gene be knocked into mice?
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2012-11-14 — Multiple alignment of mammalian PrP amino acid sequences
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2012-11-13 — The difference between knock-in and transgenic mice
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2012-11-12 — annovar with GRCh37
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2012-11-11 — We're back
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2012-10-25 — Population Substructure, Part II
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2012-10-23 — Scutellaria lateriflora
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2012-10-23 — Fluphenazine, trimipramine and two styryl compounds
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2012-10-23 — Quinacrine
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2012-10-23 — Check out PrionAlliance.org
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2012-10-17 — Descriptive statistics and quality control on variants
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2012-10-16 — Imaging of amyloid plaques
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2012-10-15 — How (and why) to create population covariates using 1000 Genomes data
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2012-10-06 — Screen reveals antiprion compounds that act indirectly
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2012-10-06 — VPSPr: another strain of sporadic prion disease
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2012-09-28 — Statins as prion therapeutics
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2012-09-28 — Exosome miRNA signatures offer a possible prion diagnostic tool
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2012-09-25 — cpd-B as a prion therapeutic
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2012-09-25 — Implementation of RVT1 and RVT2 in R and SQL
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2012-09-19 — Exome sequencing pipeline using GATK
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2012-09-14 — The history of tetracyclines as treatments for prion disease
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2012-09-13 — Rapamycin delays disease onset in GSS mice
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2012-09-07 — An alternative exome sequencing pipeline using bowtie2 and samtools
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2012-09-07 — Issues with the conventional BWA-Picard-GATK exome sequencing pipeline
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2012-09-07 — Improvements in GATK 2.x
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2012-08-27 — FastQC for large numbers of samples
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2012-08-17 — SNP databases
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2012-08-17 — Exome sequencing reveals disease modifiers for cystic fibrosis
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2012-08-15 — QQ plots with matplotlib
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2012-08-13 — Biological and statistical considerations in exome analysis
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2012-08-13 — Getting started with analyzing sequence data
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2012-08-06 — Genome-wide association studies
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2012-08-03 — How Tafamidis was born
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2012-08-02 — Exome sequencing and analysis
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2012-08-02 — Huntington's becomes the huntingted
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2012-07-04 — Adiga on Bright Field Microscopy
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2012-07-01 — Visualizing staining variation using matplotlib
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2012-06-28 — New expression pattern data access from the Allen Institute
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2012-06-24 — Pentosan Polysulfate
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2012-06-24 — House prescribes Amphotericin
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2012-06-11 — The magic of blur and contrast
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2012-06-07 — Stem cell assays by the numbers
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2012-06-06 — Literature review: image segmentation on H&E-stained tissue samples
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2012-05-16 — Endoplasmic reticulum and the Golgi apparatus
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2012-05-13 — Color transformations for segmenting complex images
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2012-04-26 — Luminescent conjugated polymers
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2012-04-22 — Using the nasal-CNS connection to bypass the BBB
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2012-04-20 — Circadian rhythm regulators
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2012-04-16 — secondary oligomer as toxic species
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2012-04-13 — Diagnostic clinical study ongoing at UCSF
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2012-04-13 — Trimipramine and Fluphenazine
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2012-04-13 — CellProfiler in command line mode
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2012-04-13 — Convolutional Networks continued
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2012-03-31 — More on Convolutional Networks and Machine Learning
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2012-03-31 — Making sense of the Allen Institute mouse brain images
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2012-03-31 — iPS cells and neurodifferentiation
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2012-03-27 — Turaga, Murray 2010 - Convolutional Networks Can Learn to Generate Affinity Graphs for Image Segmentation
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2012-03-25 — Mouse brain images from the Allen Institute for Brain Science
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2012-03-24 — Jain 2010 - Machines that learn to segment images: a crucial technology for connectomics
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2012-03-24 — Jones 2009 - Scoring diverse cellular morphologies in image-based screens with iterative feedback and machine learning
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2012-03-24 — Kamentsky 2011 - Improved structure, function, and compatibility for CellProfiler: modular high-throughput image analysis software
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2012-03-24 — Histology, high-throughput screening and prion therapeutics
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2012-03-19 — Disulfide Bonds
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2012-03-10 — Prion workshop day 3
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2012-03-10 — Prion workshop day 2
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2012-03-10 — Prion workshop day 1
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2012-02-29 — Shape shifting: protein statistical physics as a linear programming problem
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2012-02-29 — The origin of Walker Jackson's FFI knock-in mice
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2012-02-28 — Lindquist lab follows up on yeast prion epigenetics
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2012-02-24 — Chaperonin nano-cages
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2012-02-24 — Heat shock protein review article
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2012-02-24 — Background on chaperones
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2012-02-21 — The state of gene therapy for HIV
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2012-02-19 — Coming soon in DNA sequencing technology
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2012-02-18 — Review article on why PrP exists
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2012-02-18 — Structure of FFI prion protein
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2012-02-17 — Bone marrow transplants and neurodegeneration
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2012-02-17 — More good reasons to eat turmeric
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2012-02-17 — Nanobiotechnology and DNA origami
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2012-02-15 — Autophagy and neuroprotection
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2012-02-14 — A quick tour of the brain
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2012-02-10 — Cancer Drug 'Rapidly Clears' Beta-Amyloid Plaques in Mice
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2012-02-07 — Science Night 2012.02.06
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2012-02-07 — Kuru and the G127V Polymorphism
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2012-02-07 — Finding the PRNP Gene Sequence
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2012-02-05 — I found this article which may be of...
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2012-02-03 — History of FFI by the New York Times
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2012-02-02 — Alzheimer's spreads through infectious tau proteins
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2012-02-02 — Heat shock transcription factors and protein chaperones
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2012-01-22 — Prion lectures by Susan Lindquist
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2012-01-18 — Clinical trial for doxycycline in FFI carriers will run from 2011-2022
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2012-01-18 — Materials from the annual CJD foundation family conference
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2012-01-18 — Science night notes 2012.01.16
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2012-01-18 — Allele-specific gene silencing using siRNA
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2012-01-17 — A helpful review from 2003 by Detlev Risener...
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2012-01-11 — Orphan drugs
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2012-01-11 — Spread of PrP(Sc) in vCJD -- follicular dendritic cells
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2012-01-11 — Cholesterol and lipids
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2012-01-10 — Oxidative stress and metals
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2012-01-10 — Prion replication vs. neurotoxicity
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2012-01-10 — Antisense therapy
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2012-01-10 — Crossing the blood-brain barrier
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2012-01-09 — Bruce's notes for phone call 2011.12.24
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2012-01-08 — Labs and resources
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2012-01-08 — Other potentially therapeutic drugs
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2012-01-08 — Native function of PrP(c)
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2012-01-08 — Bioinformatics
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2012-01-08 — Link to Alzheimer's
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2012-01-08 — Beta amyloid and melatonin
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2012-01-08 — Genomics
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2012-01-08 — Autophagy
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2012-01-08 — Tetracyclines
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2012-01-08 — Regenerative medicine/ stem cell therapy
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2012-01-08 — Prion protein folding
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2012-01-08 — Glossary Part 3
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2012-01-08 — Epigenetics
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2012-01-08 — Gene therapy
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2012-01-08 — Chemical chaperones
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2012-01-08 — Immunotherapy treatment
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2012-01-08 — Glossary Part 2
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2012-01-08 — Agrypnia excitata
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2012-01-08 — Nutrition
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2012-01-08 — Glossary Part 1
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2012-01-06 — The gene sequence for FFI